{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T18:37:21Z","timestamp":1778265441329,"version":"3.51.4"},"reference-count":39,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2023,8,2]],"date-time":"2023-08-02T00:00:00Z","timestamp":1690934400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"\n Background<\/jats:title>\n \n Oxygen therapy is used in various clinical situation, but its clinical outcomes are inconsistent. The relationship between the fraction of inspired oxygen (F\n I<\/jats:sub>\n O\n 2<\/jats:sub>\n ) during transcatheter aortic valve implantation (TAVI) and clinical outcomes has not been well studied. We investigated the association of F\n I<\/jats:sub>\n O\n 2<\/jats:sub>\n (low vs. high) and myocardial injury in patients undergoing TAVI.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Adults undergoing transfemoral TAVI under general anesthesia were randomly assigned to receive F\n I<\/jats:sub>\n O\n 2<\/jats:sub>\n 0.3 or 0.8 during procedure. The primary outcome was the area under the curve (AUC) for high-sensitivity cardiac troponin I (hs-cTnI) during the first 72 h following TAVI. Secondary outcomes included the AUC for postprocedural creatine kinase-myocardial band (CK-MB), acute kidney injury and recovery, conduction abnormalities, pacemaker implantation, stroke, myocardial infarction, and in-hospital mortality.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Between October 2017 and April 2022, 72 patients were randomized and 62 were included in the final analysis (n = 31 per group). The median (IQR) AUC for hs-cTnI in the first 72 h was 42.66 (24.82\u201365.44) and 71.96 (35.38\u2013116.34) h\u00b7ng\/mL in the F\n I<\/jats:sub>\n O\n 2<\/jats:sub>\n 0.3 and 0.8 groups, respectively (p = 0.066). The AUC for CK-MB in the first 72 h was 257.6 (155.6\u2013322.0) and 342.2 (195.4\u2013485.2) h\u00b7ng\/mL in the F\n I<\/jats:sub>\n O\n 2<\/jats:sub>\n 0.3 and 0.8 groups, respectively (p = 0.132). Acute kidney recovery, defined as an increase in the estimated glomerular filtration rate \u2265 25% of baseline in 48 h, was more common in the F\n I<\/jats:sub>\n O\n 2<\/jats:sub>\n 0.3 group (65% vs. 39%, p = 0.042). Other clinical outcomes were comparable between the groups.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n The F\n I<\/jats:sub>\n O\n 2<\/jats:sub>\n level did not have a significant effect on periprocedural myocardial injury following TAVI. However, considering the marginal results, a benefit of low F\n I<\/jats:sub>\n O\n 2<\/jats:sub>\n during TAVI could not be ruled out.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1371\/journal.pone.0281232","type":"journal-article","created":{"date-parts":[[2023,8,2]],"date-time":"2023-08-02T13:39:28Z","timestamp":1690983568000},"page":"e0281232","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effects of low versus high inspired oxygen fraction on myocardial injury after transcatheter aortic valve implantation: A randomized clinical trial"],"prefix":"10.1371","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6478-8616","authenticated-orcid":true,"given":"Youn Joung","family":"Cho","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7477-8438","authenticated-orcid":true,"given":"Cheun","family":"Hyeon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karam","family":"Nam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seohee","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae-Woo","family":"Ju","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeehoon","family":"Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung-Kyu","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyo-Soo","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8686-1124","authenticated-orcid":true,"given":"Yunseok","family":"Jeon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2023,8,2]]},"reference":[{"key":"pone.0281232.ref001","doi-asserted-by":"crossref","first-page":"e288","DOI":"10.1016\/S1473-3099(16)30402-9","article-title":"New 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Surgical Aortic Valve Replacement (from the Northern New England Cardiovascular Disease Study Group).","volume":"125","author":"R Lahoud","year":"2020","journal-title":"Am J Cardiol"},{"key":"pone.0281232.ref038","doi-asserted-by":"crossref","first-page":"e0255806","DOI":"10.1371\/journal.pone.0255806","article-title":"Acute kidney injury and acute kidney recovery following Transcatheter Aortic Valve Replacement.","volume":"16","author":"M Peillex","year":"2021","journal-title":"PLoS One"},{"key":"pone.0281232.ref039","doi-asserted-by":"crossref","first-page":"E436","DOI":"10.1002\/ccd.29496","article-title":"Comparing outcomes of general anesthesia and monitored anesthesia care during transcatheter aortic valve replacement: The Cleveland Clinic Foundation experience.","volume":"98","author":"Y Sammour","year":"2021","journal-title":"Catheter Cardiovasc Interv"}],"container-title":["PLOS 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