{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T21:19:18Z","timestamp":1767907158220,"version":"3.49.0"},"reference-count":21,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2022,12,30]],"date-time":"2022-12-30T00:00:00Z","timestamp":1672358400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"crossref","award":["NRF-2021R1A2C1005800"],"award-info":[{"award-number":["NRF-2021R1A2C1005800"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>We investigated the association of insulin administration method with the achievement of mean glucose \u2264 180 mg\/dL and neurological outcomes in out-of-hospital cardiac arrest (OHCA) survivors who had hyperglycemia after the return of spontaneous circulation. From a multicenter prospective registry, we extracted the data of adult OHCA survivors who underwent targeted temperature management (TTM) between 2015 and 2018. Blood glucose levels every 4 h after initiating TTM were obtained for 72 h. We divided insulin administration methods into three categories: subcutaneous (SQI), intravenous bolus (IBI), and continuous intravenous (CII). We calculated the mean glucose and standard deviation (SD) of glucose. The primary outcome was the achievement of mean glucose \u2264 180 mg\/dL. The secondary outcomes were the 6-month neurological outcome based on the Cerebral Performance Category (CPC) scale (good, CPC 1\u20132; poor, CPC 3\u20135), mean glucose, and SD of glucose. Of the 549 patients, 296 (53.9%) achieved mean glucose \u2264 180 mg\/dL, and 438 (79.8%) had poor neurological outcomes, 134 (24.4%), 132 (24.0), and 283 (51.5%) were in the SQI, IBI, and CII groups, respectively. The SQI (adjusted odds ratio [aOR], 0.848; 95% confidence intervals [CIs], 0.493\u20131.461) and IBI (aOR, 0.673; 95% CIs, 0.415\u20131.091) groups were not associated with mean glucose \u2264 180 mg\/dL and the SQI (aOR, 0.660; 95% CIs, 0.335\u20131.301) and IBI (aOR, 1.757; 95% CIs, 0.867\u20133.560) groups were not associated with poor neurological outcomes compared to the CII group. The CII (168 mg\/dL [147\u2013202]) group had the lowest mean glucose than the SQI (181 mg\/dL [156\u2013218]) and IBI (184 mg\/dL [162\u2013216]) groups. The CII (45.0[33.9\u201363.5]) group had a lower SD of glucose than the IBI (50.8 [39.1\u201372.0]) group. The insulin administration method was not associated with achieving mean glucose \u2264 180 mg\/dL and 6-month neurological outcomes.<\/jats:p>","DOI":"10.1371\/journal.pone.0279776","type":"journal-article","created":{"date-parts":[[2022,12,30]],"date-time":"2022-12-30T18:56:03Z","timestamp":1672426563000},"page":"e0279776","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":2,"title":["Association between insulin administration method and six-month neurological outcome in survivors of out-of-hospital cardiac arrest who underwent targeted temperature management"],"prefix":"10.1371","volume":"17","author":[{"given":"Dong Hun","family":"Lee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3571-9448","authenticated-orcid":true,"given":"Byung Kook","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong Soo","family":"Cho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong Hun","family":"Jung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyoung Youn","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3478-6967","authenticated-orcid":true,"given":"Kyung Woon","family":"Jeung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun Song","family":"Youn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3141-9413","authenticated-orcid":true,"given":"Soo Hyun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"on behalf of Korean Hypothermia Network Investigators","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2022,12,30]]},"reference":[{"key":"pone.0279776.ref001","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S0300-9572(03)00238-7","article-title":"A multiple logistic regression analysis of in-hospital factors related to survival at six months in patients resuscitated from out-of-hospital ventricular fibrillation.","volume":"59","author":"MB Skrifvars","year":"2003","journal-title":"Resuscitation."},{"key":"pone.0279776.ref002","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1097\/CCM.0000000000002367","article-title":"Dysglycemia, Glycemic Variability, and Outcome After Cardiac Arrest and Temperature Management at 33 degrees C and 36 degrees 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