{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T14:56:19Z","timestamp":1790866579914,"version":"4.1.0"},"reference-count":51,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"French Ministery of Health","award":["PHRC IR 2006 N\u00b02008-A00343-52"],"award-info":[{"award-number":["PHRC IR 2006 N\u00b02008-A00343-52"]}]},{"DOI":"10.13039\/501100005897","name":"Soci\u00e9t\u00e9 Fran\u00e7aise de Dermatologie et de Pathologie Sexuellement Transmissible","doi-asserted-by":"publisher","award":["2010"],"award-info":[{"award-number":["2010"]}],"id":[{"id":"10.13039\/501100005897","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"\nBackground<\/jats:title>\nSkin-restricted lupus is a chronic inflammatory disease associated with high rates of depression and anxiety disorders. Patients without psychiatric disorders can experience anxiety and depressive symptoms at a subclinical level, which could be risk factors for progression towards psychiatric disorders. It was decided, therefore, to investigate the presence of specific symptoms in skin-restricted lupus patients without axis I psychiatric disorders and their impact on the occurrence of axis I psychiatric disorders during the study follow-up.<\/jats:p>\n<\/jats:sec>\n\nMethods<\/jats:title>\nLongitudinal data of 38 patients and 76 matched controls without active axis I psychiatric disorders from the LuPsy cohort were used. Depressive, neurovegetative, psychic and somatic anxiety symptom scores were established from the Montgomery-Asberg Depression Rating Scale (MADRS) and the Hamilton Anxiety Rating scale (HAMA).<\/jats:p>\n<\/jats:sec>\n\nResults<\/jats:title>\nNone of the participants had any current active axis I psychiatric disorders but the patients had personality disorders more frequently and had received more past psychotropic treatments than the controls. They also had higher MADRS and HAMA scores than the controls, in particular neurovegetative, psychic anxiety and somatic symptoms scores. No dermatological factor tested was associated with these scores, whereas being a lupus patient was associated with higher neurovegetative and somatic symptoms scores, having a current personality disorder with higher depressive and neurovegetative scores and receiving more past psychotropic treatments with psychic anxiety and somatic symptoms scores. The occurrence of psychiatric disorders during the study follow-up was associated with an elevated psychic anxiety score at baseline and past psychotropic treatment but not with history of psychiatric disorder.<\/jats:p>\n<\/jats:sec>\n\nLimitations<\/jats:title>\nThe LuPsy cohort included a large number of patients with axis I psychiatric disorders, the sample without axis I psychiatric disorders is therefore limited.<\/jats:p>\n<\/jats:sec>\n\nConclusions<\/jats:title>\nWe observed numerous psychiatric symptoms among the skin-restricted lupus patients. They should therefore receive special attention in the management of their subclinical symptoms before they progress towards full psychiatric disorders.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0282079","type":"journal-article","created":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T18:29:22Z","timestamp":1677695362000},"page":"e0282079","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":1,"title":["Psychiatric symptomatology in skin-restricted lupus patients without axis I psychiatric disorders: A post-hoc analysis"],"prefix":"10.1371","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8998-1559","authenticated-orcid":true,"given":"Fabien","family":"Rondepierre","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Urbain","family":"Tauveron-Jalenques","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sol\u00e8ne","family":"Valette","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aur\u00e9lien","family":"Mulliez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"D\u2019Incan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Lauron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8331-4544","authenticated-orcid":true,"given":"Isabelle","family":"Jalenques","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2023,3,1]]},"reference":[{"issue":"2","key":"pone.0282079.ref001","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.cyto.2015.01.031","article-title":"The role of cytokines in the pathogenesis of cutaneous lupus erythematosus","volume":"73","author":"ES Robinson","year":"2015","journal-title":"Cytokine"},{"issue":"2","key":"pone.0282079.ref002","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.jaad.2015.09.016","article-title":"A cross-sectional study of untreated depression and anxiety in cutaneous lupus erythematosus and dermatomyositis","volume":"74","author":"J Achtman","year":"2016","journal-title":"J Am Acad Dermatol"},{"issue":"5","key":"pone.0282079.ref003","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1111\/bjd.14392","article-title":"High prevalence of psychiatric disorders in patients with skin-restricted lupus: a case-control study","volume":"174","author":"I Jalenques","year":"2016","journal-title":"Br J Dermatol"},{"issue":"6","key":"pone.0282079.ref004","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1038\/jid.2013.508","article-title":"The prevalence and odds of depressive symptoms and clinical depression in psoriasis patients: a systematic review and meta-analysis","volume":"134","author":"EA Dowlatshahi","year":"2014","journal-title":"J Invest Dermatol"},{"issue":"1","key":"pone.0282079.ref005","doi-asserted-by":"crossref","first-page":"2","DOI":"10.4103\/0974-7753.136746","article-title":"A review of psychiatric disorders comorbidities in patients with alopecia areata","volume":"6","author":"A Ghanizadeh","year":"2014","journal-title":"Int J Trichology"},{"key":"pone.0282079.ref006","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.jpsychores.2017.07.015","article-title":"Increased incidence of psychiatric disorders in immune-mediated inflammatory disease.","volume":"101","author":"RA Marrie","year":"2017","journal-title":"J Psychosom Res"},{"issue":"7","key":"pone.0282079.ref007","doi-asserted-by":"crossref","first-page":"993","DOI":"10.4088\/JCP.11r07425","article-title":"Psychiatric symptoms in systemic lupus erythematosus: a systematic review","volume":"73","author":"ZS Meszaros","year":"2012","journal-title":"J Clin Psychiatry"},{"issue":"3","key":"pone.0282079.ref008","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.jaad.2018.03.017","article-title":"Association of atopic dermatitis with depression, anxiety, and suicidal ideation in children and adults: A systematic review and meta-analysis","volume":"79","author":"ATM R\u00f8nnstad","year":"2018","journal-title":"J Am Acad Dermatol"},{"issue":"1","key":"pone.0282079.ref009","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1186\/s12888-017-1234-1","article-title":"Prevalence of depression and anxiety in systemic lupus erythematosus: a systematic review and meta-analysis","volume":"17","author":"L Zhang","year":"2017","journal-title":"BMC Psychiatry"},{"issue":"1","key":"pone.0282079.ref010","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/nrn2297","article-title":"\u2019Connor JC, Freund GG, Johnson RW, Kelley KW. 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