{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T13:30:29Z","timestamp":1775827829406,"version":"3.50.1"},"reference-count":34,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2023,7,18]],"date-time":"2023-07-18T00:00:00Z","timestamp":1689638400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"International Association of Chinese Nephrologists scholarship"},{"DOI":"10.13039\/501100004853","name":"Chinese University of Hong Kong","doi-asserted-by":"publisher","award":["Richard Yu CUHK PD Research Fund"],"award-info":[{"award-number":["Richard Yu CUHK PD Research Fund"]}],"id":[{"id":"10.13039\/501100004853","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004853","name":"Chinese University of Hong Kong","doi-asserted-by":"publisher","award":["6905134 and 7105912"],"award-info":[{"award-number":["6905134 and 7105912"]}],"id":[{"id":"10.13039\/501100004853","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>The result of published studies on the clinical outcome of peritoneal dialysis (PD) after kidney allograft failure is conflicting. There are also few published data on the outcome of patients who had PD before kidney transplant and then return to PD after allograft failure.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>We reviewed 100 patients who were started on PD after kidney allograft failure between 2001 and 2020 (failed transplant group); 50 of them received PD before transplant. We compared the clinical outcome to 200 new PD patients matched for age, sex, and diabetic status (control group).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>The patients were followed for 45.8 \u00b1 40.5 months. the 2-year patient survival rate was 83.3% and 87.8% for the failed transplant and control groups, respectively (log rank test, p = 0.2). The corresponding 2-year technique survival rate 66.5% and 71.7% (p = 0.5). The failed transplant and control groups also had similar hospitalization rate and peritonitis rate. In the failed transplant group, there was also no difference in patient survival, technique survival, hospitalization, or peritonitis rate between those with and without PD before transplant. In the failed transplant group, patients who had PD before transplant and then returned to PD after allograft failure had substantial increase in D\/P4 (0.585 \u00b1 0.130 to 0.659 \u00b1 0.111, paired t-test, p = 0.032) and MTAC creatinine (7.74 \u00b1 3.68 to 9.73 \u00b1 3.00 ml\/min\/1.73m<jats:sup>2<\/jats:sup>, p = 0.047) from the time before the transplant to the time after PD was resumed after failed allograft.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusions<\/jats:title>\n<jats:p>The clinical outcome of PD patients with a failed kidney allograft is similar to other PD patients. However, patients who have a history of PD before kidney transplant and then return to PD after allograft failure have increased peritoneal transport parameters.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0284152","type":"journal-article","created":{"date-parts":[[2023,7,18]],"date-time":"2023-07-18T17:26:27Z","timestamp":1689701187000},"page":"e0284152","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":2,"title":["Peritoneal dialysis after failed kidney allograft: Comparing patients with and without pd before transplant"],"prefix":"10.1371","volume":"18","author":[{"given":"Na","family":"Tian","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han","family":"Meng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7676-7628","authenticated-orcid":true,"given":"Winston W. 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T.","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8898-8505","authenticated-orcid":true,"given":"Cheuk Chun","family":"Szeto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2023,7,18]]},"reference":[{"key":"pone.0284152.ref001","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/ki.1996.307","article-title":"A study of the quality of life and cost-utility of renal transplantation","volume":"50","author":"A Laupacis","year":"1996","journal-title":"Kidney Int"},{"key":"pone.0284152.ref002","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1007\/s40620-017-0379-9","article-title":"Infectious complications as the leading cause of death after kidney transplantation: analysis of more than 10,000 transplants from a single center","volume":"30","author":"F de Castro Rodrigues 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