{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T13:05:06Z","timestamp":1792155906721,"version":"4.4.0"},"reference-count":94,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2023,4,13]],"date-time":"2023-04-13T00:00:00Z","timestamp":1681344000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Deputyship for Research & Innovation, Ministry of Education in Saudi Arabia","award":["project number 223202"],"award-info":[{"award-number":["project number 223202"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>Non-coding RNAs (ncRNAs) can control the flux of genetic information; affect RNA stability and play crucial roles in mediating epigenetic modifications. A number of studies have highlighted the potential roles of both virus-encoded and host-encoded ncRNAs in viral infections, transmission and therapeutics. However, the role of an emerging type of non-coding transcript, circular RNA (circRNA) in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has not been fully elucidated so far. Moreover, the potential pathogenic role of circRNA-miRNA-mRNA regulatory axis has not been fully explored as yet. The current study aimed to holistically map the regulatory networks driven by SARS-CoV-2 related circRNAs, miRNAs and mRNAs to uncover plausible interactions and interplay amongst them in order to explore possible therapeutic options in SARS-CoV-2 infection. Patient datasets were analyzed systematically in a unified approach to explore circRNA, miRNA, and mRNA expression profiles. CircRNA-miRNA-mRNA network was constructed based on cytokine storm related circRNAs forming a total of 165 circRNA-miRNA-mRNA pairs. This study implies the potential regulatory role of the obtained circRNA-miRNA-mRNA network and proposes that two differentially expressed circRNAs hsa_circ_0080942 and hsa_circ_0080135 might serve as a potential theranostic agents for SARS-CoV-2 infection. Collectively, the results shed light on the functional role of circRNAs as ceRNAs to sponge miRNA and regulate mRNA expression during SARS-CoV-2 infection.<\/jats:p>","DOI":"10.1371\/journal.pone.0283589","type":"journal-article","created":{"date-parts":[[2023,4,13]],"date-time":"2023-04-13T17:45:21Z","timestamp":1681407921000},"page":"e0283589","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":15,"title":["Mapping CircRNA\u2013miRNA\u2013mRNA regulatory axis identifies hsa_circ_0080942 and hsa_circ_0080135 as a potential theranostic agents for SARS-CoV-2 infection"],"prefix":"10.1371","volume":"18","author":[{"given":"Hassan","family":"Ayaz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nouman","family":"Aslam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8146-8929","authenticated-orcid":true,"given":"Faryal Mehwish","family":"Awan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rabea","family":"Basri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bisma","family":"Rauff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Badr","family":"Alzahrani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Arif","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aqsa","family":"Ikram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayesha","family":"Obaid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anam","family":"Naz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sadiq Noor","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Burton B.","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azhar","family":"Nazir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2023,4,13]]},"reference":[{"key":"pone.0283589.ref001","first-page":"1","article-title":"SARS-CoV-2 lineages and sub-lineages circulating worldwide: a dynamic overview.","author":"E Cella","year":"2021","journal-title":"Chemotherapy"},{"key":"pone.0283589.ref002","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.3389\/fimmu.2020.01949","article-title":"Overview of immune response during SARS-CoV-2 infection: lessons from the past","volume":"11","author":"VK Shah","year":"2020","journal-title":"Frontiers in immunology"},{"issue":"1","key":"pone.0283589.ref003","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1002\/jmv.26232","article-title":"The cytokine storm and COVID\u201019","volume":"93","author":"B Hu","year":"2021","journal-title":"Journal of medical virology"},{"issue":"7","key":"pone.0283589.ref004","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1111\/all.14364","article-title":"Immune response to SARS\u2010CoV\u20102 and mechanisms of immunopathological changes in COVID\u201019","volume":"75","author":"AK Azkur","year":"2020","journal-title":"Allergy"},{"issue":"12","key":"pone.0283589.ref005","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.3390\/v12121374","article-title":"Non-coding RNAs and SARS-related coronaviruses.","volume":"12","author":"H Henzinger","year":"2020","journal-title":"Viruses"},{"key":"pone.0283589.ref006","doi-asserted-by":"crossref","first-page":"454","DOI":"10.3389\/fgene.2020.00454","article-title":"Long non-coding RNAs involved in pathogenic infection","volume":"11","author":"S Shirahama","year":"2020","journal-title":"Frontiers in Genetics"},{"key":"pone.0283589.ref007","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1146\/annurev.micro.112408.134243","article-title":"Viruses, microRNAs, and host interactions","volume":"64","author":"RL Skalsky","year":"2010","journal-title":"Annual review of microbiology"},{"key":"pone.0283589.ref008","doi-asserted-by":"crossref","first-page":"3138","DOI":"10.3389\/fimmu.2018.03138","article-title":"The opening of pandora\u2019s box: An emerging role of long noncoding RNA in viral infections.","volume":"9","author":"P. 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