{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T15:41:08Z","timestamp":1775230868844,"version":"3.50.1"},"reference-count":45,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2023,1,18]],"date-time":"2023-01-18T00:00:00Z","timestamp":1674000000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008436","name":"Ernst und Berta Grimmke Stiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008436","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Purpose<\/jats:title>\n<jats:p>To prospectively assess the effect of a single and regular application of either a cationic nanoemulsion of mineral oil (CN) or perfluorohexyloctane (F6H8) on the lipid layer of the tear film and higher order aberrations (HOA) in patients with Dry Eye Disease (DED).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>Fifty-seven patients with a lipid layer thickness (LLT) \u2264 75 interferometric colour units (ICU) were included in the study. In group A (20 patients) the effect of a single drop of F6H8 or CN on HOA and LLT was assessed immediately after application and up to two hours later. For long term effects (Group B) 37 patients applied CN or F6H8 five times a day for 12 weeks. Measurement of LLT, HOA, non-invasive-tear-break-up-time (NIBUT) and meibography were assessed prior to as well as at 4 weeks and 12 weeks after initiation of treatment. Our study is registered in the \u201cGerman Clinical Trials Register\u201d under the trial number: DRKS00028696.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>CN led to an increase of the LLT from 46.8 \u00b1 16.9 ICU to 76.3 \u00b1 23.5 ICU (p = 0.021) and to an increase of HOA from 0.43 \u00b1 0.06 \u03bcm to 0.48 \u00b1 0.08 \u03bcm immediately after application (p = 0.027). There was no correlation between the increase of LLT and HOA (r = -0.04; p = 0.90). In group B an increase of LLT was observed in the F6H8 group from 45.8 \u00b1 8.8 ICU at baseline to 66.7 \u00b1 19.5 ICU at 12 weeks (p = 0.002). No changes of HOA were measured throughout the observation period in group B. After 12 weeks CN increased NIBUT from 9.9 \u00b1 5.3 seconds to 15.5 \u00b1 5.6 seconds (p = 0.04). F6H8 increased NIBUT from 12.4 \u00b1 5.9 seconds to 16.9 \u00b1 4.7 seconds (p = 0.02) after 12 weeks.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>CN leads to a short-term increase in LLT and HOA, but only immediately after application. In contrast F6H8 does lead to an increase of LLT after regular long-term use but has no effect on HOA. The regular application of lipid-based products does not seem to decrease the quality of vision as measured in HOA. Instead, CN and F6H8, both are able to stabilize the tear film after regular application.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0279977","type":"journal-article","created":{"date-parts":[[2023,1,18]],"date-time":"2023-01-18T18:36:42Z","timestamp":1674067002000},"page":"e0279977","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":17,"title":["The influence of a mineral oil cationic nanoemulsion or perfluorohexyloctane on the tear film lipid layer and higher order aberrations"],"prefix":"10.1371","volume":"18","author":[{"given":"Kirsten Julia","family":"Habbe","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8977-4261","authenticated-orcid":true,"given":"Andreas","family":"Frings","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amr","family":"Saad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerd","family":"Geerling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2023,1,18]]},"reference":[{"issue":"3","key":"pone.0279977.ref001","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.jtos.2017.05.008","article-title":"TFOS DEWS II Definition and Classification Report","volume":"15","author":"J.P. 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Lee","year":"2012","journal-title":"Optom Vis Sci"},{"issue":"3","key":"pone.0279977.ref008","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.jtos.2017.05.006","article-title":"TFOS DEWS II Management and Therapy Report","volume":"15","author":"L. Jones","year":"2017","journal-title":"Ocul Surf"},{"issue":"41","key":"pone.0279977.ref009","first-page":"R635","article-title":"Nanoemulsions: formation, structure, and physical properties","volume":"18","author":"T.G. Mason","year":"2006","journal-title":"Journal of Physics: Condensed Matter"},{"issue":"9","key":"pone.0279977.ref010","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1089\/jop.2017.0052","article-title":"Relevance of Lipid-Based Products in the Management of Dry Eye Disease","volume":"33","author":"J.S. Garrigue","year":"2017","journal-title":"J Ocul Pharmacol Ther"},{"issue":"7","key":"pone.0279977.ref011","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18071558","article-title":"Surface Chemistry Interactions of Cationorm with Films by Human Meibum and Tear Film Compounds","volume":"18","author":"G.A. Georgiev","year":"2017","journal-title":"Int J Mol Sci"},{"issue":"9","key":"pone.0279977.ref012","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1089\/jop.2017.0042","article-title":"Semifluorinated Alkane Eye Drops for Treatment of Dry Eye Disease Due to Meibomian Gland Disease","volume":"33","author":"P. Steven","year":"2017","journal-title":"J Ocul Pharmacol Ther"},{"issue":"1","key":"pone.0279977.ref013","doi-asserted-by":"crossref","first-page":"59","DOI":"10.3928\/1081597X-20090101-08","article-title":"Variability of higher order wavefront aberrations after blinks","volume":"25","author":"K. Hagyo","year":"2009","journal-title":"J Refract Surg"},{"issue":"10","key":"pone.0279977.ref014","first-page":"909","article-title":"Application of wavefront analysis in clinical and scientific settings. From irregular astigmatism to aberrations of a higher order\u2014Part I: Basic principles","volume":"104","author":"J. Buhren","year":"2007","journal-title":"Ophthalmologe"},{"issue":"7","key":"pone.0279977.ref015","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1097\/ICO.0b013e318191b870","article-title":"The relationship between dry eye symptoms and lipid layer thickness","volume":"28","author":"C.A. Blackie","year":"2009","journal-title":"Cornea"},{"issue":"5","key":"pone.0279977.ref016","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/j.ophtha.2007.06.031","article-title":"Noncontact infrared meibography to document age-related changes of the meibomian glands in a normal population","volume":"115","author":"R. 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Agarwal","year":"2019","journal-title":"Ocul Surf"},{"key":"pone.0279977.ref025","article-title":"Influence of Perfluorohexyloctane Eye Drops on Tear Film Thickness in Patients with Mild to Moderate Dry Eye Disease: A Randomized Controlled Clinical Trial","author":"D. Schmidl","year":"2020","journal-title":"J Ocul Pharmacol Ther"},{"issue":"11","key":"pone.0279977.ref026","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1136\/bjo.2008.143750","article-title":"A cleaning solution for silicone intraocular lenses: \"sticky silicone oil\"","volume":"92","author":"Y. Liang","year":"2008","journal-title":"Br J Ophthalmol"},{"issue":"4","key":"pone.0279977.ref027","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1167\/iovs.10-6997c","article-title":"The international workshop on meibomian gland dysfunction: report of the subcommittee on anatomy, physiology, and pathophysiology of the meibomian gland","volume":"52","author":"E. Knop","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"5","key":"pone.0279977.ref028","doi-asserted-by":"crossref","first-page":"L1018","DOI":"10.1152\/ajplung.2000.278.5.L1018","article-title":"In vitro cellular effects of perfluorochemicals correlate with their lipid solubility","volume":"278","author":"V.V. Obraztsov","year":"2000","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"issue":"2","key":"pone.0279977.ref029","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/S0886-3350(99)00350-8","article-title":"Silicone oil removal from a silicone intraocular lens with perfluorohexyloctane","volume":"26","author":"D. 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Amrane","year":"2014","journal-title":"J Fr Ophtalmol"},{"issue":"1","key":"pone.0279977.ref032","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/sj.eye.6700224","article-title":"Correlation of lipid layer thickness measurements with fluorescein tear film break-up time and Schirmer\u2019s test","volume":"17","author":"M.A. Isreb","year":"2003","journal-title":"Eye (Lond)"},{"key":"pone.0279977.ref033","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/s12886-015-0036-9","article-title":"Intra-observer and inter-observer repeatability of ocular surface interferometer in measuring lipid layer thickness","volume":"15","author":"Y. 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