{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T04:18:47Z","timestamp":1747196327625,"version":"3.40.5"},"reference-count":23,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2022,12,30]],"date-time":"2022-12-30T00:00:00Z","timestamp":1672358400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"crossref","award":["21H04856"],"award-info":[{"award-number":["21H04856"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>COVID-19 vaccination for general population started on April 12, 2021, in Osaka, Japan. We investigated public attitudes toward vaccination and associated factors of vaccine hesitancy during the third state of emergency.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>An internet-based, self-reported, cross-sectional survey was conducted in June 2021, using the smartphone health app for residents of Osaka aged \u226518 years. Respondents were asked about their attitudes toward COVID-19 vaccine. Responses \u201cDon\u2019t want to receive vaccines\u201d or \u201cDon\u2019t know\u201d were defined as vaccine hesitancy (vs. \u201cReceived [1<jats:sup>st<\/jats:sup> dose]\u201d, \u201cReceived [2<jats:sup>nd<\/jats:sup> dose]\u201d, or \u201cWant to receive vaccines\u201d). Multivariable Poisson regression analysis was conducted to examine the associations between hesitancy and population characteristics.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>23,214 individuals (8,482 men &amp; 14,732 women) were included in the analysis. Proportions that answered \u201cReceived (1<jats:sup>st<\/jats:sup> dose)\u201d, \u201cReceived (2<jats:sup>nd<\/jats:sup> dose)\u201d, \u201cWant to receive vaccines\u201d, \u201cDon\u2019t want to receive vaccines\u201d, \u201cDon\u2019t know\u201d, and \u201cDon\u2019t want to answer\u201d were 14.6%, 3.8%, 70.6%, 4.3%, 6.1%, and 0.5% among men; and 11.3%, 6.0%, 64.9%, 6.2%, 11.0%, and 0.6% among women. Factors associated with vaccine hesitancy included being a woman (aPR = 1.33; 95%CI = 1.23\u20131.44), age 18\u201339 (aPR = 7.00; 95%CI = 6.01\u20138.17) and 40\u201364 years (aPR = 4.25; 95%CI = 3.71\u20134.88 vs. 65+ years), living alone (aPR = 1.19; 95%CI = 1.08\u20131.30 vs. living with 3+ members), non-full-time employment and unemployment (aPRs ranged 1.12 to 1.49 vs. full-time employment), cardiovascular diseases\/hypertension (aPR = 0.72; 95%CI = 0.65\u20130.81), and pregnancy (women of reproductive age only) (aPR = 1.35; 95%CI = 1.03\u20131.76).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusions<\/jats:title>\n<jats:p>Most respondents expressed favorable attitudes toward COVID-19 vaccination while hesitancy was disproportionately high in certain populations. Efforts are needed to ensure accessible vaccine information resources and healthcare services.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0279481","type":"journal-article","created":{"date-parts":[[2022,12,30]],"date-time":"2022-12-30T18:48:28Z","timestamp":1672426108000},"page":"e0279481","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":1,"title":["Attitudes toward COVID-19 vaccination during the state of emergency in Osaka, Japan"],"prefix":"10.1371","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6263-4952","authenticated-orcid":true,"given":"Satomi","family":"Odani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shihoko","family":"Koyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuichi","family":"Katsumi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isao","family":"Miyashiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2022,12,30]]},"reference":[{"key":"pone.0279481.ref001","unstructured":"World Health Organization. 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