{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T04:19:09Z","timestamp":1747196349901,"version":"3.40.5"},"reference-count":37,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2023,3,23]],"date-time":"2023-03-23T00:00:00Z","timestamp":1679529600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"French Ministry of Health, Inserm, SPILF, and the Pfizer Pharmaceutical company"},{"name":"This work was supported by the Assistance Publique Hopitaux de Paris, French Ministry of Health, Inserm, SPILF, and the Pfizer Pharmaceutical company, which also funded ORP"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>Community Acute Bacterial Meningitis (CABM) is a rare infectious disease leading to important impairments. Our aim was to describe CABM survivors\u2019 quality of life (QOL) 12 months post-CABM and to assess its associations with CABM sequelae.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>Patients included in the CABM COMBAT cohort were evaluated one year after the CABM episode. Data were collected by questionnaire, via phone calls with the patients. The WHOQOL-BREF was used to measure CABM survivors\u2019 QOL. Hierarchical multivariate linear regressions were performed.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>Study population was composed of 284 patients. At 12 months, 53.9% (153\/284) reported at least incident headache\/worsening headache intensity at 12 months post-CABM, and\/or incident hearing impairment, and\/or unfavourable disability outcome (GOS). Unfavourable disability outcome was associated with lower physical health QOL (B = -30.35, p&lt;0.001), lower mental health QOL (B = -15.31, p&lt;0.001), lower environmental QOL (B = -11.08, p&lt;0.001) and lower social relationships QOL (B = -9.62, p&lt;0.001). Incident headache\/worsening headache since meningitis onset was associated with lower psychological health (B = -5.62, p = 0.010). Incident hearing impairment was associated with lower physical QOL (B = -5.34, p = 0.030). Hierarchical regressions showed that CABM impairments significantly increase explanatory power of multivariate models (for physical health R<jats:sup>2<\/jats:sup> change = 0.42, p&lt;0.001, for psychological health R<jats:sup>2<\/jats:sup> change = 0.23, p&lt;0.001, for social relationships R<jats:sup>2<\/jats:sup> change = 0.06, p&lt;0.001 and for environment domain R<jats:sup>2<\/jats:sup> change was 0.15, p&lt;0.001).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusions<\/jats:title>\n<jats:p>12 month-CABM burden is heavy. Early detection and management of CABM impairments should be performed in clinical practice as early as possible to optimize patients\u2019 psychological and psychosocial functioning.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec005\">\n<jats:title>ClinicalTrial. Gov identification number<\/jats:title>\n<jats:p><jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT01730690\" xlink:type=\"simple\">NCT01730690<\/jats:ext-link>.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0281544","type":"journal-article","created":{"date-parts":[[2023,3,23]],"date-time":"2023-03-23T18:10:22Z","timestamp":1679595022000},"page":"e0281544","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mid-term health-related quality of life in community-acquired bacterial meningitis survivors; the COMBAT study"],"prefix":"10.1371","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3122-2223","authenticated-orcid":true,"given":"Claire","family":"Della Vecchia","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9e Vicentia","family":"Ebah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Tubiana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Guimard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lionel","family":"Piroth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylvain","family":"Jaffuel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabelle","family":"Gorenne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno","family":"Mourvillier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno","family":"Hoen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xavier","family":"Duval","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie","family":"Pr\u00e9au","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2023,3,23]]},"reference":[{"issue":"18","key":"pone.0281544.ref001","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1056\/NEJMoa040845","article-title":"Clinical features and prognostic factors in adults with bacterial meningitis","volume":"351","author":"D van de Beek","year":"2004","journal-title":"N Engl J Med"},{"issue":"1","key":"pone.0281544.ref002","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1056\/NEJMra052116","article-title":"Community-acquired bacterial meningitis in adults","volume":"354","author":"D van de Beek","year":"2006","journal-title":"N Engl J Med"},{"issue":"3","key":"pone.0281544.ref003","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1128\/CMR.00070-09","article-title":"Epidemiology, Diagnosis, and Antimicrobial Treatment of Acute Bacterial Meningitis","volume":"23","author":"MC Brouwer","year":"2010","journal-title":"Clin Microbiol Rev"},{"issue":"18","key":"pone.0281544.ref004","doi-asserted-by":"crossref","first-page":"1826","DOI":"10.1056\/NEJMp048246","article-title":"Bacterial meningitis\u2014a view of the past 90 years","volume":"351","author":"MN Swartz","year":"2004","journal-title":"N Engl J Med"},{"issue":"10","key":"pone.0281544.ref005","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1136\/jnnp.2006.110023","article-title":"Cognitive outcome in adults after bacterial meningitis","volume":"78","author":"M Hoogman","year":"2007","journal-title":"J Neurol Neurosurg Psychiatry. oct"},{"issue":"1","key":"pone.0281544.ref006","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.jinf.2016.04.009","article-title":"Neurological sequelae of bacterial meningitis","volume":"73","author":"MJ Lucas","year":"2016","journal-title":"J Infect"},{"issue":"0","key":"pone.0281544.ref007","article-title":"Community-acquired bacterial meningitis in adults: in-hospital prognosis, long-term disability and determinants of outcome in a multicentre prospective cohort","volume":"0","author":"S Tubiana","year":"2020","journal-title":"Clinical Microbiology and Infection [Internet]"},{"key":"pone.0281544.ref008","doi-asserted-by":"crossref","first-page":"16074","DOI":"10.1038\/nrdp.2016.74","article-title":"Community-acquired bacterial meningitis","volume":"2","author":"D van de Beek","year":"2016","journal-title":"Nat Rev Dis Primers"},{"key":"pone.0281544.ref009","unstructured":"World Health Organization. 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