{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T15:26:16Z","timestamp":1780413976760,"version":"3.54.1"},"reference-count":69,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2023,3,9]],"date-time":"2023-03-09T00:00:00Z","timestamp":1678320000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>The Anterior Cruciate Ligament (ACL) rupture is a very common knee injury during sport activities. Landing after jump is one of the most prominent human body movements that can lead to such an injury. The landing-related ACL injury risk factors have been in the spotlight of research interest. Over the years, researchers and clinicians acquire knowledge about human movement during daily-life activities by organizing complex <jats:italic>in vivo<\/jats:italic> studies that feature high complexity, costs and technical and most importantly physical challenges. In an attempt to overcome these limitations, this paper introduces a computational modeling and simulation pipeline that aims to predict and identify key parameters of interest that are related to ACL injury during single-leg landings. We examined the following conditions: a) landing height, b) hip internal and external rotation, c) lumbar forward and backward leaning, d) lumbar medial and lateral bending, e) muscle forces permutations and f) effort goal weight. Identified on related research studies, we evaluated the following risk factors: vertical Ground Reaction Force (vGRF), knee joint Anterior force (AF), Medial force (MF), Compressive force (CF), Abduction moment (AbdM), Internal rotation moment (IRM), quadricep and hamstring muscle forces and Quadriceps\/Hamstrings force ratio (Q\/H force ratio). Our study clearly demonstrated that ACL injury is a rather complicated mechanism with many associated risk factors which are evidently correlated. Nevertheless, the results were mostly in agreement with other research studies regarding the ACL risk factors. The presented pipeline showcased promising potential of predictive simulations to evaluate different aspects of complicated phenomena, such as the ACL injury.<\/jats:p>","DOI":"10.1371\/journal.pone.0282186","type":"journal-article","created":{"date-parts":[[2023,3,9]],"date-time":"2023-03-09T18:43:45Z","timestamp":1678387425000},"page":"e0282186","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":8,"title":["Predictive simulation of single-leg landing scenarios for ACL injury risk factors evaluation"],"prefix":"10.1371","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1631-7163","authenticated-orcid":true,"given":"Evgenia","family":"Moustridi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Risvas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Moustakas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2023,3,9]]},"reference":[{"key":"pone.0282186.ref001","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1016\/j.arthro.2007.07.003","article-title":"A Meta-analysis of the Incidence of Anterior Cruciate Ligament Tears as a Function of Gender, Sport, and a Knee Injury\u2013Reduction Regimen","volume":"23","author":"CC Prodromos","year":"2007","journal-title":"Arthroscopy: The Journal of Arthroscopic & 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model of the knee joint to characterize the knee extensor mechanism","volume":"22","author":"GT Yamaguchi","year":"1989","journal-title":"Journal of Biomechanics"},{"key":"pone.0282186.ref048","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.21105\/joss.01421","article-title":"SCONE: Open Source Software for Predictive Simulation of Biological Motion","volume":"4","author":"T Geijtenbeek","year":"2019","journal-title":"JOSS"},{"key":"pone.0282186.ref049","doi-asserted-by":"crossref","first-page":"e1006993","DOI":"10.1371\/journal.pcbi.1006993","article-title":"Predicting gait adaptations due to ankle plantarflexor muscle weakness and contracture using physics-based musculoskeletal simulations","volume":"15","author":"CF Ong","year":"2019","journal-title":"PLoS Comput Biol"},{"key":"pone.0282186.ref050","doi-asserted-by":"crossref","first-page":"e1008493","DOI":"10.1371\/journal.pcbi.1008493","article-title":"OpenSim Moco: Musculoskeletal optimal control","volume":"16","author":"CL Dembia","year":"2020","journal-title":"PLoS Comput Biol"},{"key":"pone.0282186.ref051","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1137\/16M1062569","article-title":"An Introduction to Trajectory Optimization: How to Do Your Own Direct Collocation","volume":"59","author":"M Kelly","year":"2017","journal-title":"SIAM Rev"},{"key":"pone.0282186.ref052","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1109\/TNSRE.2019.2924536","article-title":"Subject-Exoskeleton Contact Model Calibration Leads to Accurate Interaction Force Predictions","volume":"27","author":"G Serrancoli","year":"2019","journal-title":"IEEE Trans Neural Syst Rehabil Eng"},{"key":"pone.0282186.ref053","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1080\/10255849908907988","article-title":"A Dynamic Optimization Solution for Vertical Jumping in Three Dimensions","volume":"2","author":"FC Anderson","year":"1999","journal-title":"Computer Methods in 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