{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T10:43:52Z","timestamp":1756896232482,"version":"3.40.5"},"reference-count":31,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T00:00:00Z","timestamp":1675296000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>Creatine kinase (CK) has been associated with insulin resistance and identified as a risk marker of cardiovascular disease largely by its relationship with hypertension and increased body mass index. This study determined whether CK is a predictor of glycated haemoglobin (HbA<jats:sub>1C<\/jats:sub>) in a nondiabetic general population.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>Associations between CK and the outcome variable HbA<jats:sub>1C<\/jats:sub> (%) were performed by variance and multivariate analyses in 11662 nondiabetic subjects defined as HbA<jats:sub>1C<\/jats:sub> (%) &lt;6.5 who participated in the population based Troms\u00f8 study (Troms\u00f8 6) in Norway.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>Abnormal elevated CK was detected in 543\/11662 participants (4.66%). Mean HbA<jats:sub>1C<\/jats:sub> (%) in the \u201chigh CK\u201d group was 5.62 (SD = 0.33) compared to 5.52 (SD = 0.36) in the \u201cnormal CK\u201d group, <jats:italic>P<\/jats:italic> &lt;0.001. CK increased significantly and linearly with higher levels of HbA<jats:sub>1C<\/jats:sub> (%) quartiles in women (<jats:italic>P<\/jats:italic> &lt;0.001) and non-linearly in men (<jats:italic>P<\/jats:italic> &lt;0.001). In a multivariate analysis, CK was independently associated with HbA<jats:sub>1C<\/jats:sub> (%) after adjusting for age, sex, body mass index, blood pressure, glucose, lipids, C-reactive protein, creatinine, alanine transaminase and aspartate aminotransferase. A 1-unit increase in log CK was associated with a 0.17-unit increase in HbA<jats:sub>1C<\/jats:sub> (%).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>These data demonstrate a positive and independent association between CK and glycated haemoglobin in a nondiabetic general population.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0281239","type":"journal-article","created":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T18:37:17Z","timestamp":1675363037000},"page":"e0281239","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":3,"title":["Creatine kinase is associated with glycated haemoglobin in a nondiabetic population. 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