{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T00:53:51Z","timestamp":1792457631920,"version":"4.5.0"},"reference-count":57,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2023,1,6]],"date-time":"2023-01-06T00:00:00Z","timestamp":1672963200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"NCI","award":["P01 CA168530"],"award-info":[{"award-number":["P01 CA168530"]}]},{"name":"NCI","award":["U01 CA164973"],"award-info":[{"award-number":["U01 CA164973"]}]},{"name":"NCI","award":["U01 CA164973"],"award-info":[{"award-number":["U01 CA164973"]}]},{"name":"NCI","award":["U01 CA164973"],"award-info":[{"award-number":["U01 CA164973"]}]},{"name":"NCI","award":["P30 CA071789"],"award-info":[{"award-number":["P30 CA071789"]}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1TR000130"],"award-info":[{"award-number":["UL1TR000130"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"name":"NCI","award":["T32 CA229100"],"award-info":[{"award-number":["T32 CA229100"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>Few studies have explored the genetic underpinnings of intra-abdominal visceral fat deposition, which varies substantially by sex and race\/ethnicity. Among 1,787 participants in the Multiethnic Cohort (MEC)-Adiposity Phenotype Study (MEC-APS), we conducted a genome-wide association study (GWAS) of the percent visceral adiposity tissue (VAT) area out of the overall abdominal area, averaged across L1-L5 (%VAT), measured by abdominal magnetic resonance imaging (MRI). A genome-wide significant signal was found on chromosome 2q14.3 in the sex-combined GWAS (lead variant rs79837492: Beta per effect allele = -4.76; P = 2.62 \u00d7 10<jats:sup>\u22128<\/jats:sup>) and in the male-only GWAS (lead variant rs2968545: (Beta = -6.50; P = 1.09 \u00d7 10<jats:sup>\u22129<\/jats:sup>), and one suggestive variant was found at 13q12.11 in the female-only GWAS (rs79926925: Beta = 6.95; P = 8.15 \u00d7 10<jats:sup>\u22128<\/jats:sup>). The negatively associated variants were most common in European Americans (T allele of rs79837492; 5%) and African Americans (C allele of rs2968545; 5%) and not observed in Japanese Americans, whereas the positively associated variant was most common in Japanese Americans (C allele of rs79926925, 5%), which was all consistent with the racial\/ethnic %VAT differences. In a validation step among UK Biobank participants (N = 23,699 of mainly British and Irish ancestry) with MRI-based VAT volume, both rs79837492 (Beta = -0.026, P = 0.019) and rs2968545 (Beta = -0.028, P = 0.010) were significantly associated in men only (n = 11,524). In the MEC-APS, the association between rs79926925 and plasma sex hormone binding globulin levels reached statistical significance in females, but not in males, with adjustment for total adiposity (Beta = -0.24; P = 0.028), on the log scale. Rs79837492 and rs2968545 are located in intron 5 of <jats:italic>CNTNAP5<\/jats:italic>, and rs79926925, in an intergenic region between <jats:italic>GJB6<\/jats:italic> and <jats:italic>CRYL1<\/jats:italic>. These novel findings differing by sex and racial\/ethnic group warrant replication in additional diverse studies with direct visceral fat measurements.<\/jats:p>","DOI":"10.1371\/journal.pone.0279932","type":"journal-article","created":{"date-parts":[[2023,1,6]],"date-time":"2023-01-06T18:42:13Z","timestamp":1673030533000},"page":"e0279932","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":7,"title":["Genome-wide association study of abdominal MRI-measured visceral fat: The multiethnic cohort adiposity phenotype study"],"prefix":"10.1371","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0455-2131","authenticated-orcid":true,"given":"Samantha A.","family":"Streicher","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Unhee","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. 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