{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T22:09:52Z","timestamp":1793052592629,"version":"4.5.0"},"reference-count":45,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2023,3,3]],"date-time":"2023-03-03T00:00:00Z","timestamp":1677801600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Institute of Health","award":["R01 HL144690"],"award-info":[{"award-number":["R01 HL144690"]}]},{"name":"Dr. Vincent Miscia Cardiovascular Research Fund","award":["IDeA-CTR"],"award-info":[{"award-number":["IDeA-CTR"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Introduction<\/jats:title>\n<jats:p>Coronary artery bypass graft surgery (CABG) is an intervention in patients with extensive obstructive coronary artery disease diagnosed with invasive coronary angiography. Here we present and test a novel application of non-invasive computational assessment of coronary hemodynamics before and after bypass grafting.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods and results<\/jats:title>\n<jats:p>We tested the computational CABG platform in n = 2 post-CABG patients. The computationally calculated fractional flow reserve showed high agreement with the angiography-based fractional flow reserve. Furthermore, we performed multiscale computational fluid dynamics simulations of pre- and post-CABG under simulated resting and hyperemic conditions in n = 2 patient-specific anatomies 3D reconstructed from coronary computed tomography angiography. We computationally created different degrees of stenosis in the left anterior descending artery, and we showed that increasing severity of native artery stenosis resulted in augmented flow through the graft and improvement of resting and hyperemic flow in the distal part of the grafted native artery.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Conclusions<\/jats:title>\n<jats:p>We presented a comprehensive patient-specific computational platform that can simulate the hemodynamic conditions before and after CABG and faithfully reproduce the hemodynamic effects of bypass grafting on the native coronary artery flow. Further clinical studies are warranted to validate this preliminary data.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0281423","type":"journal-article","created":{"date-parts":[[2023,3,3]],"date-time":"2023-03-03T18:22:56Z","timestamp":1677867776000},"page":"e0281423","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":13,"title":["Patient-specific computational simulation of coronary artery bypass grafting"],"prefix":"10.1371","volume":"18","author":[{"given":"Wei","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasios Nikolaos","family":"Panagopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charu Hasini","family":"Vasa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammadali","family":"Sharzehee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shijia","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saurabhi","family":"Samant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Usama M.","family":"Oguz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Behram","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdallah","family":"Naser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khaled M.","family":"Harmouch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghassan S.","family":"Kassab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleem","family":"Siddique","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8955-0081","authenticated-orcid":true,"given":"Yiannis S.","family":"Chatzizisis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2023,3,3]]},"reference":[{"issue":"16","key":"pone.0281423.ref001","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1161\/CIRCULATIONAHA.117.031182","article-title":"Role of Invasive Functional Assessment in Surgical Revascularization of Coronary Artery Disease","volume":"137","author":"B Baibhav","year":"2018","journal-title":"Circulation"},{"issue":"2","key":"pone.0281423.ref002","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.jacc.2021.09.005","article-title":"2021 ACC\/AHA\/SCAI Guideline for Coronary Artery Revascularization: Executive Summary: A Report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines","volume":"79","author":"JS Lawton","year":"2022","journal-title":"Journal of the American College of Cardiology"},{"issue":"11","key":"pone.0281423.ref003","doi-asserted-by":"crossref","first-page":"2149","DOI":"10.1016\/j.jacc.2004.08.064","article-title":"Long-term patency of saphenous vein and left internal mammary artery grafts after coronary artery bypass surgery","volume":"44","author":"S Goldman","year":"2004","journal-title":"Journal of the American College of Cardiology"},{"issue":"18","key":"pone.0281423.ref004","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1161\/CIRCULATIONAHA.117.027597","article-title":"Mechanisms, Consequences, and Prevention of Coronary Graft Failure","volume":"136","author":"M Gaudino","year":"2017","journal-title":"Circulation"},{"issue":"4","key":"pone.0281423.ref005","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/j.ejcts.2008.07.011","article-title":"Patency rate of the internal thoracic artery to the left anterior descending artery bypass is reduced by competitive flow from the concomitant saphenous vein graft in the left coronary artery","volume":"34","author":"M Kawamura","year":"2008","journal-title":"European journal of cardio-thoracic surgery: official journal of the European Association for Cardio-thoracic Surgery"},{"issue":"3","key":"pone.0281423.ref006","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1002\/ccd.29864","article-title":"Influence of fractional flow reserve on grafts patency: Systematic review and patient-level meta-analysis","volume":"99","author":"G. 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