{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T19:56:50Z","timestamp":1772481410324,"version":"3.50.1"},"reference-count":83,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2023,1,6]],"date-time":"2023-01-06T00:00:00Z","timestamp":1672963200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Science and Engineering Research Council of Canada","doi-asserted-by":"crossref","award":["RGPIN-2017-03728"],"award-info":[{"award-number":["RGPIN-2017-03728"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>The goal of this study was to determine if 10-min of anodal transcranial direct current stimulation (a-tDCS) to the motor cortex (M1) is capable of modulating quadriceps isometric maximal voluntary contraction (MVC) force or fatigue endurance contralateral or ipsilateral to the stimulation site.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>In a randomized, cross-over design, 16 (8 females) individuals underwent two sessions of a-tDCS and two sham tDCS (s-tDCS) sessions targeting the left M1 (all participants were right limb dominant), with testing of either the left (ipsilateral) or right (contralateral) quadriceps. Knee extensor (KE) MVC force was recorded prior to and following the a-tDCS and s-tDCS protocols. Additionally, a repetitive MVC fatiguing protocol (12 MVCs with work-rest ratio of 5:10-s) was completed following each tDCS protocol.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>There was a significant interaction effect for stimulation condition x leg tested x time [<jats:italic>F<\/jats:italic><jats:sub>(1,60)<\/jats:sub> = 7.156, <jats:italic>p<\/jats:italic> = 0.010, \u03b7p<jats:sup>2<\/jats:sup> = 0.11], which revealed a significant absolute KE MVC force reduction in the contralateral leg following s-tDCS (p &lt; 0.001, d = 1.2) and in the ipsilateral leg following a-tDCS (p &lt; 0.001, d = 1.09). A significant interaction effect for condition x leg tested [<jats:italic>F<\/jats:italic><jats:sub>(1,56)<\/jats:sub> = 8.12, <jats:italic>p<\/jats:italic> = 0.006, \u03b7p<jats:sup>2<\/jats:sup> = 0.13], showed a significantly lower ipsilateral quadriceps (to tDCS) relative MVC force with a-tDCS, versus s-tDCS [<jats:italic>t<\/jats:italic>(15) = -3.07, <jats:italic>p<\/jats:italic> = 0.016, <jats:italic>d<\/jats:italic> = -0.77]. There was no significant difference between the relative contralateral quadriceps (to tDCS) MVC force for a-tDCS and s-tDCS. Although there was an overall significant [<jats:italic>F<\/jats:italic><jats:sub>(1,56)<\/jats:sub> = 8.36, <jats:italic>p<\/jats:italic> &lt; 0.001] 12.1% force decrease between the first and twelfth MVC repetitions, there were no significant main or interaction effects for fatigue index force.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>a-tDCS may be ineffective at increasing maximal force or endurance and instead may be detrimental to quadriceps force production.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0280129","type":"journal-article","created":{"date-parts":[[2023,1,6]],"date-time":"2023-01-06T18:42:39Z","timestamp":1673030559000},"page":"e0280129","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":7,"title":["Reduced isometric knee extensor force following anodal transcranial direct current stimulation of the ipsilateral motor 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