{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T22:38:43Z","timestamp":1792103923073,"version":"4.4.0"},"reference-count":55,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T00:00:00Z","timestamp":1684281600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National New Investigator of the Heart and Stroke Foundation Canada"},{"name":"Culture Department of the City Graz","award":["A 16 \u2013 012867\/2009"],"award-info":[{"award-number":["A 16 \u2013 012867\/2009"]}]},{"DOI":"10.13039\/501100000222","name":"Heart and Stroke Foundation of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000222","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Alberta New Investigator of the Heart and Stroke Foundation Alberta"},{"name":"Stollery Children's Hospital Foundation"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Objective<\/jats:title>\n<jats:p>The association between blood glucose level and cerebral oxygenation (cerebral regional oxygen saturation [crSO<jats:sub>2<\/jats:sub>] and cerebral fractional tissue oxygen extraction [FTOE]) in neonates has already been described. Aim of the present study was to investigate if acid-base and other metabolic parameters have an impact on cerebral oxygenation immediately after birth in preterm and term neonates.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Study design<\/jats:title>\n<jats:p>Post-hoc analyses of secondary outcome parameters of two prospective observational studies were performed. Preterm and term neonates born by caesarean section were included, in whom i) cerebral near-infrared spectroscopy (NIRS) measurements were performed during the first 15 minutes after birth and ii) a capillary blood gas analysis was performed between 10 and 20 minutes after birth. Vital signs were routinely monitored with pulse oximetry (arterial oxygen saturation [SpO<jats:sub>2<\/jats:sub>] and heart rate [HR]). Correlation analyses were performed to investigate potential associations between acid-base and metabolic parameters (lactate [LAC], pH-value [pH], base-excess [BE] and bicarbonate [HCO<jats:sub>3<\/jats:sub>]) from capillary blood and NIRS-derived crSO<jats:sub>2<\/jats:sub> and FTOE at 15 minutes after birth.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>One-hundred-fifty-seven neonates, 42 preterm neonates (median gestational age [IQR] 34.0 weeks [3.3], median birth weight 1845g [592]) and 115 term neonates (median gestational age [IQR] 38.9 weeks [1.0], median birth weight 3230g [570]) were included in the study. Median crSO<jats:sub>2<\/jats:sub> [IQR] values at 15 minutes after birth were 82% [16] in preterm neonates and 83% [12] in term neonates. Median FTOE [IQR] values at 15 minutes after birth were 0.13 [0.15] in preterm neonates and 0.14 [0.14] in term neonates. In preterm neonates, higher LAC and lower pH and BE were associated with lower crSO<jats:sub>2<\/jats:sub> and higher FTOE. In term neonates, higher HCO<jats:sub>3<\/jats:sub> was associated with higher FTOE.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>There were significant associations between several acid-base and metabolic parameters and cerebral oxygenation in preterm neonates, while in term neonates only HCO<jats:sub>3<\/jats:sub> correlated positively with FTOE.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0283278","type":"journal-article","created":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T17:37:48Z","timestamp":1684345068000},"page":"e0283278","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":7,"title":["Acid-base and metabolic parameters and cerebral oxygenation during the immediate transition after birth\u2014A two-center observational study"],"prefix":"10.1371","volume":"18","author":[{"given":"Christian","family":"Mattersberger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nariae","family":"Baik-Schneditz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5499-3712","authenticated-orcid":true,"given":"Bernhard","family":"Schwaberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9798-2415","authenticated-orcid":true,"given":"Georg M.","family":"Schm\u00f6lzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3932-665X","authenticated-orcid":true,"given":"Lukas","family":"Mileder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berndt","family":"Urlesberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2405-7143","authenticated-orcid":true,"given":"Gerhard","family":"Pichler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2023,5,17]]},"reference":[{"issue":"4","key":"pone.0283278.ref001","doi-asserted-by":"crossref","first-page":"F333","DOI":"10.1136\/archdischild-2015-308829","article-title":"The SafeBoosC phase II clinical trial: An analysis of the interventions related with the oximeter readings","volume":"101","author":"J Riera","year":"2016","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"issue":"3","key":"pone.0283278.ref002","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1007\/s00421-013-2667-y","article-title":"Blood pressure regulation IX: cerebral autoregulation under blood pressure challenges","volume":"114","author":"Y-C Tzeng","year":"2014","journal-title":"Eur J Appl Physiol"},{"issue":"5","key":"pone.0283278.ref003","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.earlhumdev.2005.03.005","article-title":"Autoregulation of cerebral blood flow in newborn babies","volume":"81","author":"G. 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