{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T00:23:15Z","timestamp":1793146995738,"version":"4.5.0"},"reference-count":20,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2023,2,3]],"date-time":"2023-02-03T00:00:00Z","timestamp":1675382400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Purpose<\/jats:title>\n<jats:p>To determine the proportion of postmenopausal Thai women who would be classified as having high risk of fracture and eligible for anti-osteoporosis therapy according to the National Osteoporosis Foundation (NOF) criteria.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>Postmenopausal Thai women aged 40\u201390 years who had been screened for osteoporosis during 2014\u20132019 were recruited. Demographic data and osteoporosis risk factors were collected based on the Fracture Risk Assessment Tool (FRAX) questionnaire. Bone mineral density (BMD) at the femoral neck and lumbar spine measured using dual energy X-ray absorptiometry. Ten-year probabilities of hip and major osteoporotic fracture (MOF) were calculated based on the Thai FRAX model with BMD. The study\u2019s protocol was approved by the Institutional Ethical Committee (HE581241).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>A total of 3,280 postmenopausal women were included. The mean \u00b1 SD age was 63.6 \u00b1 10.1 years. A total of 170 (5.2%) participants had a history of hip and\/or vertebral fracture. After excluding these participants with fracture history, 699 (21.3%) had osteoporosis, 355 (10.8%) had osteopenia with high risk of fracture (FRAX 10-year probability of hip fracture \u2265 3% and\/or MOF \u2265 20%), 1192 (36.3%) had osteopenia with low risk of fracture (FRAX 10-year probability of hip fracture &lt; 3% and MOF &lt; 20%) and 864 (26.3%) had normal BMD. Taken together, a total of 1,224 (37.3%) participants would be eligible for anti-osteoporosis therapy (prior fracture, osteoporosis or osteopenia with high risk of fracture).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>The prevalence of Thai postmenopausal women who would be eligible for anti-osteoporosis therapy was 37.3%.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0279829","type":"journal-article","created":{"date-parts":[[2023,2,3]],"date-time":"2023-02-03T18:24:48Z","timestamp":1675448688000},"page":"e0279829","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":7,"title":["The proportion of Thai postmenopausal women who would be eligible for anti-osteoporosis therapy"],"prefix":"10.1371","volume":"18","author":[{"given":"Piyachat","family":"Chanidkul","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4075-0418","authenticated-orcid":true,"given":"Dueanchonnee","family":"Sribenjalak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6501-6180","authenticated-orcid":true,"given":"Nipith","family":"Charoenngam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chatlert","family":"Pongchaiyakul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2023,2,3]]},"reference":[{"issue":"5","key":"pone.0279829.ref001","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1007\/s001980170112","article-title":"The Burden of Osteoporotic Fractures: A Method for Setting Intervention Thresholds.","volume":"12","author":"JA Kanis","year":"2001","journal-title":"Osteoporosis International."},{"issue":"9","key":"pone.0279829.ref002","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1093\/oxfordjournals.aje.a116756","article-title":"III. Population-Based Study of Survival after Osteoporotic Fractures","volume":"137","author":"C Cooper","year":"1993","journal-title":"American Journal of Epidemiology"},{"issue":"10","key":"pone.0279829.ref003","doi-asserted-by":"crossref","first-page":"2359","DOI":"10.1007\/s00198-014-2794-2","article-title":"Clinician\u2019s Guide to Prevention and Treatment of Osteoporosis.","volume":"25","author":"F Cosman","year":"2014","journal-title":"Osteoporos Int."},{"issue":"2","key":"pone.0279829.ref004","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/nrrheum.2009.260","article-title":"Osteoporosis: impact on health and economics","volume":"6","author":"N Harvey","year":"2010","journal-title":"Nature Reviews Rheumatology"},{"issue":"1","key":"pone.0279829.ref005","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1177\/2151458510378105","article-title":"The 1-year mortality of patients treated in a hip fracture program for elders.","volume":"1","author":"S Schnell","year":"2010","journal-title":"Geriatr Orthop Surg Rehabil"},{"issue":"5","key":"pone.0279829.ref006","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1210\/jc.2019-00221","article-title":"Pharmacological Management of Osteoporosis in Postmenopausal Women: An Endocrine Society* Clinical Practice Guideline.","volume":"104","author":"R Eastell","year":"2019","journal-title":"The Journal of Clinical Endocrinology & Metabolism."},{"issue":"3","key":"pone.0279829.ref007","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1007\/s00198-016-3868-0","article-title":"Imminent risk of fracture after fracture.","volume":"28","author":"H Johansson","year":"2017","journal-title":"Osteoporos Int."},{"issue":"1","key":"pone.0279829.ref008","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1186\/s13018-021-02821-8","article-title":"Global prevalence of osteoporosis among the world older adults: a comprehensive systematic review and meta-analysis","volume":"16","author":"N Salari","year":"2021","journal-title":"Journal of Orthopaedic Surgery and Research"},{"issue":"9696","key":"pone.0279829.ref009","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1016\/S0140-6736(09)61460-4","article-title":"Ageing populations: the challenges ahead","volume":"374","author":"K Christensen","year":"2009","journal-title":"Lancet"},{"issue":"4","key":"pone.0279829.ref010","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1007\/s00198-007-0543-5","article-title":"FRAX and the assessment of fracture probability in men and women from the UK.","volume":"19","author":"JA Kanis","year":"2008","journal-title":"Osteoporos Int"},{"issue":"1","key":"pone.0279829.ref011","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1007\/s11657-019-0613-2","article-title":"Temporal changes in access to FRAX\u00ae in Thailand between 2010 and 2018.","volume":"14","author":"P Chotiyarnwong","year":"2019","journal-title":"Arch Osteoporos."},{"issue":"1","key":"pone.0279829.ref012","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s11657-021-00962-1","article-title":"FRAX-based intervention thresholds in eight Eurasian countries: Armenia, Belarus, Georgia, Kazakhstan, the Kyrgyz Republic, Moldova, the Russian Federation, and Uzbekistan.","volume":"16","author":"O Lesnyak","year":"2021","journal-title":"Arch Osteoporos"},{"issue":"4","key":"pone.0279829.ref013","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.afos.2019.12.002","article-title":"The diversity of Fracture Risk Assessment Tool (FRAX)-based intervention thresholds in Asia","volume":"5","author":"S. Lekamwasam","year":"2019","journal-title":"Osteoporos Sarcopenia"},{"issue":"1","key":"pone.0279829.ref014","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s00198-009-1127-3","article-title":"Application of the National Osteoporosis Foundation Guidelines to postmenopausal women and men: the Framingham Osteoporosis Study.","volume":"21","author":"SD Berry","year":"2010","journal-title":"Osteoporos Int."},{"issue":"1","key":"pone.0279829.ref015","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s00198-009-1034-7","article-title":"The potential impact of new National Osteoporosis Foundation guidance on treatment patterns.","volume":"21","author":"B Dawson-Hughes","year":"2010","journal-title":"Osteoporosis International"},{"issue":"6","key":"pone.0279829.ref016","doi-asserted-by":"crossref","first-page":"e0252592","DOI":"10.1371\/journal.pone.0252592","article-title":"Burden of osteoporosis in Vietnam: An analysis of population risk.","volume":"16","author":"DK Hoang","year":"2021","journal-title":"PLOS ONE."},{"issue":"1","key":"pone.0279829.ref017","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s11657-016-0278-z","article-title":"A systematic review of intervention thresholds based on FRAX: A report prepared for the National Osteoporosis Guideline Group and the International Osteoporosis Foundation.","volume":"11","author":"JA Kanis","year":"2016","journal-title":"Arch Osteoporos"},{"key":"pone.0279829.ref018","first-page":"S332","article-title":"Accuracy of application of who fracture risk assessment (FRAX\u2122) for prediction hio fracture in Khon Kaen hospital Thailand.","volume":"23","author":"T Sangkomkamhang","year":"2012","journal-title":"Osteoporosis International."},{"key":"pone.0279829.ref019","first-page":"S333","article-title":"Prediction of fragility fracture with the FRAX tool in postmenopausal woman in Thailand.","volume":"23","author":"US Sangkomkamhang","year":"2012","journal-title":"Osteoporosis International"},{"issue":"1","key":"pone.0279829.ref020","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s11657-022-01058-0","article-title":"An optimal intervention threshold of FRAX in postmenopausal Thai women.","volume":"17","author":"D Sribenjalak","year":"2022","journal-title":"Arch Osteoporos"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0279829","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,3]],"date-time":"2023-02-03T18:25:05Z","timestamp":1675448705000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0279829"}},"subtitle":[],"editor":[{"given":"Inge","family":"Roggen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2023,2,3]]},"references-count":20,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2023,2,3]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0279829","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,3]]}}}