{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:19:38Z","timestamp":1791307178020,"version":"4.3.1"},"reference-count":55,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2022,12,28]],"date-time":"2022-12-28T00:00:00Z","timestamp":1672185600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008005","name":"Yonsei University College of Medicine","doi-asserted-by":"publisher","award":["6-2014-0142"],"award-info":[{"award-number":["6-2014-0142"]}],"id":[{"id":"10.13039\/501100008005","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>We aimed to define the shared and unshared functional neurobiological underpinnings of binge eating disorder (BED) and bulimia nervosa (BN). These disorders both involve loss of control over binge eating, but differ based on purging behavior and body image distortion. BED and BN have also been found to show differences in brain activation patterns in reward sensitivity. We enrolled 13 and 12 drug-naive and medication-free women with BED and BN, respectively, and 22 age- and sex-matched healthy controls. We performed an orbitofrontal cortex (OFC)-seeded resting-state whole brain functional connectivity (FC) analysis among the groups. In this study, BED patients exhibited significantly higher impulsivity than controls, whereas the difference in impulsivity between BN and controls was not significant. Participants with BED and BN showed weaker FC between the left lateral OFC and the right precuneus than controls. In the BED only group, the FC strength between these regions was negatively correlated with self-reported impulsivity. In both BED and BN, FC between the left lateral OFC and the right dorsolateral prefrontal cortex was weaker than that in controls. In BED, FC between the left medial OFC and the right cerebellar lobule IV was stronger than that of other groups. Our current results suggest similarities and differences between BED and BN in OFC-seeded FC with respect to reward processing. In particular, FC of the OFC in BED patients showed a significant correlation with their high impulsivity, which may reflect a decline in executive control over binge eating.<\/jats:p>","DOI":"10.1371\/journal.pone.0279577","type":"journal-article","created":{"date-parts":[[2022,12,28]],"date-time":"2022-12-28T18:25:37Z","timestamp":1672251937000},"page":"e0279577","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":16,"title":["Orbitofrontal cortex functional connectivity changes in patients with binge eating disorder and bulimia nervosa"],"prefix":"10.1371","volume":"17","author":[{"given":"Jaeun","family":"Ahn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DeokJong","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung Eun","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0578-2510","authenticated-orcid":true,"given":"Young-Chul","family":"Jung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2022,12,28]]},"reference":[{"key":"pone.0279577.ref001","first-page":"70","volume-title":"DSM 5.","author":"Association AP, Association AP","year":"2013"},{"key":"pone.0279577.ref002","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/s41380-021-01161-7","article-title":"Age at onset of mental disorders worldwide: large-scale meta-analysis of 192 epidemiological studies","volume":"27","author":"M Solmi","year":"2022","journal-title":"Molecular psychiatry"},{"key":"pone.0279577.ref003","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/S0191-8869(01)00071-X","article-title":"Impulsive and compulsive traits in eating disordered patients compared with controls","volume":"32","author":"L Claes","year":"2002","journal-title":"Pers Individ Dif"},{"key":"pone.0279577.ref004","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1002\/eat.10099","article-title":"Temperament and character profile of eating disorders: a controlled study with the Temperament and Character Inventory","volume":"32","author":"S Fassino","year":"2002","journal-title":"Int J Eat Disord"},{"key":"pone.0279577.ref005","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1002\/erv.532","article-title":"Cognitive and behavioural characteristics are associated with personality dimensions in patients with eating disorders.","volume":"11","author":"M Vervaet","year":"2003","journal-title":"European Eating Disorders Review: The Professional Journal of the Eating Disorders Association"},{"key":"pone.0279577.ref006","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1037\/a0039268","article-title":"A risk and maintenance model for bulimia nervosa: From impulsive action to compulsive behavior","volume":"122","author":"CM Pearson","year":"2015","journal-title":"Psychological Review"},{"key":"pone.0279577.ref007","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.3390\/nu9111170","article-title":"Food-related impulsivity in obesity and binge eating disorder\u2014a systematic update of the evidence","volume":"9","author":"KE Giel","year":"2017","journal-title":"Nutrients"},{"key":"pone.0279577.ref008","doi-asserted-by":"crossref","first-page":"e76542","DOI":"10.1371\/journal.pone.0076542","article-title":"Impulsivity in binge eating disorder: food cues elicit increased reward responses and disinhibition","volume":"8","author":"K Schag","year":"2013","journal-title":"PloS one"},{"key":"pone.0279577.ref009","volume-title":"Cognitive behavior therapy and eating disorders:","author":"CG Fairburn","year":"2008"},{"key":"pone.0279577.ref010","first-page":"9","article-title":"Volume and connectivity differences in brain networks associated with cognitive constructs of binge eating","author":"B Hartogsveld","year":"2022","journal-title":"Eneuro"},{"key":"pone.0279577.ref011","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1093\/scan\/nsw049","article-title":"Neural signature of food reward processing in bulimic-type eating disorders","volume":"11","author":"JJ Simon","year":"2016","journal-title":"Social cognitive and affective neuroscience"},{"key":"pone.0279577.ref012","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.biopsych.2008.09.028","article-title":"Binge-eating disorder: reward sensitivity and brain activation to images of food","volume":"65","author":"A Schienle","year":"2009","journal-title":"Biological psychiatry"},{"key":"pone.0279577.ref013","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1111\/ejn.13507","article-title":"Interhemispheric functional connectivity in anorexia and bulimia nervosa","volume":"45","author":"A Canna","year":"2017","journal-title":"European Journal of Neuroscience"},{"key":"pone.0279577.ref014","doi-asserted-by":"crossref","first-page":"e01207","DOI":"10.1002\/brb3.1207","article-title":"Altered functional connectivity in binge eating disorder and bulimia nervosa: A resting\u2010state fMRI study","volume":"9","author":"MA Stopyra","year":"2019","journal-title":"Brain and behavior"},{"key":"pone.0279577.ref015","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1038\/nrn3292","article-title":"Multisensory brain mechanisms of bodily self-consciousness","volume":"13","author":"O. Blanke","year":"2012","journal-title":"Nature Reviews Neuroscience"},{"key":"pone.0279577.ref016","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1002\/eat.23212","article-title":"Characterizing impulsivity and resting\u2010state functional connectivity in normal\u2010weight binge eaters","volume":"53","author":"R Oliva","year":"2020","journal-title":"International Journal of Eating Disorders"},{"key":"pone.0279577.ref017","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.eurpsy.2018.08.005","article-title":"Neuronal variability of Resting State activity in Eating Disorders: increase and decoupling in Ventral Attention Network and relation with clinical symptoms","volume":"55","author":"AV Spalatro","year":"2019","journal-title":"European Psychiatry"},{"key":"pone.0279577.ref018","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1038\/nn.2921","article-title":"Medial prefrontal cortex as an action-outcome predictor","volume":"14","author":"WH Alexander","year":"2011","journal-title":"Nature neuroscience"},{"key":"pone.0279577.ref019","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/j.1749-6632.2011.06277.x","article-title":"Contrasting reward signals in the orbitofrontal cortex and anterior cingulate cortex","volume":"1239","author":"JD Wallis","year":"2011","journal-title":"Annals of the New York Academy of Sciences"},{"key":"pone.0279577.ref020","doi-asserted-by":"crossref","first-page":"3001","DOI":"10.1007\/s00429-019-01945-2","article-title":"The cingulate cortex and limbic systems for emotion, action, and memory","volume":"224","author":"ET Rolls","year":"2019","journal-title":"Brain Structure and Function"},{"key":"pone.0279577.ref021","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1038\/nrn1747","article-title":"The human orbitofrontal cortex: linking reward to hedonic experience","volume":"6","author":"ML Kringelbach","year":"2005","journal-title":"Nature reviews neuroscience"},{"key":"pone.0279577.ref022","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1093\/cercor\/bhm044","article-title":"Stop-signal reaction-time task performance: role of prefrontal cortex and subthalamic nucleus","volume":"18","author":"DM Eagle","year":"2008","journal-title":"Cerebral cortex"},{"key":"pone.0279577.ref023","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.neuron.2006.06.027","article-title":"Encoding of time-discounted rewards in orbitofrontal cortex is independent of value representation","volume":"51","author":"MR Roesch","year":"2006","journal-title":"Neuron"},{"key":"pone.0279577.ref024","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1503\/jpn.160183","article-title":"Altered intrinsic functional brain architecture in female patients with bulimia nervosa. Journal of psychiatry & neuroscience","volume":"42","author":"L Wang","year":"2017","journal-title":"JPN"},{"key":"pone.0279577.ref025","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.pscychresns.2013.11.004","article-title":"Resting-state synchrony between anterior cingulate cortex and precuneus relates to body shape concern in anorexia nervosa and bulimia nervosa","volume":"221","author":"S Lee","year":"2014","journal-title":"Psychiatry Research: Neuroimaging"},{"key":"pone.0279577.ref026","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.neulet.2012.05.075","article-title":"Functional and effective connectivity of anterior insula in anorexia nervosa and bulimia nervosa","volume":"521","author":"KR Kim","year":"2012","journal-title":"Neuroscience letters"},{"key":"pone.0279577.ref027","doi-asserted-by":"crossref","first-page":"6398","DOI":"10.1523\/JNEUROSCI.6620-10.2011","article-title":"Dissociable effects of lesions to orbitofrontal cortex subregions on impulsive choice in the rat","volume":"31","author":"AC Mar","year":"2011","journal-title":"Journal of Neuroscience"},{"key":"pone.0279577.ref028","doi-asserted-by":"crossref","first-page":"4600","DOI":"10.1523\/JNEUROSCI.4253-15.2016","article-title":"The medial orbitofrontal cortex regulates sensitivity to outcome value","volume":"36","author":"SL Gourley","year":"2016","journal-title":"Journal of Neuroscience"},{"key":"pone.0279577.ref029","doi-asserted-by":"crossref","first-page":"25","DOI":"10.3389\/fnsys.2017.00025","article-title":"Cortico-striatal-thalamic loop circuits of the orbitofrontal cortex: promising therapeutic targets in psychiatric illness","volume":"11","author":"P Fettes","year":"2017","journal-title":"Frontiers in systems neuroscience"},{"key":"pone.0279577.ref030","first-page":"50","article-title":"Validity of Korean version of the mini-international neuropsychiatric interview","volume":"2","author":"S-W Yoo","year":"2006","journal-title":"Anxiety and mood"},{"key":"pone.0279577.ref031","article-title":"A standardization study of the Eating Attitudes Test-26: Korean version (KEAT-26) I: Reliability and factor analysis","author":"M Rhee","year":"1988","journal-title":"Korean J. Psychosom. Med."},{"key":"pone.0279577.ref032","first-page":"1","article-title":"Structured clinical interview for the DSM (SCID)","author":"MB First","year":"2014","journal-title":"The encyclopedia of clinical psychology"},{"key":"pone.0279577.ref033","doi-asserted-by":"crossref","first-page":"345","DOI":"10.17315\/kjhp.2010.15.2.011","article-title":"Reliability and factor structure of the Korean version of Eating Disorder Examination Questionnaire","volume":"15","author":"S Lim","year":"2010","journal-title":"Korean Journal of Health Psychology"},{"key":"pone.0279577.ref034","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0306-4603(82)90024-7","article-title":"The assessment of binge eating severity among obese persons","volume":"7","author":"J Gormally","year":"1982","journal-title":"Addict Behav"},{"key":"pone.0279577.ref035","first-page":"487","article-title":"A standardization study of Beck Depression Inventory in Korea","volume":"25","author":"H. Hahn","year":"1982","journal-title":"J Korean Neuropsychiatr Asso"},{"key":"pone.0279577.ref036","first-page":"185","article-title":"A clinical study on the Korean version of Beck Anxiety Inventory: comparative study of patient and non-patient","volume":"16","author":"S Yook","year":"1997","journal-title":"Korean J Clin Psychol"},{"key":"pone.0279577.ref037","volume-title":"Guidance of impulsivity test","author":"H. Lee","year":"1992"},{"key":"pone.0279577.ref038","volume-title":"The questionnaire on eating and weight patterns-revised (QEWP-R)","author":"R Spitzer","year":"1993"},{"key":"pone.0279577.ref039","volume-title":"Korean Wechsler Adult Intelligence Scale:","author":"S Hwang","year":"2012"},{"key":"pone.0279577.ref040","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.neuroimage.2017.12.073","article-title":"An evaluation of the efficacy, reliability, and sensitivity of motion correction strategies for resting-state functional MRI","volume":"171","author":"L Parkes","year":"2018","journal-title":"Neuroimage"},{"key":"pone.0279577.ref041","doi-asserted-by":"crossref","first-page":"6240","DOI":"10.1523\/JNEUROSCI.0257-12.2012","article-title":"Connectivity-based parcellation of the human orbitofrontal cortex","volume":"32","author":"T Kahnt","year":"2012","journal-title":"J Neurosci"},{"key":"pone.0279577.ref042","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1159\/000329358","article-title":"Different moderators of cognitive-behavioral therapy on subjective and objective binge eating in bulimia nervosa and binge eating disorder: a three-year follow-up study","volume":"81","author":"G Castellini","year":"2012","journal-title":"Psychotherapy and psychosomatics"},{"key":"pone.0279577.ref043","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1002\/eat.1021","article-title":"Importance of size in defining binge eating episodes in bulimia nervosa","volume":"29","author":"PK Keel","year":"2001","journal-title":"International Journal of Eating Disorders"},{"key":"pone.0279577.ref044","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.neuroimage.2013.04.011","article-title":"Subregions of the human superior frontal gyrus and their connections","volume":"78","author":"W Li","year":"2013","journal-title":"Neuroimage"},{"key":"pone.0279577.ref045","doi-asserted-by":"crossref","first-page":"12688","DOI":"10.1523\/JNEUROSCI.1175-16.2016","article-title":"The Right Superior Frontal Gyrus and Individual Variation in Proactive Control of Impulsive Response","volume":"36","author":"S Hu","year":"2016","journal-title":"The Journal of Neuroscience"},{"key":"pone.0279577.ref046","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.paid.2019.03.003","article-title":"Does impulsivity converge distinctively with inhibitory control? Disentangling the cold and hot aspects of inhibitory control","volume":"145","author":"R Leshem","year":"2019","journal-title":"Personality and Individual Differences"},{"key":"pone.0279577.ref047","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.paid.2006.01.011","article-title":"Associations between laboratory measures of executive inhibitory control and self-reported impulsivity","volume":"41","author":"PG Enticott","year":"2006","journal-title":"Personality and Individual Differences"},{"key":"pone.0279577.ref048","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.ijpsycho.2020.11.014","article-title":"The neural basis underlying the relation between the action identification level and delay discounting: The medial and orbital frontal cortex functional connectivity with the precuneus","volume":"159","author":"R Zhang","year":"2021","journal-title":"International Journal of Psychophysiology"},{"key":"pone.0279577.ref049","first-page":"1","article-title":"Intrinsic functional connectivity of blue and red brains: neurobiological evidence of different stress resilience between political attitudes","volume":"10","author":"T Kim","year":"2020","journal-title":"Sci Rep"},{"key":"pone.0279577.ref050","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.eatbeh.2018.03.009","article-title":"The moderating role of resilience on the relationship between perceived stress and binge eating symptoms among young adult women","volume":"29","author":"IB Thurston","year":"2018","journal-title":"Eating behaviors"},{"key":"pone.0279577.ref051","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1007\/s11065-010-9142-x","article-title":"The role of the cerebellum in cognition and emotion: personal reflections since 1982 on the dysmetria of thought hypothesis, and its historical evolution from theory to therapy","volume":"20","author":"JD Schmahmann","year":"2010","journal-title":"Neuropsychology review"},{"key":"pone.0279577.ref052","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1007\/s12311-013-0471-1","article-title":"Intrinsic connectivity networks within cerebellum and beyond in eating disorders","volume":"12","author":"F Amianto","year":"2013","journal-title":"The Cerebellum"},{"key":"pone.0279577.ref053","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1038\/nrn3119","article-title":"Dysfunction of the prefrontal cortex in addiction: neuroimaging findings and clinical implications","volume":"12","author":"RZ Goldstein","year":"2011","journal-title":"Nature reviews neuroscience"},{"key":"pone.0279577.ref054","doi-asserted-by":"crossref","first-page":"8586","DOI":"10.1523\/JNEUROSCI.1868-09.2009","article-title":"Distinct cerebellar contributions to intrinsic connectivity networks","volume":"29","author":"C Habas","year":"2009","journal-title":"J Neurosci"},{"key":"pone.0279577.ref055","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/978-3-030-43562-2_1","article-title":"Epidemiology of binge eating","author":"MR Wick","year":"2020","journal-title":"Binge Eating"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0279577","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,28]],"date-time":"2022-12-28T18:26:22Z","timestamp":1672251982000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0279577"}},"subtitle":[],"editor":[{"given":"Vincenzo","family":"De Luca","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,12,28]]},"references-count":55,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2022,12,28]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0279577","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,28]]}}}