{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T04:44:44Z","timestamp":1789101884086,"version":"build-2803163510"},"reference-count":46,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2023,4,20]],"date-time":"2023-04-20T00:00:00Z","timestamp":1681948800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Science and Technology Planning Support Project of Guizhou Province","award":["Qian Ke He Support [2020]4Y143"],"award-info":[{"award-number":["Qian Ke He Support [2020]4Y143"]}]},{"name":"Science and Technology Foundation Planning Project of Guizhou Province","award":["Qian Ke He Basis [2017]1094"],"award-info":[{"award-number":["Qian Ke He Basis [2017]1094"]}]},{"name":"Infectious Disease Prevention and Control Talent Base Scientific Research Team Project of Guizhou Province","award":["RCJD2104"],"award-info":[{"award-number":["RCJD2104"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p><jats:italic>Salmonella<\/jats:italic>, one of the major causes of foodborne infections, can cause bacterial foodborne illness. We investigated the serotype distribution, multidrug resistance (MDR), and \u03b2-lactamase resistance genes of human <jats:italic>Salmonella<\/jats:italic> isolates collected from clinical specimens in Guizhou, China, between 2013 and 2018. A total of 363 <jats:italic>Salmonella<\/jats:italic> isolates were collected from clinical specimens at 17 surveillance hospitals. Twenty-four serotypes were identified by sliding agglutination test. <jats:italic>S<\/jats:italic>. Enteritidis (33.9%), <jats:italic>Salmonella<\/jats:italic> 4,[5],12:i:- (24.0%), <jats:italic>S<\/jats:italic>. Typhimurium (16.3%), <jats:italic>S<\/jats:italic>. London (6.3%), and <jats:italic>S<\/jats:italic>. Derby (3.9%) were the top five serotypes. In 2018, the most common serotype changed from <jats:italic>S<\/jats:italic>. Enteritidis to <jats:italic>S<\/jats:italic>. Typhimurium. Among the 363 <jats:italic>Salmonella<\/jats:italic> isolates, 97.5% of isolates were resistant to at least one class of antimicrobial agents. For cephalosporins, ceftriaxone had the highest resistance rate of 10.5%, and cefepime and cefoxitin were 8.0% and 2.2%, respectively. Three hundred and one (82.9%) <jats:italic>Salmonella<\/jats:italic> isolates showed MDR. <jats:italic>S<\/jats:italic>almonella 4,[5],12:i:- had the highest MDR rate with 94.2%, followed by <jats:italic>S<\/jats:italic>. London (91.3%) and <jats:italic>S<\/jats:italic>. Typhimurium (88.1%). Multidrug resistance rates of <jats:italic>Salmonella<\/jats:italic> isolates in Guizhou from 2013 to 2017 increased from 75.8% to 86.7%. Sixteen isolates (4.4%) showed extensive drug resistance. One hundred thirty-four antimicrobial resistance patterns were found. Two hundred and forty-one (66.4%) isolates carried at least one \u03b2-lactamase resistance gene. The <jats:italic>bla<\/jats:italic><jats:sub><jats:italic>TEM<\/jats:italic><\/jats:sub> gene (61.2%) was the most prevalent resistant gene in all <jats:italic>Salmonella<\/jats:italic> isolates, followed by the <jats:italic>bla<\/jats:italic><jats:sub><jats:italic>CTX-M<\/jats:italic><\/jats:sub> gene (6.1%) and <jats:italic>bla<\/jats:italic><jats:sub><jats:italic>OXA-1<\/jats:italic><\/jats:sub> gene (4.1%). Our findings showed that the MDR rate of <jats:italic>Salmonella<\/jats:italic> isolates from Guizhou province increased year by year. Therefore, systematic and long-term surveillance on MDR <jats:italic>Salmonella<\/jats:italic> isolates from clinical patients should be further strengthened.<\/jats:p>","DOI":"10.1371\/journal.pone.0282254","type":"journal-article","created":{"date-parts":[[2023,4,20]],"date-time":"2023-04-20T18:22:15Z","timestamp":1682014935000},"page":"e0282254","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":16,"title":["Serotype distribution, trend of multidrug resistance and prevalence of \u03b2-lactamase resistance genes in human Salmonella isolates from clinical specimens in Guizhou, China"],"prefix":"10.1371","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9948-664X","authenticated-orcid":true,"given":"Xiaoyu","family":"Wei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Long","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lv","family":"You","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunting","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shijun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junhua","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2023,4,20]]},"reference":[{"issue":"9","key":"pone.0282254.ref001","doi-asserted-by":"crossref","first-page":"e0221492","DOI":"10.1371\/journal.pone.0221492","article-title":"Antimicrobial resistance and molecular genotyping of Salmonella enterica serovar Enteritidis clinical isolates from Guizhou province of Southwestern China","volume":"14","author":"X Wei","year":"2019","journal-title":"Plos One"},{"issue":"6","key":"pone.0282254.ref002","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.3201\/eid2706.204486","article-title":"Increased incidence of antimicrobial-resistant Nontyphoidal Salmonella infections, United States, 2004\u20132016","volume":"27","author":"F Medalla","year":"2021","journal-title":"Emerging Infectious Disease"},{"key":"pone.0282254.ref003","doi-asserted-by":"crossref","unstructured":"EFSA-ECDC. 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