{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T08:13:25Z","timestamp":1785399205680,"version":"3.56.0"},"reference-count":82,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2023,2,16]],"date-time":"2023-02-16T00:00:00Z","timestamp":1676505600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"NSERC Discovery Grants","award":["RGPIN-2020-061130"],"award-info":[{"award-number":["RGPIN-2020-061130"]}]},{"name":"NSERC Discovery Grants","award":["RGPIN-2017-06402"],"award-info":[{"award-number":["RGPIN-2017-06402"]}]},{"name":"NSERC Discovery Grants","award":["RGPIN-2019-05775"],"award-info":[{"award-number":["RGPIN-2019-05775"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>\n                    In insects, the biogenic amines octopamine (OA) and tyramine (TA) are involved in controlling several physiological and behavioural processes. OA and TA act as neurotransmitters, neuromodulators or neurohormones, performing their functions by binding to specific receptors belonging to the G protein-coupled receptor (GPCR) superfamily. OA and TA along with their receptors are involved in reproduction, smell perception, metabolism, and homeostasis. Moreover, OA and TA receptors are targets for insecticides and antiparasitic agents, such as the formamidine Amitraz. In the dengue and yellow fever vector,\n                    <jats:italic>Aedes aegypti<\/jats:italic>\n                    , limited research has been reported on their OA or TA receptors. Here, we identify and molecularly characterize the OA and TA receptors in\n                    <jats:italic>A<\/jats:italic>\n                    .\n                    <jats:italic>aegypti<\/jats:italic>\n                    . Bioinformatic tools were used to identify four OA and three TA receptors in the genome of\n                    <jats:italic>A<\/jats:italic>\n                    .\n                    <jats:italic>aegypti<\/jats:italic>\n                    . The seven receptors are expressed in all developmental stages of\n                    <jats:italic>A<\/jats:italic>\n                    .\n                    <jats:italic>aegypti<\/jats:italic>\n                    ; however, their highest transcript abundance is observed in the adult. Among several adult\n                    <jats:italic>A<\/jats:italic>\n                    .\n                    <jats:italic>aegypti<\/jats:italic>\n                    tissues examined, including the central nervous system, antennae and rostrum, midgut, Malpighian tubules, ovaries, and testes, the type 2 TA receptor (TAR2) transcript is most abundant in the ovaries and the type 3 TA receptor (TAR3) is enriched in the Malpighian tubules, leading us to propose putative roles for these receptors in reproduction and diuresis, respectively. Furthermore, a blood meal influenced OA and TA receptor transcript expression patterns in adult female tissues at several time points post blood meal, suggesting these receptors may play key physiological roles associated with feeding. To better understand OA and TA signalling in\n                    <jats:italic>A<\/jats:italic>\n                    .\n                    <jats:italic>aegypti<\/jats:italic>\n                    , the transcript expression profiles of key enzymes in their biosynthetic pathway, namely tyrosine decarboxylase (\n                    <jats:italic>Tdc<\/jats:italic>\n                    ) and tyramine \u03b2-hydroxylase (\n                    <jats:italic>T\u03b2h<\/jats:italic>\n                    ), were examined in developmental stages, adult tissues, and brains from blood-fed females. These findings provide information for better understanding the physiological roles of OA, TA, and their receptors in\n                    <jats:italic>A<\/jats:italic>\n                    .\n                    <jats:italic>aegypti<\/jats:italic>\n                    , and additionally, may help in the development of novel strategies for the control of these human disease vectors.\n                  <\/jats:p>","DOI":"10.1371\/journal.pone.0281917","type":"journal-article","created":{"date-parts":[[2023,2,16]],"date-time":"2023-02-16T13:41:57Z","timestamp":1676554917000},"page":"e0281917","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":30,"title":["Octopamine and tyramine signalling in Aedes aegypti: Molecular characterization and insight into potential physiological roles"],"prefix":"10.1371","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5558-9156","authenticated-orcid":true,"given":"Luca","family":"Finetti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7761-0590","authenticated-orcid":true,"given":"Jean-Paul","family":"Paluzzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"Orchard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2195-4316","authenticated-orcid":true,"given":"Angela B.","family":"Lange","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2023,2,16]]},"reference":[{"key":"pone.0281917.ref001","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.ijid.2017.11.026","article-title":"Global risk mapping for major diseases transmitted by Aedes aegypti and Aedes albopictus","volume":"67","author":"S Leta","year":"2018","journal-title":"International Journal of Infectious Diseases"},{"issue":"6","key":"pone.0281917.ref002","doi-asserted-by":"crossref","first-page":"671","DOI":"10.5811\/westjem.2016.9.30904","article-title":"Dengue, Zika and Chikungunya: Emerging arboviruses in the new world","volume":"17","author":"J Patterson","year":"2016","journal-title":"The Western Journal of Emergency Medicine"},{"issue":"4","key":"pone.0281917.ref003","doi-asserted-by":"crossref","first-page":"e107","DOI":"10.1016\/S1473-3099(16)30385-1","article-title":"Chikungunya virus: an update on the biology and pathogenesis of this emerging pathogen","volume":"17","author":"FJ Burt","year":"2017","journal-title":"Lancet Infect Diseases"},{"issue":"4","key":"pone.0281917.ref004","doi-asserted-by":"crossref","first-page":"305","DOI":"10.4103\/0972-9062.197260","article-title":"Zika virus infection: past and present of another emerging vector-borne disease","volume":"53","author":"H Sakkas","year":"2016","journal-title":"Journal of Vector Borne Diseases"},{"key":"pone.0281917.ref005","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.envres.2019.02.026","article-title":"Climate change may enable Aedes aegypti infestation in major European cities by 2100","volume":"172","author":"J Liu-Helmersson","year":"2019","journal-title":"Environmental Research"},{"issue":"8","key":"pone.0281917.ref006","first-page":"CD012759","article-title":"Control methods for Aedes albopictus and Aedes aegypti","author":"P Weeratunga","year":"2017","journal-title":"The Cochrane Database of Systematic Reviews"},{"issue":"1","key":"pone.0281917.ref007","first-page":"10","article-title":"A review of the control of Aedes aegypti (Diptera: Culicidae) in the continental United States","volume":"58","author":"L Bethany","year":"2021","journal-title":"Journal of Medical Entomology"},{"issue":"5","key":"pone.0281917.ref008","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.asd.2011.01.004","article-title":"Distribution of serotonin (5-HT) and its receptors in the insect brain with focus on the mushroom bodies: lessons from Drosophila melanogaster and Apis mellifera","volume":"40","author":"W Blenau","year":"2011","journal-title":"Arthropod Structure & Development"},{"issue":"1","key":"pone.0281917.ref009","first-page":"e314","article-title":"Serotonin, serotonin receptors and their actions in insects","volume":"2","author":"H Verlinder","year":"2015","journal-title":"NeuroTransmitters"},{"key":"pone.0281917.ref010","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.ibmb.2018.04.005","article-title":"Dopamine signalling in locusts and other insects","volume":"97","author":"H. 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