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Calorie restriction (CR) can modulate estrogen deficiency and obesity-related cardiovascular diseases. The protective effects of CR and estradiol on cardiac hypertrophy in ovariectomized obese rats were explored in this study. The adult female Wistar rats were divided into sham and ovariectomized (OVX) groups that received a high-fat diet (60% HFD) or standard diet (SD) or 30% CR for 16 weeks, and then, 1mg\/kg E2 (17-\u03b2 estradiol) was injected intraperitoneally every 4 days for four weeks in OVX-rats. Hemodynamic parameters were evaluated before and after each diet. Heart tissues were collected for biochemical, histological, and molecular analysis. HFD consumption led to weight gain in sham and OVX rats. In contrast, CR and E2 led to body weight loss in these animals. Also, heart weight (HW), heart weight\/body weight (HW\/BW) ratio, and left ventricular weight (LVW) were enhanced in OVX rats that received SD and HFD. E2 reduced these indexes in both diet conditions but reduction effects of CR were seen only in HFD groups. HFD and SD feeding increased hemodynamic parameters, ANP (atrial natriuretic peptide) mRNA expression, and TGF-\u03b21(transforming growth factor-beta 1) protein level in the OVX animals, while CR and E2 reduced these factors. Cardiomyocyte diameter and hydroxyproline content were increased in the OVX-HFD groups. Nevertheless, CR and E2 decreased these indicators. The results showed that CR and E2 treatment reduced obesity-induced-cardiac hypertrophy in ovariectomized groups (20% and 24% respectively). CR appears to have almost as reducing effects as estrogen therapy on cardiac hypertrophy. The findings suggest that CR can be considered a therapeutic candidate for postmenopausal cardiovascular disease.<\/jats:p>","DOI":"10.1371\/journal.pone.0282089","type":"journal-article","created":{"date-parts":[[2023,4,25]],"date-time":"2023-04-25T13:29:47Z","timestamp":1682429387000},"page":"e0282089","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":5,"title":["RETRACTED: Protective effects of calorie restriction and 17-\u03b2 estradiol on cardiac hypertrophy in ovariectomized obese rats"],"prefix":"10.1371","volume":"18","author":[{"given":"Zahra","family":"Hajializadeh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0770-4281","authenticated-orcid":true,"given":"Mohammad","family":"Khaksari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahriar","family":"Dabiri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatemeh","family":"Darvishzadeh Mahani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alireza","family":"Raji-Amirhasani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Abbas","family":"Bejeshk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2023,4,25]]},"reference":[{"key":"pone.0282089.ref001","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.regpep.2010.12.009","article-title":"Natriuretic peptide system: a link between fat mass and cardiac hypertrophy and hypertension in fat-fed female rats","volume":"167","author":"EN de Andrade","year":"2011","journal-title":"Regul Pept"},{"key":"pone.0282089.ref002","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1126\/science.1112062","article-title":"Molecular and cellular basis of cardiovascular gender differences","volume":"308","author":"ME Mendelsohn","year":"2005","journal-title":"Science"},{"key":"pone.0282089.ref003","doi-asserted-by":"crossref","first-page":"48","DOI":"10.7326\/0003-4819-67-1-48","article-title":"The relation of adiposity to blood pressure and development of hypertension. 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