{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T02:48:18Z","timestamp":1773456498723,"version":"3.50.1"},"reference-count":76,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2022,12,30]],"date-time":"2022-12-30T00:00:00Z","timestamp":1672358400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The National Science, Research and Innovation Fund (NSRF), Thailand for Khon Kaen University"},{"name":"Research Program, Research and Graduate studies, Khon Kaen University","award":["RP-65-3-001"],"award-info":[{"award-number":["RP-65-3-001"]}]},{"name":"Research Program, Research and Graduate studies, Khon Kaen University","award":["RP-65-3-001"],"award-info":[{"award-number":["RP-65-3-001"]}]},{"name":"Research Program, Research and Graduate studies, Khon Kaen University","award":["RP-65-3-001"],"award-info":[{"award-number":["RP-65-3-001"]}]},{"name":"Scholarship under the Post-Doctoral Training Program from Khon Kaen University, Thailand","award":["PD2565-02-03"],"award-info":[{"award-number":["PD2565-02-03"]}]},{"name":"Khon Kaen University Faculty of Medicine","award":["RG63301"],"award-info":[{"award-number":["RG63301"]}]},{"name":"Khon Kaen University Faculty of Medicine","award":["RG63301"],"award-info":[{"award-number":["RG63301"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>Human gastrointestinal helminthic infections have a direct and\/or indirect effect on the composition of the host gut microbial flora. Here, we investigated the effect of infection with a soil-transmitted intestinal nematode, <jats:italic>Strongyloides stercoralis<\/jats:italic>, on the gut microbiota of the human host. We also investigated whether composition of the microbiota in infected persons might vary across endemic regions. Fecal samples were obtained from volunteers from two areas endemic for strongyloidiasis, Khon Kaen Province in northeastern Thailand and Nakhon Si Thammarat Province in southern Thailand. Samples from Khon Kaen were from infected (SsNE) and uninfected (NegNE) individuals. Similarly, samples from the latter province were from infected (SsST) and uninfected (NegST) individuals. DNA sequences of the V3-V4 regions of the bacterial 16S rRNA gene were obtained from the fecal samples. No statistical difference in alpha diversity between groups in terms of richness or diversity were found. Statistical difference in beta diversity was observed only between NegNE and NegST. Some significant differences in species abundance were noted between geographical isolates. The SsNE group had a higher abundance of <jats:italic>Tetragenococcus holophilus<\/jats:italic> than did the SsST group, whereas <jats:italic>Bradyrhizobium<\/jats:italic> sp. was less abundant in the SsNE than the SsST group. For the uninfected groups, the NegNE had a higher abundance of <jats:italic>T<\/jats:italic>. <jats:italic>holophilus<\/jats:italic> than the NegST group. Our data showed that <jats:italic>S<\/jats:italic>. <jats:italic>stercoralis<\/jats:italic> infection leads to only minor alterations in the relative abundance of individual bacterial species in the human gut: no detectable effect was observed on community structure and diversity.<\/jats:p>","DOI":"10.1371\/journal.pone.0279766","type":"journal-article","created":{"date-parts":[[2022,12,30]],"date-time":"2022-12-30T18:55:21Z","timestamp":1672426521000},"page":"e0279766","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":1,"title":["Gut microbiota diversity in human strongyloidiasis differs little in two different regions in endemic areas of Thailand"],"prefix":"10.1371","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0281-2101","authenticated-orcid":true,"given":"Rutchanee","family":"Rodpai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oranuch","family":"Sanpool","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Penchom","family":"Janwan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5873-2392","authenticated-orcid":true,"given":"Patcharaporn","family":"Boonroumkaew","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lakkhana","family":"Sadaow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tongjit","family":"Thanchomnang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pewpan M.","family":"Intapan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6726-3759","authenticated-orcid":true,"given":"Wanchai","family":"Maleewong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2022,12,30]]},"reference":[{"key":"pone.0279766.ref001","first-page":"17","article-title":"Part 1: The human gut microbiome in health and disease","volume":"13","author":"MJ Bull","year":"2014","journal-title":"Integr Med (Encinitas)"},{"key":"pone.0279766.ref002","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1042\/BCJ20160510","article-title":"Introduction to the human gut microbiota","volume":"474","author":"E Thursby","year":"2017","journal-title":"Biochem"},{"key":"pone.0279766.ref003","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12328-017-0813-5","article-title":"Gut microbiota in the pathogenesis of inflammatory bowel disease","volume":"11","author":"A Nishida","year":"2018","journal-title":"Clin J Gastroenterol"},{"key":"pone.0279766.ref004","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1136\/gutjnl-2015-309333","article-title":"Dysbiotic gut microbiota causes transmissible Crohn\u2019s disease-like ileitis independent of failure in antimicrobial defence","volume":"65","author":"M Schaubeck","year":"2016","journal-title":"Gut"},{"key":"pone.0279766.ref005","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1111\/apt.16656","article-title":"Systematic review: the association between the gut microbiota and medical therapies in inflammatory bowel disease","volume":"55","author":"ST Radhakrishnan","year":"2022","journal-title":"Aliment Pharmacol Ther"},{"key":"pone.0279766.ref006","doi-asserted-by":"crossref","first-page":"f4610","DOI":"10.1136\/bmj.f4610","article-title":"Strongyloides stercoralis infection","volume":"347","author":"D Greaves","year":"2013","journal-title":"BMJ"},{"key":"pone.0279766.ref007","doi-asserted-by":"crossref","first-page":"e0009597","DOI":"10.1371\/journal.pntd.0009597","article-title":"Field evaluation of the gut microbiome composition of pre-school and school-aged children in Tha Song Yang, Thailand, following oral MDA for STH infections","volume":"15","author":"K Stracke","year":"2021","journal-title":"PLoS Negl Trop Dis"},{"key":"pone.0279766.ref008","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.ijpara.2012.10.015","article-title":"A role for IL-22 in the relationship between intestinal helminths, gut microbiota and mucosal immunity","volume":"43","author":"JM Leung","year":"2013","journal-title":"Int J Parasitol"},{"key":"pone.0279766.ref009","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1017\/S0031182014000699","article-title":"The microbiota and helminths: sharing the same niche in the human host","volume":"141","author":"L Glendinning","year":"2014","journal-title":"Parasitology"},{"key":"pone.0279766.ref010","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1038\/nrg3182","article-title":"The human microbiome: at the interface of health and disease","volume":"13","author":"I Cho","year":"2012","journal-title":"Nat Rev Genet"},{"key":"pone.0279766.ref011","doi-asserted-by":"crossref","first-page":"e76573","DOI":"10.1371\/journal.pone.0076573","article-title":"Patent human infections with the whipworm, Trichuris trichiura, are not associated with alterations in the faecal microbiota","volume":"8","author":"P Cooper","year":"2013","journal-title":"PLoS One"},{"key":"pone.0279766.ref012","doi-asserted-by":"crossref","first-page":"e0184719","DOI":"10.1371\/journal.pone.0184719","article-title":"Infections by human gastrointestinal helminths are associated with changes in faecal microbiota diversity and composition","volume":"12","author":"TP Jenkins","year":"2017","journal-title":"PLoS One"},{"key":"pone.0279766.ref013","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s13099-021-00406-8","article-title":"No distinction in the gut microbiota between diarrhea predominant-irritable bowel syndrome and healthy subjects: matched case-control study","volume":"13","author":"S Jandee","year":"2021","journal-title":"Thailand. Gut Pathog"},{"key":"pone.0279766.ref014","doi-asserted-by":"crossref","first-page":"E468","DOI":"10.3390\/pathogens9060468","article-title":"The global prevalence of Strongyloides stercoralis infection","volume":"9","author":"D Buonfrate","year":"2020","journal-title":"Pathogens"},{"key":"pone.0279766.ref015","unstructured":"World Health Organization. Soil-transmitted helminth infections. 2022 [cited 11 Jan 2022]. Available: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/soil-transmitted-helminth-infections"},{"key":"pone.0279766.ref016","first-page":"442","article-title":"Prevalence of Strongyloides in Northern Thailand and treatment with ivermectin vs albendazole","volume":"36","author":"P Nontasut","year":"2005","journal-title":"Southeast Asian J Trop Med Public Health"},{"key":"pone.0279766.ref017","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1179\/2047773214Y.0000000134","article-title":"Prevalence and risk factors of acquiring Strongyloides stercoralis infection among patients attending a tertiary hospital in Thailand.","volume":"108","author":"U Jongwutiwes","year":"2014","journal-title":"Pathog Glob Health"},{"key":"pone.0279766.ref018","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1186\/s12889-018-5871-1","article-title":"Current high prevalences of Strongyloides stercoralis and Opisthorchis viverrini infections in rural communities in northeast Thailand and associated risk factors","volume":"18","author":"P Laoraksawong","year":"2018","journal-title":"BMC Public Health"},{"key":"pone.0279766.ref019","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1186\/s12879-017-2723-z","article-title":"An eleven-year retrospective hospital-based study of epidemiological data regarding human strongyloidiasis in northeast Thailand","volume":"17","author":"TK Prasongdee","year":"2017","journal-title":"BMC Infect Dis"},{"key":"pone.0279766.ref020","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1186\/s12889-017-4486-2","article-title":"Prevalence of intestinal parasitic infection and associated risk factors among village health volunteers in rural communities of southern Thailand","volume":"17","author":"C Punsawad","year":"2017","journal-title":"BMC Public Health"},{"key":"pone.0279766.ref021","doi-asserted-by":"crossref","first-page":"779","DOI":"10.5372\/1905-7415.0806.357","article-title":"Brief communication (Original). National survey of helminthiasis in Thailand","volume":"8","author":"T Wongsaroj","year":"2014","journal-title":"Asian Biomed"},{"key":"pone.0279766.ref022","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1172\/JCI34261","article-title":"Helminth infections: the great neglected tropical diseases","volume":"118","author":"PJ Hotez","year":"2008","journal-title":"J Clin Invest"},{"key":"pone.0279766.ref023","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1016\/j.ijpara.2021.10.001","article-title":"Strongyloides genotyping: a review of methods and application in public health and population genetics","volume":"51","author":"RS Bradbury","year":"2021","journal-title":"Int J Parasitol"},{"key":"pone.0279766.ref024","first-page":"1","article-title":"The biology of Strongyloides spp","author":"ME Viney","year":"2015"},{"key":"pone.0279766.ref025","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.3389\/fmicb.2017.01162","article-title":"Geography, ethnicity or subsistence-specific variations in human microbiome composition and diversity","volume":"8","author":"VK Gupta","year":"2017","journal-title":"Front Microbiol"},{"key":"pone.0279766.ref026","unstructured":"Thai Meteorological Department. The Climate of Thailand. 2022. Available from: https:\/\/www.tmd.go.th\/en\/archive\/thailand_climate.pdf."},{"key":"pone.0279766.ref027","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1007\/s11205-005-1947-2","article-title":"Exploring the quality of life of people in North Eastern and Southern Thailand","volume":"78","author":"D Jongudomkarn","year":"2006","journal-title":"Soc Indic Res"},{"key":"pone.0279766.ref028","doi-asserted-by":"crossref","first-page":"11","DOI":"10.2149\/tmh1973.16.11","article-title":"A New Method to Detect Strongyloides stercoralis from human stool","volume":"16","author":"T Arakaki","year":"1988","journal-title":"Jpn J Trop Med Hyg"},{"key":"pone.0279766.ref029","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/0035-9203(86)90384-6","article-title":"The epidemiology and control of intestinal helminths in the Pulicat Lake region of Southern India. I. 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Edgar","year":"2011","journal-title":"Bioinformatics"},{"key":"pone.0279766.ref033","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1101\/gr.112730.110","article-title":"Chimeric 16S rRNA sequence formation and detection in Sanger and 454-pyrosequenced PCR amplicons","volume":"21","author":"BJ Haas","year":"2011","journal-title":"Genome Res"},{"key":"pone.0279766.ref034","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1038\/nmeth.2604","article-title":"UPARSE: highly accurate OTU sequences from microbial amplicon reads","volume":"10","author":"RC Edgar","year":"2013","journal-title":"Nat Methods"},{"key":"pone.0279766.ref035","doi-asserted-by":"crossref","first-page":"5261","DOI":"10.1128\/AEM.00062-07","article-title":"Naive Bayesian classifier for rapid assignment of rRNA sequences into the new bacterial taxonomy","volume":"73","author":"Q Wang","year":"2007","journal-title":"Appl Environ Microbiol"},{"key":"pone.0279766.ref036","doi-asserted-by":"crossref","first-page":"D590","DOI":"10.1093\/nar\/gks1219","article-title":"The SILVA ribosomal RNA gene database project: improved data processing and web-based tools","volume":"41","author":"C Quast","year":"2013","journal-title":"Nucleic Acids Res"},{"issue":"6","key":"pone.0279766.ref037","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1093\/bioinformatics\/btq041","article-title":"Identifying biologically relevant differences between metagenomic communities","volume":"26","author":"DH Parks","year":"2010","journal-title":"Bioinformatics"},{"key":"pone.0279766.ref038","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1017\/S0031182020000736","article-title":"Intestinal parasites in rural communities in Nan Province, Thailand: changes in bacterial gut microbiota associated with minute intestinal fluke infection","volume":"147","author":"A Prommi","year":"2020","journal-title":"Parasitology"},{"key":"pone.0279766.ref039","doi-asserted-by":"crossref","first-page":"15651","DOI":"10.1038\/s41598-018-33937-3","article-title":"A comprehensive analysis of the faecal microbiome and metabolome of Strongyloides stercoralis infected volunteers from a non-endemic area","volume":"8","author":"TP Jenkins","year":"2018","journal-title":"Sci Rep"},{"key":"pone.0279766.ref040","doi-asserted-by":"crossref","first-page":"e2880","DOI":"10.1371\/journal.pntd.0002880","article-title":"Helminth colonization is associated with increased diversity of the gut microbiota","volume":"8","author":"SC Lee","year":"2014","journal-title":"PLoS Negl Trop Dis"},{"key":"pone.0279766.ref041","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/B978-0-12-810541-2.00003-8","volume-title":"Gut Microbiota","author":"E Ishiguro","year":"2018"},{"issue":"1","key":"pone.0279766.ref042","doi-asserted-by":"crossref","first-page":"103644","DOI":"10.1016\/j.isci.2021.103644","article-title":"Gut Ruminococcaceae levels at baseline correlate with risk of antibiotic-associated diarrhea","volume":"25","author":"X Gu","year":"2021","journal-title":"iScience"},{"issue":"9","key":"pone.0279766.ref043","doi-asserted-by":"crossref","first-page":"R79","DOI":"10.1186\/gb-2012-13-9-r79","article-title":"Dysfunction of the intestinal microbiome in inflammatory bowel disease and treatment","volume":"13","author":"XC Morgan","year":"2012","journal-title":"Genome Biol"},{"issue":"3","key":"pone.0279766.ref044","doi-asserted-by":"crossref","first-page":"121","DOI":"10.12938\/bmfh.2021-054","article-title":"Investigation of gut microbiota and short-chain fatty acids in Strongyloides stercoralis-infected patients in a rural community","volume":"41","author":"HT Nguyen","year":"2022","journal-title":"Biosci Microbiota Food 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composition in irritable bowel syndrome patients: A pilot study","volume":"13","author":"A Altomare","year":"2021","journal-title":"Nutrients"},{"key":"pone.0279766.ref049","doi-asserted-by":"crossref","first-page":"1849998","DOI":"10.1080\/19490976.2020.1849998","article-title":"From correlation to causality: the case of Subdoligranulum","volume":"12","author":"M Van Hul","journal-title":"Gut Microbes"},{"issue":"Suppl 1","key":"pone.0279766.ref050","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1017\/S0007114514001275","article-title":"Exploring the influence of the gut microbiota and probiotics on health: a symposium report","volume":"112","author":"LV Thomas","year":"2014","journal-title":"Br J Nutr"},{"key":"pone.0279766.ref051","doi-asserted-by":"crossref","first-page":"105272","DOI":"10.1016\/j.micpath.2021.105272","article-title":"Altered diversity and composition of gut microbiota in patients with allergic rhinitis","volume":"161","author":"M-S Zhou","year":"2021","journal-title":"Microb Pathog"},{"key":"pone.0279766.ref052","doi-asserted-by":"crossref","first-page":"683743","DOI":"10.3389\/fcimb.2021.683743","article-title":"Gut microbiota, glucose, lipid, and water-electrolyte metabolism in children with nonalcoholic fatty liver disease","volume":"11","author":"X Pan","year":"2021","journal-title":"Front Cell Infect Microbiol"},{"key":"pone.0279766.ref053","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1002\/hep.26093","article-title":"Characterization of gut microbiomes in nonalcoholic steatohepatitis (NASH) patients: A connection between endogenous alcohol and NASH","volume":"57","author":"L Zhu","year":"2013","journal-title":"Hepatology"},{"key":"pone.0279766.ref054","first-page":"978","article-title":"Alterations in the intestinal microbiome (dysbiosis) as a predictor of relapse after infliximab withdrawal in Crohn\u02bcs disease: Inflamm Bowel Dis","volume":"1","author":"S Rajca","year":"2014"},{"key":"pone.0279766.ref055","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1093\/ecco-jcc\/jjw051","article-title":"Anti-TNF therapy response in patients with ulcerative colitis is associated with colonic antimicrobial peptide expression and microbiota composition","volume":"10","author":"MK Magnusson","year":"2016","journal-title":"J Crohns Colitis"},{"key":"pone.0279766.ref056","doi-asserted-by":"crossref","first-page":"e02120","DOI":"10.1128\/mBio.02120-17","article-title":"Fecal microbiota signatures are associated with response to ustekinumab therapy among Crohn\u2019s disease patients","volume":"9","author":"MK Doherty","year":"2018","journal-title":"mBio"},{"key":"pone.0279766.ref057","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1099\/ijs.0.63325-0","article-title":"Multilocus sequence phylogenetic study of the genus Haemophilus with description of Haemophilus pittmaniae sp. nov","volume":"55","author":"N N\u00f8rskov-Lauritsen","year":"2005","journal-title":"Int J Syst Evol Microbiol"},{"key":"pone.0279766.ref058","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1186\/1752-1947-6-120","article-title":"Haemophilus pittmaniae respiratory infection in a patient with siderosis: a case report.","volume":"6","author":"MB Boucher","year":"2012","journal-title":"J Med Case Reports"},{"key":"pone.0279766.ref059","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1186\/s12879-017-2430-9","article-title":"Pulmonary strongyloidiasis: assessment between manifestation and radiological findings in 16 severe strongyloidiasis cases","volume":"17","author":"D Nabeya","year":"2017","journal-title":"BMC Infect Dis"},{"key":"pone.0279766.ref060","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1533\/9781845696375.2.157","volume-title":"Biomaterials and Tissue Engineering in Urology","author":"DJ Stickler","year":"2009"},{"key":"pone.0279766.ref061","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1097\/00042737-200110000-00004","article-title":"A controlled, double-blind, randomized study on the efficacy of Lactobacillus plantarum 299V in patients with irritable bowel syndrome","volume":"13","author":"K Niedzielin","year":"2001","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"pone.0279766.ref062","doi-asserted-by":"crossref","first-page":"S6","DOI":"10.1016\/j.sjbs.2015.09.022","article-title":"In vitro importance of probiotic Lactobacillus plantarum related to medical field","volume":"23","author":"MV Arasu","year":"2016","journal-title":"Saudi J Biol Sci"},{"key":"pone.0279766.ref063","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/B978-0-12-811519-0.00006-6","volume-title":"Genetically Engineered Foods","author":"O Csutak","year":"2018"},{"key":"pone.0279766.ref064","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.4269\/ajtmh.17-0492","article-title":"Case report: Strongyloides stercoralis hyperinfection in a patient with chronic lymphocytic leukemia","volume":"97","author":"R Guerrero-Wooley","year":"2017","journal-title":"Am J Trop Med Hyg"},{"key":"pone.0279766.ref065","doi-asserted-by":"crossref","first-page":"e266","DOI":"10.1371\/journal.pntd.0000266","article-title":"The interplay between Entamoeba and enteropathogenic bacteria modulates epithelial cell damage","volume":"2","author":"JM Galv\u00e1n-Moroyoqui","year":"2008","journal-title":"PLoS Negl Trop Dis"},{"key":"pone.0279766.ref066","doi-asserted-by":"crossref","first-page":"8401","DOI":"10.1021\/jf201953v","article-title":"Use of Tetragenococcus halophilus as a starter culture for flavor improvement in fish sauce fermentation","volume":"59","author":"N Udomsil","year":"2011","journal-title":"J Agric Food 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Med"},{"key":"pone.0279766.ref070","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1038\/s41591-018-0160-1","article-title":"Depicting the composition of gut microbiota in a population with varied ethnic origins but shared geography","volume":"24","author":"M Deschasaux","year":"2018","journal-title":"Nat Med"},{"key":"pone.0279766.ref071","doi-asserted-by":"crossref","first-page":"88","DOI":"10.3390\/medicina56020088","article-title":"Nutritional status and the influence of the vegan diet on the gut microbiota and human health","volume":"56","author":"H Sakkas","year":"2020","journal-title":"Medicina"},{"key":"pone.0279766.ref072","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1007\/s10620-020-06091-y","article-title":"Tools for analysis of the microbiome","volume":"65","author":"J Galloway-Pe\u00f1a","year":"2020","journal-title":"Dig Dis 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