{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T22:38:35Z","timestamp":1793831915132,"version":"4.6.1"},"reference-count":30,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2023,4,13]],"date-time":"2023-04-13T00:00:00Z","timestamp":1681344000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["Finance Code 001"],"award-info":[{"award-number":["Finance Code 001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>This study aimed to evaluate the epidemiology and 30-day mortality of adult patients with methicillin-resistant <jats:italic>Staphylococcus aureus<\/jats:italic> (MRSA) bacteremia. We retrospectively reviewed the demographic and clinical data of adult patients with <jats:italic>S<\/jats:italic>. <jats:italic>aureus<\/jats:italic> bloodstream infections (BSI), admitted to a tertiary public teaching medical center in Porto Alegre, Southern Brazil, from January 2014 to December 2019. A total of 928 patients with <jats:italic>S<\/jats:italic>. <jats:italic>aureus<\/jats:italic> BSI were identified in the study period (68.5 per 100,000 patient-years), and the proportion of MRSA isolates was 22% (19\u201327%). Thus, 199 patients were included in the analyses. The median age was 62 (IQR: 51\u201374) years, Charlson Comorbidity Index (CCI) median was 5 (IQR: 3\u20136), the Pitt bacteremia score (PBS) median was 1 (IQR: 1\u20134), and the most common site of infection was skin and soft tissue (26%). Most infections were hospital-acquired (54%), empirical anti-MRSA treatment was initiated in 34% of the cases, and in 44% vancomycin minimum inhibitory concentration was 1.5mg\/L or above. Sixty-two (31.2%) patients died up to 30 days after the bacteremia episode. Patients with more comorbid conditions (higher CCI; aOR 1.222, p = 0.006) and a more severe presentation (higher PBS; aOR 1.726, p&lt;0.001) were independently associated with mortality. Empiric antimicrobial therapy with an anti-MRSA regimen was associated with reduced mortality (aOR 0.319, p = 0.016). Our study identified significant risk factors for 30-day mortality in patients with MRSA BSI in a population with a high incidence of <jats:italic>S<\/jats:italic>. <jats:italic>aureus<\/jats:italic> bacteremia. Empiric treatment with an anti-MRSA drug was a protective factor. No significant variation in the incidence of <jats:italic>S<\/jats:italic>. <jats:italic>aureus<\/jats:italic> BSI was recorded throughout the period.<\/jats:p>","DOI":"10.1371\/journal.pone.0283774","type":"journal-article","created":{"date-parts":[[2023,4,13]],"date-time":"2023-04-13T18:09:00Z","timestamp":1681409340000},"page":"e0283774","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":9,"title":["Epidemiology and risk factors for mortality among methicillin-resistant Staphylococcus aureus bacteremic patients in Southern Brazil"],"prefix":"10.1371","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1120-217X","authenticated-orcid":true,"given":"Cezar Vin\u00edcius W\u00fcrdig","family":"Riche","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renato","family":"Cassol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego Rodrigues","family":"Falci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4084-6233","authenticated-orcid":true,"given":"Mario","family":"Ramirez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8358-1183","authenticated-orcid":true,"given":"C\u00edcero Arm\u00eddio Gomes","family":"Dias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2023,4,13]]},"reference":[{"issue":"3","key":"pone.0283774.ref001","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1128\/CMR.00134-14","article-title":"Staphylococcus aureus infections: epidemiology, pathophysiology, clinical manifestations, and management","volume":"28","author":"SYC Tong","year":"2015","journal-title":"Clin Microbiol Rev"},{"issue":"2","key":"pone.0283774.ref002","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1128\/CMR.05022-11","article-title":"Predictors of mortality in Staphylococcus aureus Bacteremia","volume":"25","author":"SJ van Hal","year":"2012","journal-title":"Clin Microbiol Rev"},{"issue":"7","key":"pone.0283774.ref003","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.00355-19","article-title":"The Microbiology of Bloodstream Infection: 20-Year Trends from the SENTRY Antimicrobial Surveillance Program","volume":"63","author":"DJ Diekema","year":"2019","journal-title":"Antimicrob Agents Chemother"},{"issue":"2","key":"pone.0283774.ref004","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.cmi.2019.10.031","article-title":"Burden of bacterial bloodstream infection-a brief update on epidemiology and significance of multidrug-resistant pathogens","volume":"26","author":"WV Kern","year":"2020","journal-title":"Clin Microbiol Infect"},{"key":"pone.0283774.ref005","unstructured":"World Health Organization. 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