{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:31:21Z","timestamp":1787167881756,"version":"build-2736575974"},"reference-count":50,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2023,1,31]],"date-time":"2023-01-31T00:00:00Z","timestamp":1675123200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Fonds R\u00e9gional Recherche Innovation - FRRI Hauts-de-France"},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To compare two agents that can induce a rat model of temporomandibular joint osteoarthritis (TMJOA) by chemical induction: monosodium iodoacetate (MIA) and collagenase type 2 (Col-2). We wished to ascertain the best agent for assessing drug-delivery systems (DDSs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>Male Wistar rats underwent intra-articular injection with MIA or Col-2. They were manipulated for 30 days. The head withdrawal threshold (HWT), immunohistological assessment, and positron emission tomography (PET) were used to evaluate the relevance of our models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>For both the MIA and Col-2 groups, pain persisted for 30 days after injection. Change in the HWT showed that Col-2 elicited a strong action initially that decreased progressively. MIA had a constant action upon pain behavior. Histology of TMJ tissue from both groups showed progressive degradation of TMJ components.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>MIA and Col-2 induced orofacial pain by their local chemical action on TMJs. However, based on a prolonged and greater sustained effect on the pain threshold, persistent histological changes, and imaging results, MIA appeared to be more suitable for creation of a rat model of TMJOA for the study of DDSs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0281135","type":"journal-article","created":{"date-parts":[[2023,1,31]],"date-time":"2023-01-31T13:26:24Z","timestamp":1675171584000},"page":"e0281135","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":10,"title":["Comparison of chemical-induced temporomandibular osteoarthritis rat models (monosodium iodoacetate versus collagenase type II) for the study of prolonged drug delivery systems"],"prefix":"10.1371","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3391-1025","authenticated-orcid":true,"given":"Florent","family":"Barry","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Chai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7555-0109","authenticated-orcid":true,"given":"Henry","family":"Chijcheapaza-Flores","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Jos\u00e9","family":"Garcia-Fernandez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Blanchemain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7391-2121","authenticated-orcid":true,"given":"Romain","family":"Nicot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2023,1,31]]},"reference":[{"issue":"2","key":"pone.0281135.ref001","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1007\/s00784-020-03710-w","article-title":"Prevalence of temporomandibular joint disorders: a systematic review and meta-analysis","volume":"25","author":"LF Valesan","year":"2021","journal-title":"Clin Oral Investig"},{"key":"pone.0281135.ref002","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/08869634.2022.2137129","article-title":"Prevalence of temporomandibular disorders in people with multiple sclerosis: A systematic review and meta-analysis","author":"G Minervini","year":"2022","journal-title":"Cranio"},{"issue":"1","key":"pone.0281135.ref003","doi-asserted-by":"crossref","first-page":"6","DOI":"10.11607\/jop.1151","article-title":"Diagnostic Criteria for Temporomandibular Disorders (DC\/TMD) for Clinical and Research Applications: recommendations of the International RDC\/TMD Consortium Network* and Orofacial Pain Special Interest Group\u2020","volume":"28","author":"E Schiffman","year":"2014","journal-title":"J Oral Facial Pain Headache"},{"issue":"6","key":"pone.0281135.ref004","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1111\/joor.12480","article-title":"The role of molecular pain biomarkers in temporomandibular joint internal derangement","volume":"44","author":"M. Ernberg","year":"2017","journal-title":"J Oral Rehabil. juin"},{"issue":"4","key":"pone.0281135.ref005","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1067\/moe.2000.108801","article-title":"Temporomandibular joint pain: relationship to internal derangement type, osteoarthrosis, and synovial fluid mediator level of tumor necrosis factor-alpha","volume":"90","author":"R Emshoff","year":"2000","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"issue":"4","key":"pone.0281135.ref006","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1177\/154405910808700406","article-title":"Degenerative disorders of the temporomandibular joint: etiology, diagnosis, and treatment","volume":"87","author":"E Tanaka","year":"2008","journal-title":"J Dent Res"},{"issue":"5","key":"pone.0281135.ref007","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1177\/0022034515574770","article-title":"Current understanding of pathogenesis and treatment of TMJ osteoarthritis","volume":"94","author":"XD Wang","year":"2015","journal-title":"J Dent Res"},{"issue":"7","key":"pone.0281135.ref008","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/j.adaj.2019.03.023","article-title":"Clinical predictors of persistent temporomandibular disorder in people with first-onset temporomandibular disorder: A prospective case-control study","volume":"150","author":"CB Meloto","year":"2019","journal-title":"J Am Dent Assoc"},{"issue":"11 Suppl","key":"pone.0281135.ref009","doi-asserted-by":"crossref","first-page":"T27","DOI":"10.1016\/j.jpain.2011.09.001","article-title":"Clinical findings and pain symptoms as potential risk factors for chronic TMD: descriptive data and empirically identified domains from the OPPERA case-control study","volume":"12","author":"R Ohrbach","year":"2011","journal-title":"J Pain. nov"},{"key":"pone.0281135.ref010","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/1472-6815-11-5","article-title":"Signs and symptoms of temporomandibular joint disorders related to the degree of mouth opening and hearing loss","volume":"11","author":"P Kitsoulis","year":"2011","journal-title":"BMC Ear Nose Throat Disord"},{"issue":"2","key":"pone.0281135.ref011","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/s10266-019-00439-1","article-title":"Estrogen signaling impacts temporomandibular joint and periodontal disease pathology","volume":"108","author":"JL Robinson","year":"2020","journal-title":"Odontology. avr"},{"issue":"5","key":"pone.0281135.ref012","article-title":"Interdisciplinary Approach to the Temporomandibular Joint Osteoarthritis-Review of the Literature","volume":"56","author":"M Derwich","year":"2020","journal-title":"Medicina (Kaunas)"},{"issue":"6","key":"pone.0281135.ref013","doi-asserted-by":"crossref","first-page":"e393","DOI":"10.11607\/jomi.te20","article-title":"Temporomandibular disorders: a review of etiology, clinical management, and tissue engineering strategies","volume":"28","author":"MK Murphy","year":"2013","journal-title":"Int J Oral Maxillofac Implants"},{"issue":"4","key":"pone.0281135.ref014","doi-asserted-by":"crossref","first-page":"739","DOI":"10.3390\/healthcare10040739","article-title":"Effects of Occlusal Splints on Spinal Posture in Patients with Temporomandibular Disorders: A Systematic Review","volume":"10","author":"M Ferrillo","year":"2022","journal-title":"Healthcare (Basel)"},{"issue":"2","key":"pone.0281135.ref015","doi-asserted-by":"crossref","first-page":"253","DOI":"10.3390\/prosthesis4020025","article-title":"Prosthodontic Treatment in Patients with Temporomandibular Disorders and Orofacial Pain and\/or Bruxism: A Review of the Literature","volume":"4","author":"G Minervini","year":"2022","journal-title":"Prosthesis"},{"key":"pone.0281135.ref016","unstructured":"Efficacy of conservative approaches on pain relief in patients with temporomandibular joint disorders: a systematic review with network meta-analysis: CRANIO\u00ae: Vol 0, No 0 [Internet]. [cit\u00e9 6 janv 2023]. https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/08869634.2022.2126079."},{"issue":"3","key":"pone.0281135.ref017","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1179\/crn.2010.023","article-title":"Hyaluronic acid in the treatment of TMJ disorders: a systematic review of the literature","volume":"28","author":"D Manfredini","year":"2010","journal-title":"Cranio"},{"issue":"3","key":"pone.0281135.ref018","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1093\/rheumatology\/40.3.336","article-title":"The role of hyaluronic acid in protecting surface-active phospholipids from lysis by exogenous phospholipase A(2)","volume":"40","author":"DW Nitzan","year":"2001","journal-title":"Rheumatology (Oxford)"},{"issue":"3","key":"pone.0281135.ref019","doi-asserted-by":"crossref","first-page":"373.e1","DOI":"10.1016\/j.joms.2019.10.016","article-title":"Multiple Treatment Meta-Analysis of Intra-Articular Injection for Temporomandibular Osteoarthritis","volume":"78","author":"Y Liu","year":"2020","journal-title":"J Oral Maxillofac Surg"},{"issue":"2","key":"pone.0281135.ref020","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.ymeth.2008.09.001","article-title":"Emerging intra-articular drug delivery systems for the temporomandibular joint","volume":"47","author":"PM Mountziaris","year":"2009","journal-title":"Methods. f\u00e9vr"},{"key":"pone.0281135.ref021","article-title":"Systematic review of studies on drug-delivery systems for management of temporomandibular-joint osteoarthritis","author":"F Barry","year":"2021","journal-title":"J Stomatol Oral Maxillofac Surg"},{"key":"pone.0281135.ref022","article-title":"Intra-articular biomaterials-assisted delivery to treat temporomandibular joint disorders","volume":"9","author":"K Dashnyam","year":"2018","journal-title":"J Tissue Eng. d\u00e9c"},{"key":"pone.0281135.ref023","article-title":"Hyaluronic acid\/parecoxib-loaded PLGA microspheres for therapy of temporomandibular disorders","author":"D Zhu","year":"2020","journal-title":"Curr Drug Deliv"},{"issue":"23\u201324","key":"pone.0281135.ref024","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1016\/j.lfs.2012.04.035","article-title":"15d-PGJ2-loaded in nanocapsules enhance the antinociceptive properties into rat temporomandibular hypernociception","volume":"90","author":"JT Clemente-Napimoga","year":"2012","journal-title":"Life Sci"},{"issue":"2","key":"pone.0281135.ref025","doi-asserted-by":"crossref","first-page":"025003","DOI":"10.1088\/1758-5090\/8\/2\/025003","article-title":"Micro-precise spatiotemporal delivery system embedded in 3D printing for complex tissue regeneration","volume":"8","author":"S Tarafder","year":"2016","journal-title":"Biofabrication"},{"issue":"3","key":"pone.0281135.ref026","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1097\/SCS.0000000000002588","article-title":"Chitosan-Based Thermosensitive Hydrogel for Controlled Drug Delivery to the Temporomandibular Joint","volume":"27","author":"WM Talaat","year":"2016","journal-title":"J Craniofac Surg"},{"key":"pone.0281135.ref027","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.jconrel.2017.06.031","article-title":"Microneedles enhance topical delivery of 15-deoxy-\u039412,14-prostaglandin J2 and reduce nociception in temporomandibular joint of rats","volume":"265","author":"CG Macedo","year":"2017","journal-title":"J Control Release"},{"issue":"1","key":"pone.0281135.ref028","doi-asserted-by":"crossref","first-page":"11160","DOI":"10.1038\/s41598-019-47486-w","article-title":"Improved efficacy of naproxen-loaded NLC for temporomandibular joint administration","volume":"9","author":"VA Guilherme","year":"2019","journal-title":"Sci Rep"},{"issue":"6","key":"pone.0281135.ref029","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1002\/cre2.327","article-title":"Electroporation technique for joint pain\u2014Pilot feasibility study on TMD patients","volume":"6","author":"GM Tartaglia","year":"2020","journal-title":"Clin Exp Dent Res"},{"key":"pone.0281135.ref030","doi-asserted-by":"crossref","first-page":"119383","DOI":"10.1016\/j.ijpharm.2020.119383","article-title":"Poloxamer micellar system for intra-articular injection of 15-deoxy-\u039412,14-prostaglandin J2 with improved bioavailability and anti-inflammatory properties in the temporomandibular joint of rats","volume":"583","author":"HB Abdalla","year":"2020","journal-title":"Int J Pharm"},{"issue":"3","key":"pone.0281135.ref031","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1089\/ten.teb.2017.0341","article-title":"Preclinical Animal Models for Temporomandibular Joint Tissue Engineering","volume":"24","author":"AJ Almarza","year":"2018","journal-title":"Tissue Eng Part B Rev"},{"key":"pone.0281135.ref032","article-title":"Systematic Review of Rat Models With Temporomandibular Osteoarthritis Suitable for the Study of Emerging Prolonged Intra-Articular Drug Delivery Systems","author":"R Nicot","year":"2021","journal-title":"J Oral Maxillofac Surg"},{"issue":"6","key":"pone.0281135.ref033","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1016\/j.joca.2015.02.010","article-title":"Injury of primary afferent neurons may contribute to osteoarthritis induced pain: an experimental study using the collagenase model in rats","volume":"23","author":"S Ad\u00e3es","year":"2015","journal-title":"Osteoarthritis Cartilage"},{"issue":"11","key":"pone.0281135.ref034","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1292\/jvms.65.1195","article-title":"Sodium iodoacetate-induced experimental osteoarthritis and associated pain model in rats","volume":"65","author":"K Kobayashi","year":"2003","journal-title":"J Vet Med Sci"},{"key":"pone.0281135.ref035","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/978-1-61779-561-9_18","article-title":"The monosodium iodoacetate model of osteoarthritis pain in the rat","volume":"851","author":"CL Marker","year":"2012","journal-title":"Methods Mol Biol"},{"issue":"9","key":"pone.0281135.ref036","doi-asserted-by":"crossref","first-page":"e45036","DOI":"10.1371\/journal.pone.0045036","article-title":"Progression of cartilage degradation, bone resorption and pain in rat temporomandibular joint osteoarthritis induced by injection of iodoacetate","volume":"7","author":"XD Wang","year":"2012","journal-title":"PLoS ONE"},{"key":"pone.0281135.ref037","article-title":"Chronic Pain Causes Peripheral and Central Responses in MIA-Induced TMJOA Rats","author":"H Jiang","year":"2021","journal-title":"Cell Mol Neurobiol"},{"issue":"9","key":"pone.0281135.ref038","doi-asserted-by":"crossref","first-page":"2036","DOI":"10.1097\/j.pain.0000000000001598","article-title":"Females have greater susceptibility to develop ongoing pain and central sensitization in a rat model of temporomandibular joint pain","volume":"160","author":"S Sannajust","year":"2019","journal-title":"Pain. sept"},{"key":"pone.0281135.ref039","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.biomaterials.2019.02.006","article-title":"MSC exosomes alleviate temporomandibular joint osteoarthritis by attenuating inflammation and restoring matrix homeostasis","volume":"200","author":"S Zhang","year":"2019","journal-title":"Biomaterials"},{"issue":"9","key":"pone.0281135.ref040","doi-asserted-by":"crossref","first-page":"3927","DOI":"10.3390\/app11093927","article-title":"Type I Collagen-Based Devices to Treat Nerve Injuries after Oral Surgery Procedures","volume":"11","author":"A Roccuzzo","year":"2021","journal-title":"A Systematic Review. Applied Sciences"},{"issue":"1","key":"pone.0281135.ref041","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1080\/08869634.2003.11746230","article-title":"Changes in urinary bone resorption markers (pyridinoline, deoxypyridinoline) resulting from experimentally-induced osteoarthritis in the temporomandibular joint of rats","volume":"21","author":"M Imada","year":"2003","journal-title":"Cranio"},{"issue":"5","key":"pone.0281135.ref042","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.archoralbio.2014.02.016","article-title":"Expression of ADAMTs-5 and TIMP-3 in the condylar cartilage of rats induced by experimentally created osteoarthritis","volume":"59","author":"W Li","year":"2014","journal-title":"Arch Oral Biol"},{"issue":"2","key":"pone.0281135.ref043","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1515\/pjvs-2017-0025","article-title":"Injection in temporomandibular joint of rats. Description of technical protocol","volume":"20","author":"R Fuentes","year":"2017","journal-title":"Pol J Vet Sci"},{"issue":"3","key":"pone.0281135.ref044","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1053\/joca.1998.0110","article-title":"Intra-articular injection of collagenase induces experimental osteoarthritis in mature rabbits","volume":"6","author":"T Kikuchi","year":"1998","journal-title":"Osteoarthritis Cartilage. mai"},{"issue":"3","key":"pone.0281135.ref045","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.rehab.2015.12.003","article-title":"Imaging for osteoarthritis","volume":"59","author":"D Hayashi","year":"2016","journal-title":"Ann Phys Rehabil Med"},{"issue":"4","key":"pone.0281135.ref046","doi-asserted-by":"crossref","first-page":"414.e7","DOI":"10.1016\/j.crad.2017.11.008","article-title":"18F-NaF PET\/CT for the evaluation of temporomandibular joint disorder","volume":"73","author":"MS Suh","year":"2018","journal-title":"Clin Radiol. avr"},{"issue":"12","key":"pone.0281135.ref047","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1007\/s00296-010-1520-4","article-title":"Evaluation of osteoarthritis induced by treadmill-running exercise using the modified Mankin and the new OARSI assessment system","volume":"31","author":"YJ Lee","year":"2011","journal-title":"Rheumatol Int. d\u00e9c"},{"issue":"1","key":"pone.0281135.ref048","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1002\/jor.1100100107","article-title":"The reliability of the Mankin score for osteoarthritis","volume":"10","author":"JA van der Sluijs","year":"1992","journal-title":"J Orthop Res"},{"key":"pone.0281135.ref049","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1038\/s41413-018-0027-6","article-title":"Aberrant activation of latent transforming growth factor-\u03b2 initiates the onset of temporomandibular joint osteoarthritis","volume":"6","author":"L Zheng","year":"2018","journal-title":"Bone Res"},{"key":"pone.0281135.ref050","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.archoralbio.2018.07.003","article-title":"Experimental model of temporomandibular joint arthritis: Evaluation of contralateral joint and masticatory muscles","volume":"95","author":"GA Lemos","year":"2018","journal-title":"Arch Oral Biol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0281135","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,31]],"date-time":"2023-01-31T13:27:07Z","timestamp":1675171627000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0281135"}},"subtitle":[],"editor":[{"given":"Martina","family":"Ferrillo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2023,1,31]]},"references-count":50,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,1,31]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0281135","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,31]]}}}