{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T21:15:18Z","timestamp":1762377318045,"version":"3.37.3"},"reference-count":29,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2023,2,8]],"date-time":"2023-02-08T00:00:00Z","timestamp":1675814400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100018583","name":"Wuhan Science and Technology Project","doi-asserted-by":"publisher","award":["2013062301010820"],"award-info":[{"award-number":["2013062301010820"]}],"id":[{"id":"10.13039\/501100018583","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\"><jats:title>Background<\/jats:title><jats:p>Chinese idioms have potential to act as preliminary training material in studies on post-stroke aphasia.<\/jats:p><\/jats:sec><jats:sec id=\"sec002\"><jats:title>Objective<\/jats:title><jats:p>To explore an extension speech training program that takes Chinese idioms as context and expands them into characters, words, sentences and paragraphs and evaluate the effects of this program in patients with post-stroke non-fluent aphasia.<\/jats:p><\/jats:sec><jats:sec id=\"sec003\"><jats:title>Methods<\/jats:title><jats:p>This was a randomized controlled trial. We recruited patients with post-stroke non-fluent aphasia from the Renmin Hospital of Wuhan University from January 2021 to January 2022. Participants were randomly assigned to group I and group II. Patients in group I had treatment with extension speech training based on Chinese idioms, and those in group II had treatment with conventional speech rehabilitation training. The training period in both groups was 40 min daily for 2 weeks.<\/jats:p><\/jats:sec><jats:sec id=\"sec004\"><jats:title>Results<\/jats:title><jats:p>A total of 70 patients (group I, n = 34; and group II, n = 36) completed the trial and were analyzed according to protocol. There were no significant differences in baseline values between both groups. After intervention, the scores of oral expression, comprehension, and reading in the Aphasia Battery Of Chinese scale and the scores of the Comprehensive Activities of Daily Living questionnaire significantly improved in both groups (P &lt;0.05), with group I benefiting more (P &lt;0.05).<\/jats:p><\/jats:sec><jats:sec id=\"sec005\"><jats:title>Conclusion<\/jats:title><jats:p>This extension speech training program based on Chinese idioms can improve the language function and daily communication ability of the patients with post-stroke non-fluent aphasia.<\/jats:p><\/jats:sec><jats:sec id=\"sec006\"><jats:title>Trial registration<\/jats:title><jats:p>Chinese Clinical Trial Registry<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.chictr.org.cn\/showproj.aspx?proj=52113\" xlink:type=\"simple\">ChiCTR2000031825<\/jats:ext-link>.<\/jats:p><\/jats:sec>","DOI":"10.1371\/journal.pone.0281335","type":"journal-article","created":{"date-parts":[[2023,2,8]],"date-time":"2023-02-08T18:30:47Z","timestamp":1675881047000},"page":"e0281335","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effect of an extension speech training program based on Chinese idioms in patients with post-stroke non-fluent aphasia: A randomized controlled 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Johnson","year":"2019","journal-title":"Am J Speech Lang Pathol"},{"issue":"1","key":"pone.0281335.ref011","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/s41582-019-0282-1","article-title":"The neural and neurocomputational bases of recovery from post-stroke aphasia.","volume":"16","author":"JD Stefaniak","year":"2020","journal-title":"Nat Rev Neurol"},{"volume-title":"Aphasia.","year":"2021","author":"H Le","key":"pone.0281335.ref012"},{"key":"pone.0281335.ref013","first-page":"745","article-title":"Primary Progressive Aphasia and Stroke Aphasia.","volume":"24","author":"M Grossman","year":"2018","journal-title":"Continuum (Minneap Minn)."},{"issue":"3","key":"pone.0281335.ref014","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1161\/STROKEAHA.121.035216","article-title":"Dosage, Intensity, and Frequency of Language Therapy for Aphasia: A Systematic Review-Based, Individual Participant Data Network Meta-Analysis","volume":"53","author":"REhabilitation and 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