{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T22:02:54Z","timestamp":1788559374371,"version":"build-2803163510"},"reference-count":19,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2023,2,7]],"date-time":"2023-02-07T00:00:00Z","timestamp":1675728000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>\n                    Intraoperative magnesium has the effect of reducing postoperative opiate requirement, pain, and agitation. However, its effect on postoperative sedation and delirium is unclear. This study investigated the effect of magnesium on the postoperative Richmond Agitation-Sedation Scale (RASS) score and delirium following endovascular repair of aortic aneurysm (EVAR). Sixty-three consecutive patients diagnosed with abdominal (45) and thoracic (18) aortic aneurysm who underwent EVAR under general anesthesia were eligible. Patients were allocated randomly to the magnesium group (infusion of 30 mg\u2022kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    magnesium in the first hour followed by 10 mg\u2022kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    h\n                    <jats:sup>\u22121<\/jats:sup>\n                    until the end of surgical procedure, targeting total 60 mg\u2022kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    ) or the control group (0.9% saline at the same volume and rate). The primary outcome was whether magnesium had an effect on RASS score of patients at postoperative ICU admission. Secondary outcomes were effects on RASS score, numerical rating scale (NRS) score, Confusion Assessment Method for the Intensive Care Unit (CAM-ICU) until 24 h after postoperative ICU transfer, and length of ICU stay. At postoperative ICU admission, magnesium had no significant effect on the RASS score (0[\u22120.5 to 0] vs 0[0 to 0]; P = 0.114), but at 1 h the NRS score was statistically different, 2[0 to 4] vs 4[0 to 5] (P = 0.0406). However, other data (RASS score, NRS score, CAM-ICU and length of ICU stay) did not show a significant difference. Our results did not show that intraoperative magnesium of target total 60 mg\u2022kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    affected postoperative RASS score for undergoing EVAR.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Trial registration:<\/jats:bold>\n                    The current study was registered according to WHO and ICMJE standards on 4 July 2018, under registration number the Japan Registry of Clinical Trials,\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.isrctn.com\/iRCTs041190013\" xlink:type=\"simple\">iRCTs041190013<\/jats:ext-link>\n                    .\n                  <\/jats:p>","DOI":"10.1371\/journal.pone.0281457","type":"journal-article","created":{"date-parts":[[2023,2,7]],"date-time":"2023-02-07T13:28:53Z","timestamp":1675776533000},"page":"e0281457","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":8,"title":["Effect of intraoperative systemic magnesium sulphate on postoperative Richmond Agitation-Sedation Scale score after endovascular repair of aortic aneurysm under general anesthesia: A double-blind, randomized, controlled trial"],"prefix":"10.1371","volume":"18","author":[{"given":"Haruna","family":"Kanamori","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6927-8287","authenticated-orcid":true,"given":"Yoshihito","family":"Fujita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rina","family":"Joko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryota","family":"Ishihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Fujiwara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2023,2,7]]},"reference":[{"key":"pone.0281457.ref001","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1097\/EJA.0000000000000594","article-title":"European Society of Anaesthesiology evidence-based and consensus-based guideline on postoperative delirium.","volume":"34","author":"C Aldecoa","year":"2017","journal-title":"Eur J Anaesthesiol"},{"key":"pone.0281457.ref002","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1016\/j.jvs.2017.04.077","article-title":"A systematic review and meta-analysis of factors for delirium in vascular surgical patients","volume":"66","author":"C Oldroyd","year":"2017","journal-title":"J Vasc Surg"},{"key":"pone.0281457.ref003","doi-asserted-by":"crossref","first-page":"i98","DOI":"10.1093\/bja\/aet055","article-title":"Monitoring depth of anaesthesia in a randomized trial decreases the rate of postoperative delirium but not postoperative cognitive dysfunction","volume":"1","author":"FM Radtke","year":"2013","journal-title":"Br J Anaesth"},{"issue":"Suppl 1","key":"pone.0281457.ref004","first-page":"S9","article-title":"Dexmedetomidine for prevention of postoperative delirium in older adults undergoing oesophagectomy with total intravenous anaesthesia A double-blind, randomised clinical trial.","volume":"38","author":"JZ Hu","year":"2021","journal-title":"Eur J Anaesthesiol"},{"key":"pone.0281457.ref005","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1093\/bja\/ael037","article-title":"Magnesium moderately decreases remifentanil dosage required for pain management after cardiac surgery","volume":"96","author":"B Steinlechner","year":"2006","journal-title":"Br J Anaesth"},{"key":"pone.0281457.ref006","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1093\/bja\/aew227","article-title":"Magnesium sulphate attenuates acute postoperative pain and increased pain intensity after surgical injury in staged bilateral total knee arthroplasty: a randomized, double-blinded, placebo-controlled trial","volume":"117","author":"HJ Shin","year":"2016","journal-title":"Br J Anaesth"},{"key":"pone.0281457.ref007","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1213\/ANE.0000000000001028","article-title":"The Effect of Systemic Magnesium on Postsurgical Pain in Children Undergoing Tonsillectomies: A Double-Blinded, Randomized, Placebo-Controlled Trial.","volume":"121","author":"HA Benzon","year":"2015","journal-title":"Anesth Analg"},{"key":"pone.0281457.ref008","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1097\/EJA.0000000000001164","article-title":"The effect of intravenous magnesium on postoperative morphine consumption in noncardiac surgery: A systematic review and meta-analysis with trial sequential analysis","volume":"37","author":"KT Ng","year":"2020","journal-title":"Eur J Anaesthesiol"},{"key":"pone.0281457.ref009","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1097\/EJA.0000000000000642","article-title":"Intraoperative magnesium sulphate decreases agitation and pain in patients undergoing functional endoscopic surgery: A randomised double-blind study","volume":"34","author":"HE Elsersy","year":"2017","journal-title":"Eur J Anaesthesiol"},{"key":"pone.0281457.ref010","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1038\/bmt.2012.244","article-title":"Investigation of the freely available easy-to-use software \u2019EZR\u2019 for medical statistics.","volume":"48","author":"Y. Kanda","year":"2013","journal-title":"Bone Marrow Transplant"},{"key":"pone.0281457.ref011","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1097\/ALN.0b013e318210483d","article-title":"Magnesium\u2014essentials for anesthesiologists","volume":"114","author":"S Herroeder","year":"2011","journal-title":"Anesthesiology"},{"key":"pone.0281457.ref012","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1111\/anae.12380","article-title":"The effect of magnesium sulphate infusion on the incidence and severity of emergence agitation in children undergoing adenotonsillectomy using sevoflurane anaesthesia.","volume":"68","author":"M Abdulatif","year":"2013","journal-title":"Anaesthesia"},{"key":"pone.0281457.ref013","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1097\/ALN.0b013e318297630d","article-title":"Perioperative systemic magnesium to minimize postoperative pain: a meta-analysis of randomized controlled trials","volume":"119","author":"GS De Oliveira","year":"2013","journal-title":"Anesthesiology"},{"key":"pone.0281457.ref014","first-page":"289","article-title":"The effect of preemptive intravenous low-dose magnesium sulfate on early postoperative pain after laparoscopic cholecystectomy","volume":"52","author":"IB Kocman","year":"2013","journal-title":"Acta Clin Croat"},{"key":"pone.0281457.ref015","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1684\/mrh.2014.0349","article-title":"Systemic magnesium to improve quality of post-surgical recovery in outpatient segmental mastectomy: a randomized, double-blind, placebo-controlled trial.","volume":"26","author":"GS De Oliveira","year":"2013","journal-title":"Magnes Res"},{"key":"pone.0281457.ref016","doi-asserted-by":"crossref","first-page":"4976","DOI":"10.1007\/s00464-016-4842-9","article-title":"Prospective, randomized and controlled trial on magnesium sulfate administration during laparoscopic gastrectomy: effects on surgical space conditions and recovery profiles.","volume":"30","author":"JH Ryu","year":"2016","journal-title":"Surg Endosc"},{"key":"pone.0281457.ref017","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1097\/EJA.0000000000000641","article-title":"Magnesium sulphate improves pulmonary function after video-assisted thoracoscopic surgery: A randomised double-blind placebo-controlled study","volume":"34","author":"HM Sohn","year":"2017","journal-title":"Eur J Anaesthesiol"},{"key":"pone.0281457.ref018","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s00540-016-2257-3","article-title":"Magnesium in obstetric anesthesia and intensive care.","volume":"31","author":"MS Kutlesic","year":"2017","journal-title":"J Anesth"},{"key":"pone.0281457.ref019","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1002\/jhm.1003","article-title":"Serial administration of a modified Richmond Agitation and Sedation Scale for delirium screening.","volume":"7","author":"JG Chester","year":"2012","journal-title":"J Hosp Med"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0281457","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,7]],"date-time":"2023-02-07T13:29:22Z","timestamp":1675776562000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0281457"}},"subtitle":[],"editor":[{"given":"Raphael","family":"Cinotti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2023,2,7]]},"references-count":19,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2023,2,7]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0281457","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,7]]}}}