{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:02:02Z","timestamp":1787022122485,"version":"build-2736575974"},"reference-count":61,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2023,1,30]],"date-time":"2023-01-30T00:00:00Z","timestamp":1675036800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001349","name":"National Medical Research Council","doi-asserted-by":"publisher","award":["NMRC\/CSASI\/0010\/2017"],"award-info":[{"award-number":["NMRC\/CSASI\/0010\/2017"]}],"id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>This study aimed to examine sarcopenia prevalence using the Asian Working Group for Sarcopenia 2019 (AWGS) and the Foundation for the National Institutes of Health (FNIH) definitions, and their associations with important health conditions affecting midlife Singaporean women. Muscle mass and function were objectively assessed in 1201 healthy community-dwelling subjects aged 45\u201369 years under the Integrated Women\u2019s Health Program (IWHP). Dual-energy X-ray absorptiometry (DXA), handgrip strength and the Short Physical Performance Battery (SPPB) were measured, and the relationship between sarcopenia with hypertension, type 2 diabetes (T2DM), osteoporosis, depression\/anxiety, and urinary incontinence were examined using binary logistic regression models. Sarcopenia prevalence was 18.0% and 7.7% by the AWGS and FNIH criteria respectively. Osteoporosis (aOR: 1.74, 95% CI: 1.02, 2.94) and T2DM (aOR: 1.98, 95% CI: 1.14, 3.42) was positively associated with AWGS- and FNIH-defined sarcopenia respectively, while hypertension was not, after adjustment for age, ethnicity, education levels and menopausal status. A negative percent agreement of 95.6% suggests good agreement between the criteria in the absence of sarcopenia. Even though they represent a single concept, sarcopenia by either criterion differed in their relationships with diabetes and osteoporosis, suggesting the need for further rationalization of diagnostic criteria.<\/jats:p>","DOI":"10.1371\/journal.pone.0281144","type":"journal-article","created":{"date-parts":[[2023,1,30]],"date-time":"2023-01-30T14:46:36Z","timestamp":1675089996000},"page":"e0281144","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":8,"title":["Association of sarcopenia with important health conditions among community-dwelling Asian women"],"prefix":"10.1371","volume":"18","author":[{"given":"Beverly Wen-Xin","family":"Wong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Win Pa Pa","family":"Thu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiong Huak","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan Jane Sinclair","family":"Logan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane A.","family":"Cauley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6511-770X","authenticated-orcid":true,"given":"Eu-Leong","family":"Yong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2023,1,30]]},"reference":[{"issue":"1","key":"pone.0281144.ref001","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.clnu.2019.01.002","article-title":"Falls among older adults with sarcopenia dwelling in nursing home or community: A meta-analysis.","volume":"39","author":"X Zhang","year":"2020","journal-title":"Clin Nutr"},{"issue":"10191","key":"pone.0281144.ref002","doi-asserted-by":"crossref","first-page":"2636","DOI":"10.1016\/S0140-6736(19)31138-9","article-title":"Sarcopenia.","volume":"393","author":"AJ Cruz-Jentoft","year":"2019","journal-title":"Lancet"},{"issue":"9","key":"pone.0281144.ref003","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1038\/ejcn.2016.73","article-title":"Financial impact of sarcopenia on hospitalization costs.","volume":"70","author":"AS Sousa","year":"2016","journal-title":"Eur J Clin Nutr"},{"key":"pone.0281144.ref004","article-title":"Relationship Between Sarcopenia and Cardiovascular Diseases in the Elderly: An Overview.","volume":"8","author":"N He","year":"2021","journal-title":"Frontiers in Cardiovascular Medicine."},{"key":"pone.0281144.ref005","first-page":"1","article-title":"Sarcopenia Is Associated with Mortality in Adults: A Systematic Review and Meta-Analysis","author":"J Xu","year":"2021","journal-title":"Gerontology"},{"issue":"1","key":"pone.0281144.ref006","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1093\/ije\/dyl224","article-title":"Grip strength, body composition, and mortality.","volume":"36","author":"CR Gale","year":"2007","journal-title":"Int J Epidemiol"},{"issue":"4","key":"pone.0281144.ref007","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1093\/ageing\/afq034","article-title":"Sarcopenia: European consensus on definition and diagnosis: Report of the European Working Group on Sarcopenia in Older People.","volume":"39","author":"AJ Cruz-Jentoft","year":"2010","journal-title":"Age Ageing."},{"issue":"4","key":"pone.0281144.ref008","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1093\/ageing\/afz046","article-title":"Sarcopenia: revised European consensus on definition and diagnosis.","volume":"48","author":"AJ Cruz-Jentoft","year":"2019","journal-title":"Age Ageing"},{"issue":"3","key":"pone.0281144.ref009","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.jamda.2019.12.012","article-title":"Asian Working Group for Sarcopenia: 2019 Consensus Update on Sarcopenia Diagnosis and Treatment.","volume":"21","author":"LK Chen","year":"2020","journal-title":"J Am Med Dir Assoc."},{"issue":"5","key":"pone.0281144.ref010","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1093\/gerona\/glu023","article-title":"Cutpoints for low appendicular lean mass that identify older adults with clinically significant weakness","volume":"69","author":"PM Cawthon","year":"2014","journal-title":"J Gerontol A Biol Sci Med Sci"},{"issue":"5","key":"pone.0281144.ref011","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1093\/gerona\/glu012","article-title":"Criteria for clinically relevant weakness and low lean mass and their longitudinal association with incident mobility impairment and mortality: the foundation for the National Institutes of Health (FNIH) sarcopenia project.","volume":"69","author":"RR McLean","year":"2014","journal-title":"J Gerontol A Biol Sci Med Sci"},{"issue":"4","key":"pone.0281144.ref012","doi-asserted-by":"crossref","first-page":"885 e1","DOI":"10.1016\/j.jamda.2020.05.029","article-title":"Prevalence and Associated Factors of Sarcopenia in Singaporean Adults-The Yishun Study.","volume":"22","author":"BWJ Pang","year":"2021","journal-title":"J Am Med Dir Assoc."},{"issue":"6","key":"pone.0281144.ref013","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1007\/s12603-020-1371-y","article-title":"Muscle Strength Definitions Matter: Prevalence of Sarcopenia and Predictive Validity for Adverse Outcomes Using the European Working Group on Sarcopenia in Older People 2 (EWGSOP2) Criteria.","volume":"24","author":"J Chew","year":"2020","journal-title":"J Nutr Health Aging"},{"issue":"12","key":"pone.0281144.ref014","doi-asserted-by":"crossref","first-page":"2568","DOI":"10.1111\/jgs.16132","article-title":"Associations between Skeletal Muscle and Myocardium in Aging: A Syndrome of \"Cardio-Sarcopenia\"?","volume":"67","author":"BMH Keng","year":"2019","journal-title":"J Am Geriatr Soc"},{"issue":"1","key":"pone.0281144.ref015","doi-asserted-by":"crossref","first-page":"2956","DOI":"10.1038\/s41598-020-59914-3","article-title":"Association between Lower Extremity Skeletal Muscle Mass and Impaired Cognitive Function in Type 2 Diabetes.","volume":"10","author":"S Low","year":"2020","journal-title":"Sci Rep"},{"issue":"3","key":"pone.0281144.ref016","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1017\/S2040174410000097","article-title":"The developmental origins of sarcopenia: from epidemiological evidence to underlying mechanisms","volume":"1","author":"A Sayer","year":"2010","journal-title":"Journal of developmental origins of health and disease"},{"issue":"1","key":"pone.0281144.ref017","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1002\/jcsm.12651","article-title":"Sarcopenia: prevalence, associated factors, and the risk of mortality and disability in Japanese older adults.","volume":"12","author":"A Kitamura","year":"2021","journal-title":"J Cachexia Sarcopenia Muscle"},{"issue":"4","key":"pone.0281144.ref018","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.maturitas.2011.01.014","article-title":"Menopause and sarcopenia: A potential role for sex hormones.","volume":"68","author":"V Messier","year":"2011","journal-title":"Maturitas"},{"issue":"4","key":"pone.0281144.ref019","first-page":"186","article-title":"Changes in muscle mass and strength after menopause.","volume":"9","author":"ML Maltais","year":"2009","journal-title":"J Musculoskelet Neuronal Interact"},{"key":"pone.0281144.ref020","article-title":"Blood pressure and adiposity in midlife Singaporean women","author":"WPP Thu","year":"2021","journal-title":"Hypertens Res"},{"key":"pone.0281144.ref021","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.maturitas.2020.04.003","article-title":"Risk factors for insulin resistance in midlife Singaporean women.","volume":"137","author":"I Sundstrom-Poromaa","year":"2020","journal-title":"Maturitas"},{"issue":"9","key":"pone.0281144.ref022","doi-asserted-by":"crossref","first-page":"2633","DOI":"10.1007\/s00198-017-4095-z","article-title":"Chronic joint pain and handgrip strength correlates with osteoporosis in mid-life women: a Singaporean cohort","volume":"28","author":"S Logan","year":"2017","journal-title":"Osteoporos Int"},{"issue":"9","key":"pone.0281144.ref023","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1097\/GME.0000000000001355","article-title":"Objective measures of physical performance associated with depression and\/or anxiety in midlife Singaporean women.","volume":"26","author":"S Ganasarajah","year":"2019","journal-title":"Menopause"},{"issue":"9","key":"pone.0281144.ref024","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1007\/s00192-019-04132-3","article-title":"Risk factors and prevalence of urinary incontinence in mid-life Singaporean women: the Integrated Women\u2019s Health Program.","volume":"31","author":"KL Ng","year":"2020","journal-title":"Int Urogynecol J"},{"issue":"2","key":"pone.0281144.ref025","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1093\/ije\/dyx278","article-title":"Cohort Profile: The Integrated Women\u2019s Health Programme (IWHP): a study of key health issues of midlife Singaporean women.","volume":"47","author":"WPP Thu","year":"2018","journal-title":"Int J Epidemiol"},{"issue":"8","key":"pone.0281144.ref026","doi-asserted-by":"crossref","first-page":"573","DOI":"10.7326\/0003-4819-147-8-200710160-00010","article-title":"The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies.","volume":"147","author":"E von Elm","year":"2007","journal-title":"Ann Intern Med"},{"issue":"6","key":"pone.0281144.ref027","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1007\/BF01622200","article-title":"Assessment of fracture risk and its application to screening for postmenopausal osteoporosis: synopsis of a WHO report.","volume":"4","author":"JA Kanis","year":"1994","journal-title":"WHO Study Group. Osteoporos Int"},{"issue":"3","key":"pone.0281144.ref028","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1177\/014662167700100306","article-title":"The CES-D scale: A self-report depression scale for research in the general population.","volume":"1","author":"LS Radloff","year":"1977","journal-title":"Applied psychological measurement"},{"issue":"10","key":"pone.0281144.ref029","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1001\/archinte.166.10.1092","article-title":"A brief measure for assessing generalized anxiety disorder: the GAD-7","volume":"166","author":"RL Spitzer","year":"2006","journal-title":"Arch Intern Med"},{"issue":"1","key":"pone.0281144.ref030","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.ajog.2004.12.025","article-title":"Short forms of two condition-specific quality-of-life questionnaires for women with pelvic floor disorders (PFDI-20 and PFIQ-7).","volume":"193","author":"MD Barber","year":"2005","journal-title":"Am J Obstet Gynecol"},{"issue":"2","key":"pone.0281144.ref031","doi-asserted-by":"crossref","first-page":"M85","DOI":"10.1093\/geronj\/49.2.M85","article-title":"A short physical performance battery assessing lower extremity function: association with self-reported disability and prediction of mortality and nursing home admission","volume":"49","author":"JM Guralnik","year":"1994","journal-title":"J Gerontol"},{"issue":"5","key":"pone.0281144.ref032","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1093\/gerona\/glu010","article-title":"The FNIH sarcopenia project: rationale, study description, conference recommendations, and final estimates","volume":"69","author":"SA Studenski","year":"2014","journal-title":"J Gerontol A Biol Sci Med Sci"},{"issue":"6","key":"pone.0281144.ref033","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1123\/jpah.6.6.790","article-title":"Global physical activity questionnaire (GPAQ): nine country reliability and validity study.","volume":"6","author":"FC Bull","year":"2009","journal-title":"J Phys Act Health"},{"issue":"1","key":"pone.0281144.ref034","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1007\/s11657-021-00880-2","article-title":"Predictors of circulating vitamin D levels in healthy mid-life Singaporean women.","volume":"16","author":"WF Cheong","year":"2021","journal-title":"Arch Osteoporos"},{"issue":"2","key":"pone.0281144.ref035","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.annepidem.2007.12.001","article-title":"Vitamin D status: measurement, interpretation, and clinical application.","volume":"19","author":"MF Holick","year":"2009","journal-title":"Ann Epidemiol"},{"issue":"5","key":"pone.0281144.ref036","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1093\/gerona\/glu013","article-title":"An evidence-based comparison of operational criteria for the presence of sarcopenia.","volume":"69","author":"T-T Dam","year":"2014","journal-title":"Journals of Gerontology Series A: Biomedical Sciences and Medical Sciences."},{"key":"pone.0281144.ref037","article-title":"Encyclopedia of biostatistics: J.","author":"P Armitage","year":"1998","journal-title":"Wiley"},{"issue":"5","key":"pone.0281144.ref038","doi-asserted-by":"crossref","first-page":"932","DOI":"10.2337\/dc08-1856","article-title":"Relation of abdominal fat depots to systemic markers of inflammation in type 2 diabetes","volume":"32","author":"S Sam","year":"2009","journal-title":"Diabetes Care"},{"key":"pone.0281144.ref039","first-page":"1041186","article-title":"Changes of sarcopenia case finding by different Asian Working Group for Sarcopenia in community indwelling middle-aged and old people.","volume":"9","author":"CH Ko","year":"2022","journal-title":"Front Med (Lausanne)."},{"issue":"6","key":"pone.0281144.ref040","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/j.jamda.2020.03.018","article-title":"Sarcopenia in Korean Community-Dwelling Adults Aged 70 Years and Older: Application of Screening and Diagnostic Tools From the Asian Working Group for Sarcopenia 2019 Update.","volume":"21","author":"M Kim","year":"2020","journal-title":"J Am Med Dir Assoc."},{"issue":"12","key":"pone.0281144.ref041","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/j.puhe.2007.04.009","article-title":"The effect of season and weather on physical activity: a systematic review.","volume":"121","author":"P Tucker","year":"2007","journal-title":"Public Health"},{"issue":"Suppl 1","key":"pone.0281144.ref042","first-page":"8","article-title":"Health effects of active commuting to work: The available evidence before GISMO. Scand J Med Sci","volume":"1","author":"C Schafer","year":"2020","journal-title":"Sports"},{"issue":"4","key":"pone.0281144.ref043","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1159\/000513247","article-title":"The Comparison of Sarcopenia Diagnostic Criteria using AWGS 2019 with the Other Five Criteria in West China","volume":"67","author":"X Liu","year":"2021","journal-title":"Gerontology"},{"key":"pone.0281144.ref044","doi-asserted-by":"crossref","first-page":"110798","DOI":"10.1016\/j.exger.2019.110798","article-title":"Comparison of revised EWGSOP criteria and four other diagnostic criteria of sarcopenia in Chinese community-dwelling elderly residents","volume":"130","author":"L Yang","year":"2020","journal-title":"Exp Gerontol"},{"issue":"4","key":"pone.0281144.ref045","doi-asserted-by":"crossref","first-page":"465","DOI":"10.2337\/diacare.23.4.465","article-title":"Visceral adiposity and risk of type 2 diabetes: a prospective study among Japanese Americans","volume":"23","author":"EJ Boyko","year":"2000","journal-title":"Diabetes Care"},{"issue":"4","key":"pone.0281144.ref046","doi-asserted-by":"crossref","first-page":"643","DOI":"10.3904\/kjim.2016.015","article-title":"Differences among skeletal muscle mass indices derived from height-, weight-, and body mass index-adjusted models in assessing sarcopenia","volume":"31","author":"KM Kim","year":"2016","journal-title":"Korean J Intern Med"},{"issue":"1","key":"pone.0281144.ref047","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1186\/s12877-020-01672-y","article-title":"Sarcopenia is associated with hypertension in older adults: a systematic review and meta-analysis","volume":"20","author":"T Bai","year":"2020","journal-title":"BMC Geriatr"},{"issue":"1","key":"pone.0281144.ref048","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1210\/jc.2013-3190","article-title":"Association between lean mass, fat mass, and bone mineral density: a meta-analysis","volume":"99","author":"LT Ho-Pham","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"pone.0281144.ref049","doi-asserted-by":"crossref","first-page":"37","DOI":"10.4082\/kjfm.2016.37.1.37","article-title":"Sarcopenia Is Not Associated with Depression in Korean Adults: Results from the 2010\u20132011 Korean National Health and Nutrition Examination Survey.","volume":"37","author":"CH Byeon","year":"2016","journal-title":"Korean J Fam Med."},{"issue":"5","key":"pone.0281144.ref050","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1093\/ageing\/afx094","article-title":"Is sarcopenia associated with depression? A systematic review and meta-analysis of observational studies","volume":"46","author":"KV Chang","year":"2017","journal-title":"Age Ageing"},{"issue":"6","key":"pone.0281144.ref051","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1007\/s41999-019-00232-x","article-title":"The relationship between sarcopenia and urinary incontinence.","volume":"10","author":"T Erdogan","year":"2019","journal-title":"Eur Geriatr Med"},{"key":"pone.0281144.ref052","doi-asserted-by":"crossref","first-page":"835","DOI":"10.2147\/CIA.S132940","article-title":"Relationship between sarcopenia and physical activity in older people: a systematic review and meta-analysis.","volume":"12","author":"M Steffl","year":"2017","journal-title":"Clinical interventions in aging"},{"key":"pone.0281144.ref053","unstructured":"National Population Health Survey 2020: Epidemiology & Disease Control Division and Policy, Research & Surveillance Group. Ministry of Health and Health Promotion Board, Singapore; [Available from: https:\/\/www.moh.gov.sg\/docs\/librariesprovider5\/default-document-library\/nphs-2020-survey-report.pdf."},{"key":"pone.0281144.ref054","unstructured":"National Health Survey 2010 Epidemiology & Disease Control Division. Ministry of Health and Health Promotion Board, Singapore; [Available from: https:\/\/www.moh.gov.sg\/docs\/librariesprovider5\/resources-statistics\/reports\/nhs2010\u2014low-res.pdf."},{"key":"pone.0281144.ref055","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejim.2021.06.003","article-title":"Sarcopenia measurement in research and clinical practice","volume":"90","author":"E Dent","year":"2021","journal-title":"Eur J Intern Med"},{"issue":"5","key":"pone.0281144.ref056","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1093\/gerona\/glu011","article-title":"Grip strength cutpoints for the identification of clinically relevant weakness","volume":"69","author":"DE Alley","year":"2014","journal-title":"J Gerontol A Biol Sci Med Sci"},{"issue":"9","key":"pone.0281144.ref057","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1093\/gerona\/glab020","article-title":"The Association of Muscle Mass Measured by D3-Creatine Dilution Method With Dual-Energy X-Ray Absorptiometry and Physical Function in Postmenopausal Women","volume":"76","author":"K Zhu","year":"2021","journal-title":"J Gerontol A Biol Sci Med Sci"},{"issue":"6","key":"pone.0281144.ref058","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1002\/jcsm.12834","article-title":"Adverse muscle composition predicts all-cause mortality in the UK Biobank imaging study.","volume":"12","author":"J Linge","year":"2021","journal-title":"J Cachexia Sarcopenia Muscle"},{"issue":"6","key":"pone.0281144.ref059","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1007\/s12603-020-1381-9","article-title":"Ethnic Groups Differences in the Prevalence of Sarcopenia Using the AWGS Criteria","volume":"24","author":"X Liu","year":"2020","journal-title":"J Nutr Health Aging"},{"issue":"6","key":"pone.0281144.ref060","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1093\/gerona\/glx148","article-title":"FNIH-defined Sarcopenia Predicts Adverse Outcomes Among Community-Dwelling Older People in Taiwan: Results From I-Lan Longitudinal Aging Study","volume":"73","author":"T-C Tang","year":"2017","journal-title":"The Journals of Gerontology: Series A"},{"key":"pone.0281144.ref061","unstructured":"Department of Statistics, Singapore. General Household Survey (GHS) 2015 [Available from: https:\/\/www.singstat.gov.sg\/publications\/ghs\/ghs2015content."}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0281144","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,30]],"date-time":"2023-01-30T14:47:17Z","timestamp":1675090037000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0281144"}},"subtitle":[],"editor":[{"given":"Kyung-Wan","family":"Baek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2023,1,30]]},"references-count":61,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,1,30]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0281144","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,30]]}}}