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Participants then completed a final stage to exhaustion at a running speed equivalent to the maximum achieved during the cardio-respiratory exercise test (Peak). Physiological, metabolic, and perceptual measures were measured.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Mask did not affect spirometry (forced vital capacity, peak expiratory flow, forced expiratory volume; all p\u22650.27), respiratory (inspiratory capacity, end-expiratory volume [EELV] to functional vital capacity ratio, EELV, respiratory frequency [Rf], tidal volume [VT], Rf\/VT, end-tidal carbo dioxide pressure, ventilatory equivalent to carbon dioxide ratio; all p\u22650.196), hemodynamic (heart rate, systolic and diastolic blood pressure; all p>0.41), ratings of perceived exertion (p = 0.04) or metabolic measures (lactate; p = 0.78) at rest or at any exercise intensity.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n This study shows that performing moderate to severe activity is safe and tolerable for healthy youth while wearing a cloth facemask.<\/jats:p>\n <\/jats:sec>\n \n Trial registration<\/jats:title>\n \n ClinicalTrials.gov:\n NCT04887714<\/jats:ext-link>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1371\/journal.pone.0282475","type":"journal-article","created":{"date-parts":[[2023,3,6]],"date-time":"2023-03-06T13:21:58Z","timestamp":1678108918000},"page":"e0282475","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":4,"title":["Performing moderate to severe activity is safe and tolerable for healthy youth while wearing a cloth facemask"],"prefix":"10.1371","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8712-4975","authenticated-orcid":true,"given":"Felipe Miguel","family":"Marticorena","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel Castanho","family":"Barreto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nat\u00e1lia Mendes","family":"Guardieiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel Perri","family":"Esteves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamires Nunes","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8225-5784","authenticated-orcid":true,"given":"Luana Farias","family":"de Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Lucia de S\u00e1","family":"Pinto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz","family":"Riani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danilo 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