{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T22:27:39Z","timestamp":1769552859685,"version":"3.49.0"},"reference-count":57,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2023,2,15]],"date-time":"2023-02-15T00:00:00Z","timestamp":1676419200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"crossref","award":["711905"],"award-info":[{"award-number":["711905"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100007228","name":"Universidad Aut\u00f3noma de Baja California","doi-asserted-by":"publisher","award":["0239"],"award-info":[{"award-number":["0239"]}],"id":[{"id":"10.13039\/501100007228","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>Specific phobias are a common anxiety disorder that deteriorates the lives of people who suffer from them. To reduce the symptoms produced by this mental disorder exposure therapies have been used. However, low- and middle-income countries, including Mexico, have the lowest rate of treatment due to multiple barriers that prevent addressing mental health problems. Self-applied treatments have been explored in previous studies, nevertheless, high dropout rates are a common problem in this kind of treatment. An alternative is using immersive self-applied treatments that could help increase adherence to the treatment. This article aims to present a study protocol to explore the feasibility of an Internet self-applied exposure treatment for rat phobias, using four types of immersive multimedia elements: images, videos, video games, and 360\u00b0 videos. Also, the satisfaction and perception of a Virtual Therapy Assistant (VTA) that provides information and support to the user are described. The study protocol will compare two groups of participants, one on the waiting list, and the other will receive the self-applied treatment for rat phobia supported by the VTA. For this study, 45 participants will be recruited and the evaluation measures will be taken at four different times: baseline, post-treatment, and follow-ups at 3 and 6 months. The levels of anxiety and avoidance of the user manifested during the exposure to the multimedia elements, the improvement of the user\u2019s clinical symptoms, the level of satisfaction, the perception of effectiveness, and ease of use of the self-applied system will be evaluated. This study is expected to support the viability of self-applied treatment for rat phobias and the use of a VTA, showing the impact on treatment adherence. To the best of our knowledge, this is the first study to explore an exposure treatment for rats using different multimedia elements with the support of a VTA. The work will serve as a basis for the development of new virtual assistants that help in the treatment of other types of specific phobias. This research has been registered in Clinical Trials NCT (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT05081323\" xlink:type=\"simple\">NCT05081323<\/jats:ext-link>).<\/jats:p>","DOI":"10.1371\/journal.pone.0281338","type":"journal-article","created":{"date-parts":[[2023,2,15]],"date-time":"2023-02-15T18:34:50Z","timestamp":1676486090000},"page":"e0281338","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":3,"title":["An internet-based self-applied rat phobia treatment using a Virtual Therapy Assistant: Study protocol for a randomized controlled trial"],"prefix":"10.1371","volume":"18","author":[{"given":"Sonia 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In: Extended Abstracts of the 2019 CHI Conference on Human Factors in Computing Systems. CHI EA\u201919. New York, NY, USA: Association for Computing Machinery; 2019. p. 1\u20136. Available from: https:\/\/doi.org\/10.1145\/3290607.3313072.","DOI":"10.1145\/3290607.3313072"},{"key":"pone.0281338.ref017","doi-asserted-by":"crossref","first-page":"680","DOI":"10.3389\/fphar.2019.00680","article-title":"Development of a Complex Intervention to Improve Adherence to Antidiabetic Medication in Older People Using an Anthropomorphic Virtual Assistant Software","volume":"10","author":"I F\u00e9lix","year":"2019","journal-title":"Frontiers in Pharmacology"},{"key":"pone.0281338.ref018","doi-asserted-by":"crossref","unstructured":"Tiong EYC, Powers DMW, Maeder AJ. Dementia Virtual Assistant as Trainer and Therapist: Identifying Significant Memories and Interventions of Dementia Patients. In: Proceedings of the Australasian Computer Science Week Multiconference. ACSW\u201918. New York, NY, USA: Association for Computing Machinery; 2018. p. 1\u20139. Available from: https:\/\/doi.org\/10.1145\/3167918.3167953.","DOI":"10.1145\/3167918.3167953"},{"key":"pone.0281338.ref019","doi-asserted-by":"crossref","unstructured":"Wang J, Yang H, Shao R, Abdullah S, Sundar SS. Alexa as Coach: Leveraging Smart Speakers to Build Social Agents That Reduce Public Speaking Anxiety. In: Proceedings of the 2020 CHI Conference on Human Factors in Computing Systems. CHI\u201920. New York, NY, USA: Association for Computing Machinery; 2020. p. 1\u2013\u201313. Available from: https:\/\/doi.org\/10.1145\/3313831.3376561.","DOI":"10.1145\/3313831.3376561"},{"key":"pone.0281338.ref020","unstructured":"Bados L\u00f3pez A. Fobias espec\u00edficas: Naturaleza, evaluaci\u00f3n y tratamiento (2017); 2017."},{"key":"pone.0281338.ref021","doi-asserted-by":"crossref","unstructured":"Ramirez-Fernandez C, Mor\u00e1n AL, Garc\u00eda-Canseco E, Meza-Kubo V, Barreras E, Valenzuela O, et al. 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Available from: https:\/\/doi.org\/10.1037\/tms0000006.","DOI":"10.1037\/tms0000006"},{"key":"pone.0281338.ref024","unstructured":"Phase Locked Software. Study Randomizer [Software Application]; 2017. Available from: https:\/\/www.studyrandomizer.com."},{"issue":"2","key":"pone.0281338.ref025","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.brat.2012.10.007","article-title":"Effect of multiple context exposure on renewal in spider phobia","volume":"51","author":"Y Shiban","year":"2013","journal-title":"Behaviour Research and Therapy"},{"issue":"2","key":"pone.0281338.ref026","doi-asserted-by":"crossref","first-page":"175","DOI":"10.3758\/BF03193146","article-title":"G* Power 3: A flexible statistical power analysis program for the social, behavioral, and biomedical sciences","volume":"39","author":"F Faul","year":"2007","journal-title":"Behavior research methods"},{"issue":"1","key":"pone.0281338.ref027","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1037\/ccp0000459","article-title":"Attrition and adherence in smartphone-delivered interventions for mental health problems: A systematic and meta-analytic review","volume":"88","author":"J Linardon","year":"2020","journal-title":"Journal of consulting and clinical psychology"},{"key":"pone.0281338.ref028","doi-asserted-by":"crossref","unstructured":"Guill\u00e9n V, Fonseca-Baeza S, de Felipe IF, Botella C, Ba\u00f1os R, Garc\u00eda-Palacios A, et al. Effectiveness of family connections intervention for family members of persons with personality disorders in two different formats: Online vs face-to-face; 2022.","DOI":"10.1016\/j.invent.2022.100532"},{"key":"pone.0281338.ref029","first-page":"1","article-title":"Design of smart objects of fear with a taxonomy of factors affecting the user experience of exposure therapy systems for small-animal phobias","author":"AL Mor\u00e1n","year":"2020","journal-title":"Journal of Ambient Intelligence and Humanized Computing"},{"key":"pone.0281338.ref030","unstructured":"Ruiz-Garc\u00eda A. Eficacia de un tratamiento de exposici\u00f3n progresiva multimedia para fobias espec\u00edficas: un estudio cl\u00ednico y experimental [Efficacy of a multimedia progressive exposure treatment for specific phobias: a clinical and experimental study] [Ph.D. thesis]. Universidad de M\u00e1laga. M\u00e1laga; 2017."},{"key":"pone.0281338.ref031","doi-asserted-by":"crossref","first-page":"116","DOI":"10.3389\/fpsyt.2020.00116","article-title":"Gamified, automated virtual reality exposure therapy for fear of spiders: a single-subject trial under simulated real-world conditions","volume":"11","author":"P Lindner","year":"2020","journal-title":"Frontiers in psychiatry"},{"key":"pone.0281338.ref032","doi-asserted-by":"crossref","first-page":"2116","DOI":"10.3389\/fpsyg.2017.02116","article-title":"A public database of immersive VR videos with corresponding ratings of arousal, valence, and correlations between head movements and self report measures","volume":"8","author":"BJ Li","year":"2017","journal-title":"Frontiers in psychology"},{"key":"pone.0281338.ref033","unstructured":"American Heart Association editorial staff. Target Heart Rates Chart; 2021. Online. Available from: https:\/\/www.heart.org\/en\/healthy-living\/fitness\/fitness-basics\/target-heart-rates."},{"key":"pone.0281338.ref034","unstructured":"American Heart Association editorial staff. Tachycardia: Fast Heart Rate; 2016. Online. Available from: https:\/\/www.heart.org\/en\/health-topics\/arrhythmia\/about-arrhythmia\/tachycardia--fast-heart-rate."},{"key":"pone.0281338.ref035","unstructured":"Baccino T, Bellino C, Colombi T. Mesure de l\u2019utilisabilit\u00e9 des Interfaces [Measurement of the usability of Interfaces]. CNRS-Editions; 2005. Available from: https:\/\/halshs.archives-ouvertes.fr\/halshs-00630769."},{"key":"pone.0281338.ref036","volume-title":"Anxiety disorders interview schedule adult version: Client interview schedule","author":"TA Brown","year":"1994"},{"issue":"1","key":"pone.0281338.ref037","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/0005-7916(94)00072-T","article-title":"Fear of Spiders Questionnaire","volume":"26","author":"J Szymanski","year":"1995","journal-title":"Journal of Behavior Therapy and Experimental Psychiatry"},{"key":"pone.0281338.ref038","doi-asserted-by":"crossref","first-page":"665","DOI":"10.2147\/PRBM.S256781","article-title":"Evaluation of the Effectiveness of One- and Multi-Session Exposure-Based Treatments in Reducing Biological and Psychological Responses to Rat Phobia Among Students","volume":"13","author":"C Hemyari","year":"2020","journal-title":"Psychology Research and Behavior Management"},{"issue":"3","key":"pone.0281338.ref039","article-title":"Spanish adaptation of the \u201cSpider Fear Questionnaire\u201d (FSQ): Validity, reliability, sensitivity to therapeutic change and factorial structure","volume":"26","author":"E Forcadell","year":"2018","journal-title":"Behavioral Psychology\/Psicologia Conductual"},{"key":"pone.0281338.ref040","unstructured":"Spielberger CD, D\u00edaz-Guerrero R. Idare: inventario de ansiedad: rasgo-estado. Editorial El Manual Moderno Mexico City, Mexico; 1975."},{"issue":"5","key":"pone.0281338.ref041","first-page":"491","article-title":"Validaci\u00f3n del Inventario de Ansiedad Rasgo-Estado en padres con un hijo en terapia intensiva [The State-Trait Anxiety Inventory for parents who have hospitalized children in an intensive care unit]","volume":"48","author":"KE Rojas-Carrasco","year":"2010","journal-title":"Revista M\u00e9dica del Instituto Mexicano del Seguro Social"},{"issue":"3","key":"pone.0281338.ref042","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/0005-7967(79)90041-X","article-title":"Brief standard self-rating for phobic patients","volume":"17","author":"IM Marks","year":"1979","journal-title":"Behaviour research and therapy"},{"issue":"6","key":"pone.0281338.ref043","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1109\/MCG.2005.143","article-title":"Using augmented reality to treat phobias","volume":"25","author":"MC Juan","year":"2005","journal-title":"IEEE Computer Graphics and Applications"},{"issue":"2","key":"pone.0281338.ref044","first-page":"155","article-title":"Avances en los tratamientos psicol\u00f3gicos: la utilizaci\u00f3n de las nuevas tecnolog\u00edas de la informaci\u00f3n y la comunicaci\u00f3n [Advances in psychological treatments: The use of new information and communication technologies]","volume":"40","author":"C Botella","year":"2009","journal-title":"Anuario de Psicolog\u00eda"},{"issue":"1","key":"pone.0281338.ref045","doi-asserted-by":"crossref","first-page":"3","DOI":"10.5195\/ijt.2016.6196","article-title":"Development of the telehealth usability questionnaire (TUQ)","volume":"8","author":"B Parmanto","year":"2016","journal-title":"International journal of telerehabilitation"},{"issue":"6","key":"pone.0281338.ref046","first-page":"649","article-title":"Validation of a Spanish questionnaire on telemedicine usability","volume":"80","author":"N Bibiloni","year":"2020","journal-title":"Medicina"},{"key":"pone.0281338.ref047","unstructured":"Guy W. ECDEU assessment manual for psychopharmacology. Rockville, MD: National Institute of Mental Health: US Department of Health, Education, and Welfare Publication (ADM); 1976."},{"key":"pone.0281338.ref048","volume-title":"Cengage Advantage Books","author":"D Howell","year":"2016"},{"key":"pone.0281338.ref049","volume-title":"Essentials of statistics for the behavioral sciences","author":"FJ Gravetter","year":"2021"},{"issue":"3","key":"pone.0281338.ref050","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1136\/ebmh.4.3.70","article-title":"Intention to treat analysis in clinical trials when there are missing data","volume":"4","author":"D Streiner","year":"2001","journal-title":"Evidence-based mental health"},{"issue":"2","key":"pone.0281338.ref051","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0376-8716(02)00111-4","article-title":"\u2018Intention-to-treat\u2019 meets \u2018missing data\u2019: implications of alternate strategies for analyzing clinical trials data","volume":"68","author":"C Nich","year":"2002","journal-title":"Drug and alcohol dependence"},{"issue":"7","key":"pone.0281338.ref052","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1001\/jamapsychiatry.2019.0219","article-title":"Effectiveness of Self-guided App-Based Virtual Reality Cognitive Behavior Therapy for Acrophobia: A Randomized Clinical Trial","volume":"76","author":"T Donker","year":"2019","journal-title":"JAMA Psychiatry"},{"issue":"2","key":"pone.0281338.ref053","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0148237","article-title":"In vivo versus augmented reality exposure in the treatment of small animal phobia: a randomized controlled trial","volume":"11","author":"C Botella","year":"2016","journal-title":"PloS one"},{"key":"pone.0281338.ref054","doi-asserted-by":"crossref","unstructured":"Cruz T, Br\u00e1s S, Soares SC, Fernandes JM. Monitoring physiology and behavior using Android in phobias. 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