{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T13:15:06Z","timestamp":1775481306410,"version":"3.50.1"},"reference-count":36,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2023,2,10]],"date-time":"2023-02-10T00:00:00Z","timestamp":1675987200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Introduction<\/jats:title>\n<jats:p>Despite the prevalent use of antenatal corticosteroids (ACS) to prevent preterm infants\u2019 adverse neonatal complications, there is currently no consensus on administration-to-birth intervals of ACS. International guidelines broadly agree that the administration of antenatal corticosteroids should be within 7 days prior to preterm birth. However, there is little evidence to support narrower optimal ACS administration-to-birth interval time. This study was undertaken to investigate the association between the administration-to-birth interval of ACS which is bounded by 48 hours and neonatal outcomes in very preterm infants.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Materials and methods<\/jats:title>\n<jats:p>This is a single-center prospective observational study. Data were collected prospectively from eligible infants from January 2008 to April 2014 at the Santa Clara Valley Medical Center, neonatal outcomes were compared between two groups based on the interval of antenatal corticosteroid administration-to-birth: the interval of &lt;48h, and the interval of &gt;48h. It was noted that the entire study was completed by Dongli Song et al., and uploaded the data to the DATADRYAD website. The author only used this data for secondary analysis.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>After adjusting potential confounders (gestational age, sex, birth weight, duration of cord clamping and delivery mode), the interval of &gt;48h group compared to the interval of &lt;48h group had significant reductions in mortality (OR: 0.17; 95% CI: 0.05\u20130.59), any retinopathy of prematurity (OR: 0.36; 95% CI: 0.16\u20130.82), severe retinopathy of prematurity (OR: 0.07; 95% CI: 0.01\u20130.45), any intubation (OR: 0.39; 95% CI: 0.20\u20130.75) and higher 1 min Apgar (\u03b2: 0.56; 95% CI: 0.10\u20131.02).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>This study shows that in very preterm infants, compared with the interval of ACS&lt;48h, the interval of ACS&gt;48 hours has a significant health promotion effect.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0281509","type":"journal-article","created":{"date-parts":[[2023,2,10]],"date-time":"2023-02-10T18:44:18Z","timestamp":1676054658000},"page":"e0281509","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":2,"title":["Antenatal corticosteroid administration-to-birth interval and neonatal outcomes in very preterm infants: A secondary analysis based on a prospective cohort study"],"prefix":"10.1371","volume":"18","author":[{"given":"Duan","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Ming","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9837-9669","authenticated-orcid":true,"given":"Yong","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2023,2,10]]},"reference":[{"issue":"1","key":"pone.0281509.ref001","doi-asserted-by":"crossref","first-page":"e37","DOI":"10.1016\/S2214-109X(18)30451-0","article-title":"Global, regional, and national estimates of levels of preterm birth in 2014: a systematic review and modelling analysis","volume":"7","author":"S Chawanpaiboon","year":"2019","journal-title":"Lancet Glob Health"},{"issue":"2","key":"pone.0281509.ref002","first-page":"1","article-title":"Births: Final Data for 2019","volume":"70","author":"JA Martin","year":"2021","journal-title":"Natl Vital Stat Rep"},{"issue":"7","key":"pone.0281509.ref003","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1053\/j.semperi.2017.07.009","article-title":"Epidemiology of preterm birth","volume":"41","author":"SE Purisch","year":"2017","journal-title":"Semin Perinatol"},{"issue":"5","key":"pone.0281509.ref004","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.puhe.2014.03.010","article-title":"Outcomes in preterm infants","volume":"128","author":"MJ Platt","year":"2014","journal-title":"Public Health"},{"issue":"8","key":"pone.0281509.ref005","doi-asserted-by":"crossref","first-page":"151482","DOI":"10.1016\/j.semperi.2021.151482","article-title":"Predictors of long-term neurodevelopmental outcomes of children born extremely preterm","volume":"45","author":"AJ Spittle","year":"2021","journal-title":"Semin Perinatol"},{"issue":"1","key":"pone.0281509.ref006","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1136\/archdischild-2015-309581","article-title":"Early and long-term outcome of infants born extremely preterm","volume":"102","author":"S Johnson","year":"2017","journal-title":"Arch Dis Child"},{"issue":"9","key":"pone.0281509.ref007","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1002\/pd.5664","article-title":"Controversies in antenatal corticosteroid treatment","volume":"40","author":"I Thevathasan","year":"2020","journal-title":"Prenat Diagn"},{"issue":"4","key":"pone.0281509.ref008","article-title":"Antenatal Corticosteroids: Extending the Practice for Late-Preterm and Scheduled Early-Term Deliveries?","volume":"8","author":"ZT Htun","year":"2021","journal-title":"Children (Basel)"},{"key":"pone.0281509.ref009","first-page":"CD004454","article-title":"Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth","volume":"12","author":"E McGoldrick","year":"2020","journal-title":"Cochrane Database Syst Rev"},{"key":"pone.0281509.ref010","first-page":"CD006764","article-title":"Different corticosteroids and regimens for accelerating fetal lung maturation for babies at risk of preterm birth","volume":"8","author":"MJ Williams","year":"2022","journal-title":"Cochrane Database Syst Rev"},{"key":"pone.0281509.ref011","unstructured":"WHO Recommendations on Interventions to Improve Preterm Birth Outcomes. Geneva: World Health Organization. 2015."},{"key":"pone.0281509.ref012","unstructured":"UK NCCF. Preterm Labour and Birth. London: National Institute for Health and Care Excellence (UK). 2015."},{"issue":"2","key":"pone.0281509.ref013","doi-asserted-by":"crossref","first-page":"e102","DOI":"10.1097\/AOG.0000000000002237","article-title":"Committee Opinion No. 713: Antenatal Corticosteroid Therapy for Fetal Maturation","volume":"130","year":"2017","journal-title":"Obstet Gynecol"},{"issue":"1","key":"pone.0281509.ref014","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S1701-2163(16)31081-7","article-title":"RETIRED: Antenatal corticosteroid therapy for fetal maturation","volume":"25","author":"J Crane","year":"2003","journal-title":"J Obstet Gynaecol Can"},{"issue":"6","key":"pone.0281509.ref015","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1080\/14767050600715873","article-title":"The first 48 hours: Comparing 12-hour and 24-hour betamethasone dosing when preterm deliveries occur rapidly","volume":"19","author":"DM Haas","year":"2006","journal-title":"J Matern Fetal Neonatal Med"},{"issue":"7","key":"pone.0281509.ref016","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1001\/jamapediatrics.2017.0602","article-title":"Association of Short Antenatal Corticosteroid Administration-to-Birth Intervals With Survival and Morbidity Among Very Preterm Infants: Results From the EPICE Cohort","volume":"171","author":"M Norman","year":"2017","journal-title":"Jama Pediatr"},{"issue":"10","key":"pone.0281509.ref017","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1111\/1471-0528.14545","article-title":"Timing of antenatal corticosteroid administration and survival in extremely preterm infants: a national population-based cohort study","volume":"124","author":"H Norberg","year":"2017","journal-title":"BJOG"},{"issue":"9","key":"pone.0281509.ref018","doi-asserted-by":"crossref","first-page":"e0138829","DOI":"10.1371\/journal.pone.0138829","article-title":"Duration of Cord Clamping and Neonatal Outcomes in Very Preterm Infants","volume":"10","author":"D Song","year":"2015","journal-title":"Plos One"},{"key":"pone.0281509.ref019","unstructured":"Preterm labour and birth. London: National Institute for Health and Care Excellence (NICE). 2019."},{"issue":"9","key":"pone.0281509.ref020","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1016\/j.jogc.2018.04.018","article-title":"No. 364-Antenatal Corticosteroid Therapy for Improving Neonatal Outcomes","volume":"40","author":"A Skoll","year":"2018","journal-title":"J Obstet Gynaecol Can"},{"issue":"5","key":"pone.0281509.ref021","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1016\/S0002-9378(96)70581-1","article-title":"Minimum interval from fetal betamethasone treatment to postnatal lung responses in preterm lambs","volume":"174","author":"M Ikegami","year":"1996","journal-title":"Am J Obstet Gynecol"},{"issue":"2","key":"pone.0281509.ref022","doi-asserted-by":"crossref","first-page":"183.e1","DOI":"10.1016\/j.ajog.2019.08.046","article-title":"The duration of fetal antenatal steroid exposure determines the durability of preterm ovine lung maturation","volume":"222","author":"MW Kemp","year":"2020","journal-title":"Am J Obstet Gynecol"},{"issue":"4","key":"pone.0281509.ref023","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1016\/j.ajog.2004.06.049","article-title":"Characterization of corticosteroid redosing in an in vitro cell line model","volume":"191","author":"AC Vidaeff","year":"2004","journal-title":"Am J Obstet Gynecol"},{"issue":"3","key":"pone.0281509.ref024","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1080\/14767050410001668248","article-title":"In vitro quantification of dexamethasone-induced surfactant protein B expression in human lung cells","volume":"15","author":"AC Vidaeff","year":"2004","journal-title":"J Matern Fetal Neonatal Med"},{"issue":"3","key":"pone.0281509.ref025","doi-asserted-by":"crossref","first-page":"256.e1","DOI":"10.1016\/j.ajog.2013.06.020","article-title":"Optimal time interval between a single course of antenatal corticosteroids and delivery for reduction of respiratory distress syndrome in preterm twins","volume":"209","author":"JY Kuk","year":"2013","journal-title":"Am J Obstet Gynecol"},{"issue":"5","key":"pone.0281509.ref026","doi-asserted-by":"crossref","first-page":"100426","DOI":"10.1016\/j.ajogmf.2021.100426","article-title":"Time interval from late preterm antenatal corticosteroid administration to delivery and the impact on neonatal outcomes","volume":"3","author":"M Gulersen","year":"2021","journal-title":"Am J Obstet Gynecol MFM"},{"issue":"7","key":"pone.0281509.ref027","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1001\/jamapediatrics.2017.0602","article-title":"Association of Short Antenatal Corticosteroid Administration-to-Birth Intervals With Survival and Morbidity Among Very Preterm Infants: Results From the EPICE Cohort","volume":"171","author":"M Norman","year":"2017","journal-title":"Jama Pediatr"},{"issue":"17","key":"pone.0281509.ref028","doi-asserted-by":"crossref","DOI":"10.3390\/ijms231710186","article-title":"Antenatal Glucocorticoid Administration Promotes Cardiac Structure and Energy Metabolism Maturation in Preterm Fetuses","volume":"23","author":"K Sakurai","year":"2022","journal-title":"Int J Mol Sci"},{"issue":"26","key":"pone.0281509.ref029","doi-asserted-by":"crossref","first-page":"2515","DOI":"10.1056\/NEJMra1208129","article-title":"Mechanisms and management of retinopathy of prematurity","volume":"367","author":"ME Hartnett","year":"2012","journal-title":"N Engl J Med"},{"issue":"15","key":"pone.0281509.ref030","article-title":"New Aspects on the Treatment of Retinopathy of Prematurity: Currently Available Therapies and Emerging Novel Therapeutics","volume":"23","author":"J. Ryu","year":"2022","journal-title":"Int J Mol Sci"},{"issue":"1","key":"pone.0281509.ref031","doi-asserted-by":"crossref","first-page":"20","DOI":"10.4103\/2249-4847.128724","article-title":"Retinopathy of prematurity: risk factors and role of antenatal betamethasone in Indian preterm newborn babies","volume":"3","author":"B Maini","year":"2014","journal-title":"J Clin Neonatol"},{"issue":"5","key":"pone.0281509.ref032","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1001\/archopht.116.5.601","article-title":"Antenatal dexamethasone and decreased severity of retinopathy of prematurity","volume":"116","author":"RD Higgins","year":"1998","journal-title":"Arch Ophthalmol"},{"key":"pone.0281509.ref033","doi-asserted-by":"crossref","first-page":"759742","DOI":"10.3389\/fphar.2022.759742","article-title":"Beyond Fetal Immunity: A Systematic Review and Meta-Analysis of the Association Between Antenatal Corticosteroids and Retinopathy of Prematurity","volume":"13","author":"Y Zeng","year":"2022","journal-title":"Front Pharmacol"},{"issue":"6","key":"pone.0281509.ref034","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1097\/AOG.0000000000000840","article-title":"Association Between Antenatal Corticosteroid Administration-to-Birth Interval and Outcomes of Preterm Neonates","volume":"125","author":"N Melamed","year":"2015","journal-title":"Obstet Gynecol"},{"issue":"1","key":"pone.0281509.ref035","first-page":"60","article-title":"Influence of the Interval between Antenatal Corticosteroid Therapy and Delivery on the Incidence of Respiratory Distress Syndrome in Neonate","volume":"29","author":"RK Karmoker","year":"2020","journal-title":"Mymensingh Med J"},{"issue":"5","key":"pone.0281509.ref036","doi-asserted-by":"crossref","first-page":"457.e1","DOI":"10.1016\/j.ajog.2006.12.018","article-title":"The effect of a prolonged time interval between antenatal corticosteroid administration and delivery on outcomes in preterm neonates: a cohort study","volume":"196","author":"AM Ring","year":"2007","journal-title":"Am J Obstet Gynecol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0281509","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,10]],"date-time":"2023-02-10T18:44:49Z","timestamp":1676054689000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0281509"}},"subtitle":[],"editor":[{"given":"Ahmed Mohamed","family":"Maged","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2023,2,10]]},"references-count":36,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2023,2,10]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0281509","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,10]]}}}