{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T10:30:02Z","timestamp":1789122602330,"version":"build-2803163510"},"reference-count":67,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2023,3,30]],"date-time":"2023-03-30T00:00:00Z","timestamp":1680134400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001322","name":"South African Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007631","name":"Canadian Institute for Advanced Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007631","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005274","name":"North West University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005274","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>Anaemia continues to be a persistent concern among South African women of reproductive age (WRA), yet population specific information on its determinants remains sparse. We used baseline data from the Healthy Lives Trajectory Initiative a randomised trial (n = 480) to quantify factors associated with anaemia in Soweto, South Africa aged 18\u201325 years. We used multivariable logistic regression to describe associations with anaemia and used structural equation modelling to assess a theoretical model, which tested three categories socioeconomic status (household asset score, education level), nutritional factors (food security, leafy green vegetable and chicken and beef consumption, iron status and vitamin A status) and biodemographic factors (parity, age at start of menarche, HIV status, contraception use, anthropometry, and inflammation status). The multiple logistic regression showed that ID (OR: 2.62, 95% CI: 1.72, 3.98), iron deficiency erythropoiesis (IDE) (OR: 1.62, 95% CI: 1.07, 2.46), and elevated CRP (OR: 1.69, 95% CI: 1.04, 2.76), increased the odds of being anaemic. SEM analysis revealed Hb was directly and positively associated with adjusted ferritin (0.0031 per mg\/dL; p\u22640.001), and CRP (0.015 per mg\/dL; p\u22640.05), and directly and negatively associated with soluble transferrin receptor sTfR (-0.042 per mg\/dL; p\u22640.001). While contraception use had both a direct (0.34; p\u22640.05) and indirect (0.11; p\u22640.01) positive association with Hb. Additionally, chicken and beef consumption had a positive indirect association with Hb concentrations (0.15; p\u22640.05) through adjusted ferritin. Iron deficiency was the main anaemia risk factor in this low resource setting. However, anaemia of inflammation is present. Therefore, we suggest that in our setting, WRA anaemia control programs that include interventions to reduce ID and inflammation should be tested.<\/jats:p>","DOI":"10.1371\/journal.pone.0283645","type":"journal-article","created":{"date-parts":[[2023,3,30]],"date-time":"2023-03-30T17:42:46Z","timestamp":1680198166000},"page":"e0283645","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":9,"title":["Determinants of anaemia among women of reproductive age in South Africa: A Healthy Life Trajectories Initiative (HeLTI)"],"prefix":"10.1371","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7905-9934","authenticated-orcid":true,"given":"Takana M.","family":"Silubonde","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelius 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Dorsamy","year":"2022","journal-title":"Systematic reviews."},{"key":"pone.0283645.ref016","author":"World Health Organization","year":"2001","journal-title":"Iron deficiency anaemia: assessment, prevention, and control."},{"issue":"2","key":"pone.0283645.ref017","doi-asserted-by":"crossref","first-page":"616S","DOI":"10.1093\/jn\/131.2.616S","article-title":"Iron and its relation to immunity and infectious disease","volume":"131","author":"SJ Oppenheimer","year":"2001","journal-title":"The Journal of nutrition"},{"issue":"9","key":"pone.0283645.ref018","doi-asserted-by":"crossref","first-page":"e0221299","DOI":"10.1371\/journal.pone.0221299","article-title":"Maternal iron-deficiency is associated with premature birth and higher birth weight despite routine antenatal iron supplementation in an urban South African setting: The NuPED prospective study.","volume":"14","author":"EA Symington","year":"2019","journal-title":"PloS 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SANHANES\u20101","volume":"1416","author":"ZJ Mchiza","year":"2018","journal-title":"Annals of the New York Academy of Sciences"},{"key":"pone.0283645.ref025","doi-asserted-by":"crossref","first-page":"100846","DOI":"10.1016\/j.pmedr.2019.100846","article-title":"Urban young women\u2019s preferences for intervention strategies to promote physical and mental health preconception: A Healthy Life Trajectories Initiative (HeLTI).","volume":"14","author":"C Draper","year":"2019","journal-title":"Preventive medicine reports."},{"issue":"3","key":"pone.0283645.ref026","doi-asserted-by":"crossref","first-page":"633","DOI":"10.3390\/nu12030633","article-title":"Adjusting haemoglobin values for altitude maximizes combined sensitivity and specificity to detect iron deficiency among women of reproductive age in Johannesburg, South Africa","volume":"12","author":"TM Silubonde","year":"2020","journal-title":"Nutrients"},{"key":"pone.0283645.ref027","article-title":"South African national HIV 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iron status and iron deficiency in populations","author":"World Health Organization","year":"2011"},{"key":"pone.0283645.ref031","volume-title":"Haemoglobin concentrations for the diagnosis of anaemia and assessment of severity","author":"World Health Organization","year":"2011"},{"issue":"1","key":"pone.0283645.ref032","first-page":"11","article-title":"The development of MUAC-for-age reference data recommended by a WHO Expert Committee","volume":"75","author":"M De Onis","year":"1997","journal-title":"Bulletin of the World Health Organization"},{"issue":"7","key":"pone.0283645.ref033","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1017\/S136898002100046X","article-title":"Food insecurity, diet quality and body composition: data from the Healthy Life Trajectories Initiative (HeLTI) pilot survey in urban Soweto, South Africa.","volume":"24","author":"SH Kehoe","year":"2021","journal-title":"Public Health 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Washington","volume":"24","author":"CA Wehler","year":"1992","journal-title":"Journal of nutrition education"},{"key":"pone.0283645.ref037","doi-asserted-by":"crossref","first-page":"103208","DOI":"10.1016\/j.jbi.2019.103208","article-title":"The REDCap consortium: Building an international community of software platform partners","volume":"95","author":"PA Harris","year":"2019","journal-title":"Journal of biomedical informatics"},{"issue":"3","key":"pone.0283645.ref038","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/j.1745-3992.2007.00099.x","article-title":"Introduction to structural equation modeling: Issues and practical considerations.","volume":"26","author":"PW Lei","year":"2007","journal-title":"Educational Measurement: issues and practice."},{"issue":"1","key":"pone.0283645.ref039","doi-asserted-by":"crossref","first-page":"e16","DOI":"10.1016\/S2214-109X(13)70001-9","article-title":"Global, regional, and national trends in haemoglobin concentration and prevalence of total and severe anaemia in children and pregnant and non-pregnant women for 1995\u20132011: a systematic analysis of population-representative data","volume":"1","author":"GA Stevens","year":"2013","journal-title":"The Lancet Global Health"},{"issue":"5","key":"pone.0283645.ref040","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1182\/blood-2013-06-508325","article-title":"A systematic analysis of global anemia burden from 1990 to 2010","volume":"123","author":"NJ Kassebaum","year":"2014","journal-title":"Blood"},{"issue":"1","key":"pone.0283645.ref041","doi-asserted-by":"crossref","first-page":"402S","DOI":"10.3945\/ajcn.116.142323","article-title":"Predictors of anemia in preschool children: Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA) project.","volume":"106","author":"R Engle-Stone","year":"2017","journal-title":"The American journal of clinical nutrition"},{"issue":"1","key":"pone.0283645.ref042","doi-asserted-by":"crossref","first-page":"416S","DOI":"10.3945\/ajcn.116.143073","article-title":"Predictors of anemia in women of reproductive age: Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA) project.","volume":"106","author":"JP Wirth","year":"2017","journal-title":"The American journal of clinical nutrition"},{"issue":"3","key":"pone.0283645.ref043","first-page":"416","article-title":"High prevalence of anemia with lack of iron deficiency among women in rural Bangladesh: a role for thalassemia and iron in groundwater.","volume":"21","author":"RD Merrill","year":"2012","journal-title":"Asia Pacific journal of clinical nutrition"},{"issue":"9693","key":"pone.0283645.ref044","first-page":"934","article-title":"The burden of non-communicable diseases in South Africa","volume":"374","author":"BM Mayosi","year":"2009","journal-title":"The American journal of clinical nutrition"},{"issue":"2","key":"pone.0283645.ref045","doi-asserted-by":"crossref","first-page":"e0209756","DOI":"10.1371\/journal.pone.0209756","article-title":"Prevalence of non-communicable diseases (NCDs) and associated factors among HIV positive educators: Findings from the 2015\/6 survey of Health of Educators in Public Schools in South Africa.","volume":"14","author":"NP Zungu","year":"2019","journal-title":"PloS one."},{"issue":"9505","key":"pone.0283645.ref046","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0140-6736(06)67962-2","article-title":"Effects of routine prophylactic supplementation with iron and folic acid on admission to hospital and mortality in preschool children in a high malaria transmission setting: community-based, randomised, placebo-controlled trial","volume":"367","author":"S Sazawal","year":"2006","journal-title":"The Lancet"},{"key":"pone.0283645.ref047","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.srhc.2017.07.003","article-title":"The relationship between history of hormonal contraceptive use and iron status among women in Tanzania: A population-based study.","volume":"13","author":"ZT Haile","year":"2017","journal-title":"Sexual & Reproductive Healthcare."},{"issue":"3","key":"pone.0283645.ref048","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.contraception.2017.11.001","article-title":"Effect of oral contraception on anemia in 12 low-and middle-income countries.","volume":"97","author":"S Bellizzi","year":"2018","journal-title":"Contraception."},{"key":"pone.0283645.ref049","doi-asserted-by":"crossref","first-page":"631","DOI":"10.2147\/IJWH.S46680","article-title":"Menstrual suppression: current perspectives","volume":"6","author":"PA Hillard","year":"2014","journal-title":"International journal of women\u2019s health"},{"issue":"5","key":"pone.0283645.ref050","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/S0010-7824(98)00108-5","article-title":"Effects of contraceptives on hemoglobin and ferritin","volume":"58","author":"H Bathija","year":"1998","journal-title":"Contraception"},{"issue":"12","key":"pone.0283645.ref051","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1111\/tmi.12199","article-title":"Determinants of moderate\u2010to\u2010severe anaemia among women of reproductive age in T anzania: Analysis of data from the 2010 T anzania demographic and health survey","volume":"18","author":"C Wilunda","year":"2013","journal-title":"Tropical Medicine International Health"},{"issue":"1","key":"pone.0283645.ref052","doi-asserted-by":"crossref","first-page":"22","DOI":"10.4314\/ejhd.v25i1.69842","article-title":"Correlates of anemia among women of reproductive age in Ethiopia: evidence from Ethiopian DHS 2005","volume":"25","author":"S Gebremedhin","year":"2011","journal-title":"Ethiopian Journal of Health Development"},{"issue":"1","key":"pone.0283645.ref053","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1111\/nyas.12433","article-title":"Obesity and the nutrition transition in Sub\u2010Saharan Africa","volume":"1311","author":"NP Steyn","year":"2014","journal-title":"Annals of the New York academy of sciences"},{"issue":"10217","key":"pone.0283645.ref054","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0140-6736(19)32497-3","article-title":"Dynamics of the double burden of malnutrition and the changing nutrition reality","volume":"395","author":"BM Popkin","year":"2020","journal-title":"The Lancet"},{"issue":"3","key":"pone.0283645.ref055","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1038\/sj.ijo.0802804","article-title":"The nutrition transition: worldwide obesity dynamics and their determinants.","volume":"28","author":"BM Popkin","year":"2004","journal-title":"International journal of obesity"},{"issue":"2","key":"pone.0283645.ref056","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1079\/PNS19950018","article-title":"Interdependence of vitamin A and iron: an important association for programmes of anaemia control.","volume":"54","author":"MW Bloem","year":"1995","journal-title":"Proceedings of the nutrition society."},{"issue":"3","key":"pone.0283645.ref057","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1128\/CMR.18.3.446-464.2005","article-title":"Effects of vitamin A supplementation on immune responses and correlation with clinical outcomes","volume":"18","author":"E Villamor","year":"2005","journal-title":"Clinical microbiology reviews"},{"issue":"3","key":"pone.0283645.ref058","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1093\/ajcn\/84.3.580","article-title":"Vitamin A supplementation in children with poor vitamin A and iron status increases erythropoietin and hemoglobin concentrations without changing total body iron","volume":"84","author":"MB Zimmermann","year":"2006","journal-title":"The American journal of clinical nutrition"},{"issue":"Suppl. 1","key":"pone.0283645.ref059","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1159\/000345167","article-title":"Global nutrition epidemiology and trends","volume":"61","author":"ZA Bhutta","year":"2012","journal-title":"Annals of Nutrition Metabolism"},{"key":"pone.0283645.ref060","author":"World Health Organization","year":"2020","journal-title":"Global anaemia reduction efforts among women of reproductive age: impact, achievement of targets and the way forward for optimizing efforts."},{"issue":"6","key":"pone.0283645.ref061","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1093\/ajcn\/13.6.354","article-title":"Serum iron and iron-binding capacity in adolescents: II. Comparison of obese and nonobese subjects","volume":"13","author":"CC Seltzer","year":"1963","journal-title":"The American journal of clinical nutrition"},{"issue":"12","key":"pone.0283645.ref062","doi-asserted-by":"crossref","first-page":"2748","DOI":"10.1093\/ajcn\/34.12.2748","article-title":"Hemoglobin criteria with respect to obesity","volume":"34","author":"J Scheer","year":"1981","journal-title":"The American journal of clinical nutrition"},{"issue":"3","key":"pone.0283645.ref063","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1038\/sj.ijo.0802224","article-title":"Greater prevalence of iron deficiency in overweight and obese children and adolescents","volume":"27","author":"O Pinhas-Hamiel","year":"2003","journal-title":"International journal of obesity"},{"issue":"1","key":"pone.0283645.ref064","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1542\/peds.114.1.104","article-title":"Overweight children and adolescents: a risk group for iron deficiency","volume":"114","author":"KG Nead","year":"2004","journal-title":"Pediatrics"},{"issue":"8","key":"pone.0283645.ref065","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1002\/oby.20503","article-title":"Parity and body mass index in US women: a prospective 25\u2010year study.","volume":"21","author":"B Abrams","year":"2013","journal-title":"Obesity reviews."},{"issue":"2","key":"pone.0283645.ref066","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1046\/j.1467-789X.2002.00061.x","article-title":"Long\u2010term weight development after pregnancy","volume":"3","author":"Y Linn\u00e9","year":"2002","journal-title":"Obesity Reviews"},{"issue":"1","key":"pone.0283645.ref067","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1038\/sj.ejcn.1601502","article-title":"Associations between reproduction and maternal body weight: examining the component parts of a full reproductive cycle","volume":"57","author":"A Winkvist","year":"2003","journal-title":"European Journal of Clinical Nutrition"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0283645","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T10:50:59Z","timestamp":1729162259000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0283645"}},"subtitle":[],"editor":[{"given":"Bishwajit","family":"Ghose","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2023,3,30]]},"references-count":67,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2023,3,30]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0283645","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,30]]}}}