{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T12:13:03Z","timestamp":1781093583507,"version":"3.54.1"},"reference-count":25,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2022,12,22]],"date-time":"2022-12-22T00:00:00Z","timestamp":1671667200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002648","name":"Catholic University of Korea","doi-asserted-by":"publisher","award":["ZC20RISI0730"],"award-info":[{"award-number":["ZC20RISI0730"]}],"id":[{"id":"10.13039\/501100002648","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Research Found Government","award":["2021R1F1A1049557"],"award-info":[{"award-number":["2021R1F1A1049557"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Objective<\/jats:title>\n<jats:p>This study aimed to investigate the prevalence and extent of dental developmental complications in patients who have undergone pediatric hematopoietic stem cell transplantation (SCT) and identify the risk factors.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Materials and methods<\/jats:title>\n<jats:p>We retrospectively investigated the clinical data warehouse of the Catholic Medical Center information system for identifying patients who: 1) visited the Department of Pediatrics between 2009 and 2019, 2) underwent SCT under the age of 10, and 3) had panoramic radiographs. Thus 153 patients were included in this study. The prevalence and extent of tooth agenesis, microdontia, and root malformation were assessed using panoramic radiographs obtained after SCT, and the risk factors were analyzed using regression analysis.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>All 153 patients had at least one dental anomaly. When grouped according to the age at initial chemotherapy (\u2264 2.5; 2.6\u20135.0; 5.1\u20137.5; &gt; 7.5 years), the prevalence of agenesis showed statistically significant differences among the different age groups (P &lt; 0.001). The prevalence of agenesis was highest in the youngest age group. As the initial age at chemotherapy increased, the number of affected teeth per patient decreased for all three anomalies. The location of the affected tooth was also influenced by the age at initial chemotherapy. Regression analysis demonstrated that young age at initial chemotherapy was a risk-increasing factor for tooth agenesis and microdontia.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusions<\/jats:title>\n<jats:p>The age at initial chemotherapy may be a critical factor in determining the type, extent, and location of dental complications after SCT. These results suggest that careful dental follow-up and timely treatment are recommended for pediatric patients undergoing SCT.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0279579","type":"journal-article","created":{"date-parts":[[2022,12,22]],"date-time":"2022-12-22T18:40:59Z","timestamp":1671734459000},"page":"e0279579","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":5,"title":["Dental developmental complications in pediatric hematopoietic stem cell transplantation patients: A study using CMC clinical data warehouse"],"prefix":"10.1371","volume":"17","author":[{"given":"Jaehyun","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hee Jin","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ja Hyeong","family":"Ku","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoon-Ah","family":"Kook","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nack-Gyun","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1664-3137","authenticated-orcid":true,"given":"Yoonji","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2022,12,22]]},"reference":[{"key":"pone.0279579.ref001","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.ejca.2017.07.014","article-title":"Survival for patients with rare haematologic malignancies: Changes in the early 21st century","volume":"84","author":"D Pulte","year":"2017","journal-title":"Eur J Cancer"},{"key":"pone.0279579.ref002","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1542\/peds.2006-2826","article-title":"The late effects of childhood cancer therapy","volume":"119","author":"JD Dickerman","year":"2007","journal-title":"Pediatrics"},{"key":"pone.0279579.ref003","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.oraloncology.2018.06.001","article-title":"Adverse effects of chemotherapy on the teeth and surrounding tissues of children with cancer: A systematic review with meta-analysis","volume":"83","author":"DM Busenhart","year":"2018","journal-title":"Oral Oncol"},{"key":"pone.0279579.ref004","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/0030-4220(88)90189-2","article-title":"Disturbances in dental development after total body irradiation in bone marrow transplant recipients","volume":"65","author":"G Dahll\u00f6f","year":"1988","journal-title":"Oral Surgery, Oral Med Oral Pathol"},{"key":"pone.0279579.ref005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/cancers12061634","article-title":"Oral manifestations and complications in childhood acute myeloid leukemia","volume":"12","author":"F Cammarata\u2010Scalisi","year":"2020","journal-title":"Cancers (Basel)"},{"key":"pone.0279579.ref006","doi-asserted-by":"crossref","first-page":"926","DOI":"10.4143\/crt.2017.296","article-title":"Clinical risk factors influencing dental developmental disturbances in childhood cancer survivors","volume":"50","author":"CM Kang","year":"2018","journal-title":"Cancer Res Treat"},{"key":"pone.0279579.ref007","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1002\/cncr.20967","article-title":"Disturbed root development of permanent teeth after pediatric stem cell transplantation: Dental root development after SCT","volume":"103","author":"P H\u00f6ltt\u00e4","year":"2005","journal-title":"Cancer"},{"key":"pone.0279579.ref008","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/sj.bmt.1703330","article-title":"Long-term adverse effects on dentition in children with poor-risk neuroblastoma treated with high-dose chemotherapy and autologous stem cell transplantation with or without total body irradiation","volume":"29","author":"P H\u00f6ltt\u00e4","year":"2002","journal-title":"Bone Marrow Transplant"},{"key":"pone.0279579.ref009","first-page":"27","article-title":"Oral and dental alterations and growth disruption following chemotherapy in long-term survivors of childhood malignancies","author":"D \u00c7etiner","year":"2019","journal-title":"Support Care Cancer"},{"key":"pone.0279579.ref010","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1007\/s00520-015-2940-1","article-title":"Dental abnormalities after chemotherapy in long-term survivors of childhood acute lymphoblastic leukemia 7\u201340 years after diagnosis","volume":"24","author":"P Wilberg","year":"2016","journal-title":"Support Care Cancer"},{"key":"pone.0279579.ref011","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1093\/ejo\/19.2.151","article-title":"Long-term dental development in children after treatment for malignant disease","volume":"19","author":"M N\u00e4sman","year":"1997","journal-title":"Eur J Orthod"},{"key":"pone.0279579.ref012","doi-asserted-by":"crossref","first-page":"2219","DOI":"10.1002\/cncr.25704","article-title":"Association of cyclophosphamide use with dental developmental defects and salivary gland dysfunction in recipients of childhood antineoplastic therapy","volume":"117","author":"SGS Hsieh","year":"2011","journal-title":"Cancer"},{"key":"pone.0279579.ref013","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1038\/sj.bmt.1700993","article-title":"Long-term effects of bone marrow- transplantation on dental status in children with leukaemia","volume":"20","author":"C Uderzo","year":"1997","journal-title":"Bone Marrow Transplant"},{"key":"pone.0279579.ref014","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1067\/mod.2001.118102","article-title":"Orthodontic treatment in long-term survivors after pediatric bone marrow transplantation","volume":"120","author":"G Dahll\u00f6f","year":"2001","journal-title":"Am J Orthod Dentofac Orthop"},{"key":"pone.0279579.ref015","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1002\/cncr.20762","article-title":"Agenesis and microdontia of permanent teeth as late adverse effects after stem cell transplantation in young children","volume":"103","author":"P H\u00f6ltt\u00e4","year":"2005","journal-title":"Cancer"},{"key":"pone.0279579.ref016","doi-asserted-by":"crossref","first-page":"5817","DOI":"10.1002\/cncr.24670","article-title":"Impact of radiation and chemotherapy on risk of dental abnormalities: A report from the childhood cancer survivor study","volume":"115","author":"SC Kaste","year":"2009","journal-title":"Cancer"},{"key":"pone.0279579.ref017","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/j.1601-6343.2011.01533.x","article-title":"Disturbances in dental development and craniofacial growth in children treated with hematopoietic stem cell transplantation","volume":"15","author":"M Vesterbacka","year":"2012","journal-title":"Orthod Craniofacial Res"},{"key":"pone.0279579.ref018","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1111\/ecc.12038","article-title":"Risk factors to cause tooth formation anomalies in chemotherapy of paediatric cancers","volume":"22","author":"S Nishimura","year":"2013","journal-title":"Eur J Cancer Care (Engl)"},{"key":"pone.0279579.ref019","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1002\/pbc.22902","article-title":"Disturbed dental development of permanent teeth in children with solid tumors and lymphomas","volume":"58","author":"CE Cubukcu","year":"2012","journal-title":"Pediatr Blood Cancer"},{"key":"pone.0279579.ref020","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/j.0909-8836.2004.00094.x","article-title":"Long-term effects of chemotherapy on orodental structures in children with non-Hodgkin\u2019s lymphoma","volume":"112","author":"A O\u01e7uz","year":"2004","journal-title":"Eur J Oral Sci"},{"key":"pone.0279579.ref021","doi-asserted-by":"crossref","first-page":"375","DOI":"10.4067\/S0717-95022019000100375","article-title":"Proposal of anatomical terms for alterations in tooth size: \u201cMicrodontia and macrodontia","volume":"37","author":"S. P Agurto","year":"2019","journal-title":"Int J Morphol"},{"key":"pone.0279579.ref022","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/0003-9969(81)90023-6","article-title":"The effects of cyclophosphamide on eruption of the continuously growing mandibular incisor of the rat","volume":"26","author":"AK Adatia","year":"1981","journal-title":"Arch Oral Biol"},{"key":"pone.0279579.ref023","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1002\/ajpa.21258","article-title":"Brief communication: The London atlas of human tooth development and eruption","volume":"142","author":"SJ AlQahtani","year":"2010","journal-title":"Am J Phys Anthropol"},{"key":"pone.0279579.ref024","doi-asserted-by":"crossref","first-page":"324","DOI":"10.4041\/kjod21.280","article-title":"Common dental anomalies in Korean orthodontic patients: An update","volume":"52","author":"JH Ku","year":"2022","journal-title":"Korean J Orthod"},{"key":"pone.0279579.ref025","doi-asserted-by":"crossref","first-page":"2009","DOI":"10.1007\/s00520-014-2260-x","article-title":"Oral and dental late effects in survivors of childhood cancer: a Children\u2019s Oncology Group report","volume":"22","author":"KE Effinger","year":"2014","journal-title":"Support Care Cancer"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0279579","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,22]],"date-time":"2022-12-22T18:41:24Z","timestamp":1671734484000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0279579"}},"subtitle":[],"editor":[{"given":"Nazmul","family":"Haque","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,12,22]]},"references-count":25,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2022,12,22]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0279579","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,22]]}}}