{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T01:17:21Z","timestamp":1778894241042,"version":"3.51.4"},"reference-count":34,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2023,4,7]],"date-time":"2023-04-07T00:00:00Z","timestamp":1680825600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Counsel of Technological and Scientific Development","award":["CNPq, Finance Code 001"],"award-info":[{"award-number":["CNPq, Finance Code 001"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\"><jats:title>Objective<\/jats:title><jats:p>To characterize the drug-related problems (DRPs) in high-risk pregnant women with hypertension and gestational diabetes mellitus according to frequency, type, cause, and factors associated with their occurrence in the hospital setting.<\/jats:p><\/jats:sec><jats:sec id=\"sec002\"><jats:title>Methodology<\/jats:title><jats:p>This is an observational, longitudinal, prospective study that included 571 hospitalized pregnant women with hypertension and gestational diabetes mellitus using at least one medication. DRPs were classified according to the<jats:italic>Classification for Drug-Related Problems<\/jats:italic>(PCNE V9.00). In addition to descriptive statistics, a univariate and multivariate logistic regression model was employed to determine the factors associated with the DRPs.<\/jats:p><\/jats:sec><jats:sec id=\"sec003\"><jats:title>Results<\/jats:title><jats:p>A total of 873 DRPs were identified. The most frequent DRPs were related to therapeutic ineffectiveness (72.2%) and occurrence of adverse events (27.0%) and the main drugs involved were insulins and methyldopa. These were followed in the first five days of treatment by: the ineffectiveness of insulin (24.6%), associated with underdosage (12.9%) or insufficient frequency of administration (9.5%) and methyldopa associated with the occurrence of adverse reactions (40.2%) in the first 48h. Lower maternal age (OR 0.966, 95% CI 0.938\u20130.995, p = 0.022), lower gestational age (OR 0.966, 95% CI 0.938\u20130.996, p = 0.026), report of drug hypersensitivity (OR 2.295, 95% CI 1.220\u20134.317, p = 0.010), longer treatment time (OR 1.237, 95% CI: 1.147\u20131.333, p = 0.001) and number of prescribed medications (OR 1.211, 95% CI: 0.240\u20135.476, p = 0.001) were risk factors for occurrence of DRPs.<\/jats:p><\/jats:sec><jats:sec id=\"sec004\"><jats:title>Conclusion<\/jats:title><jats:p>DRPs are frequent in pregnant women with hypertension and gestational diabetes mellitus, and they are mainly related to therapeutic ineffectiveness and the occurrence of adverse events.<\/jats:p><\/jats:sec>","DOI":"10.1371\/journal.pone.0284053","type":"journal-article","created":{"date-parts":[[2023,4,7]],"date-time":"2023-04-07T17:29:26Z","timestamp":1680888566000},"page":"e0284053","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":8,"title":["Drug-related problems in hypertension and gestational diabetes mellitus: A hospital cohort"],"prefix":"10.1371","volume":"18","author":[{"given":"Priscilla Karilline","family":"Vale Bezerra","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00e9ssica Escorel","family":"Chaves Cavalcanti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Solimar Ribeiro","family":"Carlete Filho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah Dantas Viana","family":"Medeiros","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio Gouveia","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9668-0482","authenticated-orcid":true,"given":"Rand Randall","family":"Martins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2023,4,7]]},"reference":[{"issue":"4","key":"pone.0284053.ref001","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/s10928-020-09677-1","article-title":"Anatomical and physiological alterations of pregnancy.","volume":"47","author":"JM Kazma","year":"2020","journal-title":"J Pharmacokinet Pharmacodyn"},{"issue":"10","key":"pone.0284053.ref002","first-page":"e18840","article-title":"The Association Between High Hemoglobin Levels and Pregnancy Complications, 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