{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T04:20:08Z","timestamp":1747196408216,"version":"3.40.5"},"reference-count":46,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2023,3,31]],"date-time":"2023-03-31T00:00:00Z","timestamp":1680220800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R01CA186720"],"award-info":[{"award-number":["R01CA186720"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["TL1TR002735"],"award-info":[{"award-number":["TL1TR002735"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["UL1TR002733"],"award-info":[{"award-number":["UL1TR002733"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Objective<\/jats:title>\n<jats:p>Breast cancer survivors live longer due to more advanced cancer treatments; however, cardiovascular disease (CVD) is the leading non-cancer cause of death in breast cancer survivors. Previous studies have shown that depression is associated with an increased risk of CVD development. This study investigated whether depressive symptoms or mood disorder history, either independently or in combination with cardiotoxic treatments, predicted older cardiopulmonary age using a novel index\u2013the Age Based on Exercise Stress Test (ABEST)\u2013among breast cancer survivors.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>Breast cancer survivors (<jats:italic>N =<\/jats:italic> 80, ages 26\u201372, stage I-IIIA) were assessed an average of 53 days (<jats:italic>SD<\/jats:italic> = 26) post-surgery, but before adjuvant treatment, and again an average of 32 (<jats:italic>SD<\/jats:italic> = 6) months thereafter. At both visits, they reported depressive symptoms on the Center for Epidemiologic Studies Depression Scale (CES-D), completed the Structured Clinical Interview for DSM-V, and engaged in an exercise stress test to obtain ABEST scores.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>Controlling for treatment type, age, education, trunk fat, antidepressant use, and time between visits, longitudinal analyses showed that breast cancer survivors with a mood disorder history had worsening ABEST scores over time, compared to their peers without this history (p = .046). Change in physical activity between Visits 1 and 2 did not mediate this relationship (95% CI: -0.16\u20130.51). Ancillary analyses provided some additional support for the primary finding, such that those with a mood disorder history trended toward greater decreases in Vo<jats:sub>2<\/jats:sub>max, although results were marginally non-significant <jats:italic>(p =<\/jats:italic> .095). There were no cross-sectional relationships between depressive symptoms or mood disorder history and ABEST scores (<jats:italic>p<\/jats:italic>s&gt;.20). Treatment type did not modulate observed relationships (<jats:italic>ps&gt;<\/jats:italic>.22).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusions<\/jats:title>\n<jats:p>Breast cancer survivors with a mood disorder history may experience faster cardiopulmonary aging compared to their peers without such a history, raising risk for CVD.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0283849","type":"journal-article","created":{"date-parts":[[2023,3,31]],"date-time":"2023-03-31T17:56:36Z","timestamp":1680285396000},"page":"e0283849","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":1,"title":["A troubled heart: Mood disorder history longitudinally predicts faster cardiopulmonary aging in breast cancer survivorship"],"prefix":"10.1371","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6091-6844","authenticated-orcid":true,"given":"Annelise 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Guo","year":"2018","journal-title":"Cancer"},{"key":"pone.0283849.ref002","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1097\/EDE.0000000000000394","article-title":"Cardiovascular disease mortality among breast cancer survivors","volume":"27","author":"PT Bradshaw","year":"2016","journal-title":"Epidemiol Camb Mass"},{"key":"pone.0283849.ref003","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1097\/EDE.0000000000000394","article-title":"Cardiovascular Disease Mortality Among Breast Cancer Survivors.","volume":"27","author":"PT Bradshaw","year":"2016","journal-title":"Epidemiol Camb Mass"},{"key":"pone.0283849.ref004","first-page":"1","article-title":"Strategies to prevent anthracycline-induced cardiotoxicity in cancer survivors","volume":"5","author":"N Bansal","year":"2019","journal-title":"Cardio-Oncol"},{"key":"pone.0283849.ref005","doi-asserted-by":"crossref","first-page":"3777","DOI":"10.1200\/JCO.2007.14.9401","article-title":"Anthracycline cardiotoxicity: from 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index","volume":"40","author":"G-C Chen","year":"2019","journal-title":"Eur Heart J"},{"key":"pone.0283849.ref024","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.cger.2009.07.007","article-title":"The burden of cardiovascular disease in the elderly: morbidity, mortality, and costs.","volume":"25","author":"A Yazdanyar","year":"2009","journal-title":"Clin Geriatr Med"},{"key":"pone.0283849.ref025","doi-asserted-by":"crossref","first-page":"e005222","DOI":"10.1136\/bmjopen-2014-005222","article-title":"Association of socioeconomic status measured by education, and cardiovascular health: a population-based cross-sectional study","volume":"4","author":"S Jankovi\u0107","year":"2014","journal-title":"BMJ Open"},{"key":"pone.0283849.ref026","first-page":"141","article-title":"A simple method to assess exercise behavior in the community","volume":"10","author":"G Godin","year":"1985","journal-title":"Can J Appl Sport Sci"},{"key":"pone.0283849.ref027","first-page":"18","article-title":"The Godin-Shephard leisure-time physical activity questionnaire","volume":"4","author":"G. Godin","year":"2011","journal-title":"Health Fit J Can"},{"article-title":"PROCESS: A versatile computational tool for observed variable mediation, moderation, and conditional process modeling.","year":"2012","author":"AF Hayes","key":"pone.0283849.ref028"},{"key":"pone.0283849.ref029","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.bbi.2012.05.006","article-title":"Depressive symptoms enhance stress-induced inflammatory responses","volume":"31","author":"CP Fagundes","year":"2013","journal-title":"Brain Behav Immun"},{"key":"pone.0283849.ref030","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1097\/01.psy.0000174172.82428.ce","article-title":"Clinical depression and regulation of the inflammatory response during acute stress.","volume":"67","author":"GE Miller","year":"2005","journal-title":"Psychosom Med"},{"key":"pone.0283849.ref031","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1176\/ajp.2006.163.9.1630","article-title":"Increased stress-induced inflammatory responses in male patients with major depression and increased early life stress.","volume":"163","author":"TW Pace","year":"2006","journal-title":"Am J Psychiatry"},{"key":"pone.0283849.ref032","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1007\/s11920-011-0232-0","article-title":"Is depression an inflammatory disorder?","volume":"13","author":"CL Raison","year":"2011","journal-title":"Curr Psychiatry Rep"},{"key":"pone.0283849.ref033","doi-asserted-by":"crossref","first-page":"5995","DOI":"10.1073\/pnas.1118355109","article-title":"Chronic stress, glucocorticoid receptor resistance, inflammation, and disease risk","volume":"109","author":"S Cohen","year":"2012","journal-title":"Proc Natl Acad Sci"},{"key":"pone.0283849.ref034","doi-asserted-by":"crossref","first-page":"112802","DOI":"10.1016\/j.psychres.2020.112802","article-title":"Depression and cardiovascular disease: Shared molecular mechanisms and clinical implications.","volume":"285","author":"M Shao","year":"2020","journal-title":"Psychiatry Res."},{"key":"pone.0283849.ref035","doi-asserted-by":"crossref","first-page":"2508","DOI":"10.1001\/archinte.165.21.2508","article-title":"Depression and Medication Adherence in Outpatients With Coronary Heart Disease: Findings From the Heart and Soul Study","volume":"165","author":"A Gehi","year":"2005","journal-title":"Arch Intern Med"},{"key":"pone.0283849.ref036","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.amepre.2018.04.046","article-title":"Lifestyle indices and cardiovascular disease risk: a meta-analysis.","volume":"55","author":"J Barbaresko","year":"2018","journal-title":"Am J Prev Med"},{"key":"pone.0283849.ref037","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1037\/0022-006X.75.6.888","article-title":"Recovery from major depressive disorder among female adolescents: a prospective test of the scar hypothesis.","volume":"75","author":"CG Beevers","year":"2007","journal-title":"J Consult Clin Psychol"},{"key":"pone.0283849.ref038","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1037\/0021-843X.99.3.264","article-title":"Are people changed by the experience of having an episode of depression? 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