{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T21:08:52Z","timestamp":1785445732413,"version":"3.56.0"},"reference-count":86,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2023,5,5]],"date-time":"2023-05-05T00:00:00Z","timestamp":1683244800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Objective<\/jats:title>\n<jats:p>Alcohol intake is a major risk factor for various diseases. Elucidating alcohol use disorder (AUD) is important in preventing diseases and promoting health. We aimed to investigate the effect of art therapy on emotional (Minnesota Multiphasic Personality Inventory-2 [MMPI-2]) and physical (natural killer [NK] cell count, expression of stress-associated proteins [SAP], and electroencephalography) changes in patients with AUD.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>Participants were randomly divided into two groups (n = 35), with the experimental group undergoing art therapy involving weekly 60-min group therapy sessions for 10 weeks. Statistical analysis was performed using Ranked ANCOVA and Wilcoxon\u2019s signed rank test. Western blotting was performed to analyze serum SAP levels.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>We observed an association between psychological mechanisms and stress proteins. There was an increased number of NK cells in the experimental group after the program. Moreover, compared with the control group, the experimental group showed significant changes in SAP expression. Further, the experimental group showed a positive change in the MMPI-2 profile, as well as a decrease in depression, anxiety, impulsivity, and alcohol dependence.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusions<\/jats:title>\n<jats:p>Continuous psychological support could be applied as a stress-control program for preventing stress recurrence and post-discharge relapse. Our findings strengthen the link between biomedical science and mental health in rehabilitation treatment for AUD.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0284344","type":"journal-article","created":{"date-parts":[[2023,5,5]],"date-time":"2023-05-05T17:34:23Z","timestamp":1683308063000},"page":"e0284344","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":8,"title":["A pilot randomized clinical trial of biomedical link with mental health in art therapy intervention programs for alcohol use disorder: Changes in NK cells, addiction biomarkers, electroencephalography, and MMPI-2 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Song","year":"2002","journal-title":"Goyang-si: Korean Drinking Culture Research Center;"},{"key":"pone.0284344.ref007","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1161\/CIRCULATIONAHA.110.943860","article-title":"Evaluating the clinical utility of a biomarker: A review of methods for estimating health impact","volume":"123","author":"MJ Pletcher","year":"2011","journal-title":"Circulation"},{"issue":"1","key":"pone.0284344.ref008","doi-asserted-by":"crossref","first-page":"48","DOI":"10.7586\/jkbns.2017.19.1.48","article-title":"Influence of severity of problem drinking, circadian rhythm and sleep quality on sleep disorder in alcohol use disorder patients","volume":"19","author":"SJ Ko","year":"2017","journal-title":"J Korean Biol Nurs Sci"},{"issue":"1","key":"pone.0284344.ref009","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1159\/000077944","article-title":"Pharmacodynamic effects of acamprosate on markers of cerebral function in alcohol-dependent subjects administered as pretreatment and during alcohol abstinence","volume":"50","author":"PH Boeijinga","year":"2004","journal-title":"Neuropsychobiology"},{"key":"pone.0284344.ref010","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.3389\/fpsyg.2017.01688","article-title":"Short-term beneficial effects of 12 sessions of neurofeedback on avoidant personality accentuation in the treatment of alcohol use disorder","volume":"8","author":"N Dalkner","year":"2017","journal-title":"Front Psychol"},{"issue":"5","key":"pone.0284344.ref011","first-page":"944","article-title":"Effects of alcohol on EEG, event related potential P300, and neurocognitive function in patients with alcohol dependence.","volume":"39","author":"SI Han","year":"2000","journal-title":"J Korean Neuropsychiatr Assoc."},{"key":"pone.0284344.ref012","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/BF01135562","article-title":"QEEG profiles of psychiatric disorders","volume":"4","author":"LS Prichep","year":"1992","journal-title":"Brain Topogr"},{"key":"pone.0284344.ref013","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1300\/J184v07n03_05","article-title":"Quantitative EEG normative databases: validation and clinical correlation.","volume":"7","author":"RW Thatcher","year":"2003","journal-title":"J Neurother"},{"key":"pone.0284344.ref014","volume-title":"Introduction to quantitative EEG and neurofeedback: advanced theory and applications","author":"RW Thatcher","year":"2009"},{"key":"pone.0284344.ref015","first-page":"225","article-title":"Basic electrophysiology of the electroencephalography.","volume":"21","author":"SB Hong","year":"2003","journal-title":"J Korean Neurol Assoc"},{"key":"pone.0284344.ref016","doi-asserted-by":"crossref","DOI":"10.1093\/med\/9780190228484.001.0001","volume-title":"Niedermeyer\u2019s electroencephalography: basic principles, clinical applications, and related fields.","author":"DS Schimer","year":"2017","edition":"7"},{"key":"pone.0284344.ref017","volume-title":"An introduction to field analysis techniques: the power spectrum and coherence [Internet]","author":"MA Kramer","year":"2013"},{"key":"pone.0284344.ref018","first-page":"851","article-title":"Diagnostic yield of routine EEG in adults with active epilepsy.","volume":"112","author":"R McGinty","year":"2019","journal-title":"Ir Med J"},{"issue":"4","key":"pone.0284344.ref019","doi-asserted-by":"crossref","first-page":"397","DOI":"10.15324\/kjcls.2019.51.4.397","article-title":"EEG recording method for quantitative analysis.","volume":"51","author":"JS Heo","year":"2019","journal-title":"Korean J Clin Lab Sci"},{"key":"pone.0284344.ref020","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0165-1781(97)00148-0","article-title":"Quantitative EEG (QEEG) predicts relapse in patients with chronic alcoholism and points to a frontally pronounced cerebral disturbance.","volume":"78","author":"G Winterer","year":"1998","journal-title":"Psychiatry Res."},{"key":"pone.0284344.ref021","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1111\/j.1530-0277.2003.tb04397.x","article-title":"Theta power in the EEG of alcoholics","volume":"27","author":"M Rangaswamy","year":"2003","journal-title":"Alcohol Clin Exp Res"},{"key":"pone.0284344.ref022","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/S0006-3223(02)01362-8","article-title":"Beta power in the EEG of alcoholics","volume":"52","author":"M Rangaswamy","year":"2002","journal-title":"Biol Psychiatry"},{"key":"pone.0284344.ref023","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1111\/j.1530-0277.1999.tb04352.x","article-title":"Association of low-voltage alpha EEG with a subtype of alcohol use disorders","volume":"23","author":"MA Enoch","year":"1999","journal-title":"Alcohol Clin Exp Res"},{"key":"pone.0284344.ref024","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.3389\/fpsyg.2017.01688","article-title":"Short-term beneficial effects of 12 sessions of neurofeedback on avoidant personality accentuation in the treatment of alcohol use disorder","volume":"8","author":"N Dalkner","year":"2017","journal-title":"Front Psychol"},{"key":"pone.0284344.ref025","volume-title":"In:Introduction to QEEG and neurofeedback.","author":"DL Trudeau","year":"2009"},{"issue":"4","key":"pone.0284344.ref026","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1016\/j.clinph.2005.12.021","article-title":"Clinical correlates of quantitative EEG alterations in alcoholic patients.","volume":"117","author":"P Coutin-Churchman","year":"2006","journal-title":"Clin Neurophysiol"},{"issue":"3","key":"pone.0284344.ref027","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/S0893-133X(01)00236-6","article-title":"Predicting relapse to alcohol and drug abuse via quantitative electroencephalography","volume":"25","author":"LO Bauer","year":"2001","journal-title":"Neuropsychopharmacology"},{"issue":"8","key":"pone.0284344.ref028","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/S0006-3223(02)01362-8","article-title":"Beta power in the EEG of alcoholics","volume":"52","author":"M Rangaswamy","year":"2002","journal-title":"Biol Psychiatry"},{"key":"pone.0284344.ref029","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1097\/01.alc.0000175013.50644.61","article-title":"Alcohol neurobiology: changes in dependence and recovery","volume":"29","author":"FT Crews","year":"2005","journal-title":"Alcohol Clin Exp Res"},{"key":"pone.0284344.ref030","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1159\/000147469","article-title":"Personality traits predict treatment outcome in alcohol-dependent patients.","volume":"57","author":"SE M\u00fcller","year":"2008","journal-title":"Neuropsychobiology."},{"issue":"4","key":"pone.0284344.ref031","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1111\/j.1465-3362.2011.00407.x","article-title":"Neurocognitive parameters should be incorporated in the Minnesota Multiphasic Personality Inventory-2 assessment of patients with alcohol use disorders","volume":"31","author":"SJW Walvoort","year":"2012","journal-title":"Drug Alcohol Rev"},{"key":"pone.0284344.ref032","volume-title":"MMPI-2 assessing personality and psychopathology, 4th edn.","author":"JR Graham","year":"2006"},{"issue":"4","key":"pone.0284344.ref033","first-page":"452","article-title":"The personality characteristics of the alcoholic patient.","volume":"23","author":"SN Cho","year":"1984","journal-title":"Psychiatry Investig"},{"key":"pone.0284344.ref034","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1037\/0022-006X.49.1.1","article-title":"Differences in measures of personality and family environment among black and white alcoholics.","volume":"49","author":"ET Patterson","year":"1981","journal-title":"J Consult Clin Psychol"},{"key":"pone.0284344.ref035","doi-asserted-by":"crossref","first-page":"357","DOI":"10.15288\/jsa.1980.41.357","article-title":"\u201cIndianism\u201d and MMPI scores on men alcoholics.","volume":"41","author":"AE Uecker","year":"1980","journal-title":"J Stud Alcohol"},{"issue":"2","key":"pone.0284344.ref036","first-page":"142","article-title":"Exploration of personality trait in alcoholics.","volume":"8","author":"HJ Yoon","year":"2004","journal-title":"J Korean Acad Addict Psychiatry"},{"key":"pone.0284344.ref037","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1037\/1040-3590.15.4.521","article-title":"Treatment utility of psychological assessment.","volume":"15","author":"RO Nelson-Gray","year":"2003","journal-title":"Psychol Assess"},{"key":"pone.0284344.ref038","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1146\/annurev.clinpsy.1.102803.144107","article-title":"The development of alcohol use disorders","volume":"1","author":"KJ Sher","year":"2005","journal-title":"Annu Rev Clin Psychol"},{"key":"pone.0284344.ref039","unstructured":"American Art Therapy Association. Available online: https:\/\/arttherapy.org\/about-art-therapy\/ (accessed on 7 March 2023)."},{"key":"pone.0284344.ref040","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0090-9092(73)90009-4","article-title":"Art therapy for the drug addict","volume":"1","author":"E. Harms","year":"1973","journal-title":"Arts Psychother"},{"issue":"4","key":"pone.0284344.ref041","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/0197-4556(83)90026-6","article-title":"Art therapy with substance abusers: A review of the literature.","volume":"10","author":"RW Moore","year":"1983","journal-title":"Arts Psychother"},{"key":"pone.0284344.ref042","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/0197-4556(90)90049-V","article-title":"Creative therapies in the treatment of addictions: The art of transforming shame","volume":"17","author":"L. Johnson","year":"1990","journal-title":"Arts Psychother."},{"issue":"4","key":"pone.0284344.ref043","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/0197-4556(90)90053-S","article-title":"Breaking through: Incident drawings with adolescent substance abusers.","volume":"17","author":"KL Cox","year":"1990","journal-title":"Arts Psychother"},{"issue":"4","key":"pone.0284344.ref044","first-page":"110","article-title":"Increasing chemically dependent patients\u2019 belief in step one through expressive therapy","volume":"33","author":"K. Julliard","year":"1995","journal-title":"Am J Art Ther"},{"key":"pone.0284344.ref045","first-page":"64","article-title":"Group art therapy with day-hospital schizophrenic patients.","volume":"7","author":"HH Jung","year":"2007","journal-title":"Korean J Art Ther"},{"key":"pone.0284344.ref046","first-page":"821","article-title":"The effect of group art therapy affects on single mother\u2019s self\u2014esteem, depressions, and anxieties.","volume":"12","author":"HS Kim","year":"2005","journal-title":"Korean J Art Ther"},{"key":"pone.0284344.ref047","first-page":"51","article-title":"The effect of group art therapy on self-esteem and interpersonal relations adequacy of homeless alcoholics.","volume":"11","author":"KS Kim","year":"2004","journal-title":"Korean J Art Ther"},{"key":"pone.0284344.ref048","unstructured":"Choi JH. A study on the level of daily life satisfaction in wives of alcoholics. Master\u2019s Thesis. Daegu, Republic of Korea: Department of Social Welfare Graduate School. Daegu University; 1993."},{"key":"pone.0284344.ref049","first-page":"231","article-title":"The effect of art therapy on self-esteem and emotional stability of alcoholic.","volume":"10","author":"OK Ryu","year":"2003","journal-title":"Korean J Art Ther"},{"key":"pone.0284344.ref050","volume-title":"Inner vision: An exploration of art and the brain","author":"S Zeki","year":"1999"},{"key":"pone.0284344.ref051","volume-title":"Art therapy and neuroscience of relationships,creativity and resiliency: Skills and practices.","author":"N Hass-Cohen","year":"2015"},{"issue":"3","key":"pone.0284344.ref052","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1080\/07421656.2004.10129496","article-title":"Art Therapy and Brain: An attempt to understand the underlying processes of art expression in therapy","volume":"21","author":"VB Lusebrink","year":"2004","journal-title":"Art Ther"},{"issue":"2","key":"pone.0284344.ref053","doi-asserted-by":"crossref","first-page":"497","DOI":"10.35594\/kata.2010.17.2.015","article-title":"Neuro-scientific contemplation on artistic expression of art therapy.","volume":"17","author":"YH Park","year":"2010","journal-title":"Korean J Art Ther"},{"issue":"2","key":"pone.0284344.ref054","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1080\/07421656.2008.10129412","article-title":"Conducting art therapy research using quantitative EEG measures.","volume":"25","author":"CM Belkofer","year":"2008","journal-title":"Art Ther."},{"issue":"2","key":"pone.0284344.ref055","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1080\/07421656.2014.903821","article-title":"Effects of drawing on alpha activity: A quantitative EEG study with implications for art therapy.","volume":"31","author":"CM Belkofer","year":"2014","journal-title":"Art Ther."},{"key":"pone.0284344.ref056","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.aip.2017.05.004","article-title":"Functional near-infrared spectroscopy assessment of reward perception based on visual self-expression: Coloring, doodling, and free drawing.","volume":"55","author":"G Kaimal","year":"2017","journal-title":"Arts Psychother."},{"key":"pone.0284344.ref057","volume-title":"Handbook of Survey Research.","author":"PB Sheatsley","year":"1983"},{"key":"pone.0284344.ref058","volume-title":"Handbook of Survey Research.","author":"S. Sudman","year":"1983"},{"issue":"5","key":"pone.0284344.ref059","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1111\/j.1752-8062.2011.00347.x","article-title":"Recommendations for planning pilot studies in clinical and translational research.","volume":"4","author":"CG Moore","year":"2011","journal-title":"Clin Transl Sci"},{"key":"pone.0284344.ref060","doi-asserted-by":"crossref","first-page":"7948","DOI":"10.1038\/sj.onc.1203362","article-title":"activation induces phosphorylation of Elk-1 at multiple S\/T-P motifs to high stoichiometry","volume":"18","author":"FH Cruzalegui","year":"1999","journal-title":"Oncogene"},{"key":"pone.0284344.ref061","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1074\/jbc.273.3.1741","article-title":"Selective activation of p38 mitogen-activated protein (MAP) kinase isoforms by the MAP kinase kinases MKK3 and MKK6.","volume":"273","author":"H Enslen","year":"1998","journal-title":"J Biol Chem"},{"key":"pone.0284344.ref062","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1126\/science.7618106","article-title":"Integration of MAP kinase signal transduction pathways at the serum response element","volume":"269","author":"AJ Whitmarsh","year":"1995","journal-title":"Science"},{"issue":"6","key":"pone.0284344.ref063","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1038\/sj.bjp.0705345","article-title":"Role of c-jun N-terminal kinase in the induced release of GM-CSF, RANTES and IL-8 from human airway smooth muscle cells.","volume":"139","author":"U Oltmanns","year":"2003","journal-title":"Br J Pharmacol"},{"issue":"8","key":"pone.0284344.ref064","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1023\/B:BIRY.0000040215.02460.45","article-title":"JNK: a key modulator of intracellular signaling.","volume":"69","author":"S Vlahopoulos","year":"2004","journal-title":"Biochem (Mosc)."},{"key":"pone.0284344.ref065","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/BF01712768","article-title":"Evaluation of the effectiveness of EEG neurofeedback training for ADHD in a clinical setting as measured by changes in T.O.V.A. scores behavioral rating, and WISC-R performance.","volume":"20","author":"JF Lubar","year":"1995","journal-title":"Biofeedback Self Regul."},{"key":"pone.0284344.ref066","volume-title":"Interpretation method of EEG.","author":"PW Park","year":"2005"},{"issue":"2","key":"pone.0284344.ref067","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1037\/0022-3514.67.2.319","article-title":"Behavioral inhibition, behavioral activation, and affective responses to impending reward and punishment: The BIS\/BAS Scales.","volume":"67","author":"CS Carver","year":"1994","journal-title":"J Pers Soc Psychol"},{"key":"pone.0284344.ref068","volume-title":"The Minnesota multiphasic personality inventory, Rev.","author":"SR Hathaway","year":"1943"},{"issue":"3","key":"pone.0284344.ref069","first-page":"569","article-title":"The preliminary study of the Korean alcoholism screening test (III).","volume":"30","author":"KB Kim","year":"1991","journal-title":"J Korean Neuropsychiatr Assoc"},{"key":"pone.0284344.ref070","first-page":"381","article-title":"Diagnostic validity of the CES-D (Korean Version) in the assessment of DSM-III-R major depression.","volume":"32","author":"MJ Cho","year":"1993","journal-title":"J Korean Neuropsychiatr Assoc"},{"key":"pone.0284344.ref071","volume-title":"Anxiety disorders and phobias: A cognitive approach","author":"A Beck","year":"1985"},{"key":"pone.0284344.ref072","first-page":"768","article-title":"Barratt impulsiveness scale.","volume":"51","author":"ES Barratt","year":"1959","journal-title":"J Clin Psychol"},{"key":"pone.0284344.ref073","volume-title":"Conduct impulsiveness test.,","author":"HS Lee","year":"1994"},{"issue":"3","key":"pone.0284344.ref074","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/0167-8760(95)00012-H","article-title":"Temporal stability of acute stressor-induced changes in cellular immunity","volume":"19","author":"PJ Mills","year":"1995","journal-title":"Int J Psychophysiol"},{"issue":"5","key":"pone.0284344.ref075","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1097\/00006842-199009000-00003","article-title":"Slow-reacting immunoglobulin in relation to social support and changes in job strain: a preliminary note.","volume":"52","author":"T Theorell","year":"1990","journal-title":"Psychosom Med"},{"issue":"3","key":"pone.0284344.ref076","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1097\/00006842-199405000-00007","article-title":"Influence of life stress on immunological reactivity to mild psychological stress.","volume":"56","author":"JF Brosschot","year":"1994","journal-title":"Psychosom Med."},{"key":"pone.0284344.ref077","first-page":"1","article-title":"Elk-1 a transcription factor with multiple facets in the brain","volume":"5","author":"B Galan","year":"2011","journal-title":"Front Neurosc"},{"issue":"2","key":"pone.0284344.ref078","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/S0033-3182(89)72294-5","article-title":"The brain and the immune system: A psychosomatic network","volume":"30","author":"EG Camara","year":"1989","journal-title":"Psychosomatics"},{"key":"pone.0284344.ref079","first-page":"79","article-title":"Analysis of the researches on stress and immune responses.","volume":"4","author":"YR Chae","year":"2002","journal-title":"J Korean Neuropsychiatr Assoc"},{"key":"pone.0284344.ref080","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/BF01000016","article-title":"Discourse on the development of EEG diagnostics and biofeedback for attention-deficit\/hyperactivity disorders","volume":"16","author":"JF Lubar","year":"1991","journal-title":"Biofeedback Self Regul"},{"key":"pone.0284344.ref081","first-page":"63","article-title":"Sensorimotor EEG operand conditioning and experimental and clinical effects.","volume":"12","author":"MB Sterman","year":"1977","journal-title":"Integr Psychol Behav Sci."},{"key":"pone.0284344.ref082","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1080\/02699939008410799","article-title":"Brain systems that mediate both emotion and cognition. Special issue: Development of relationsgips between emotion and cognition","volume":"4","author":"JA Gray","year":"1990","journal-title":"Cogn Emot"},{"key":"pone.0284344.ref083","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1080\/026999398379673","article-title":"Frontal EEG alpha asymmetry, depression, and cognitive functioning.","volume":"12","author":"IH Gotlib","year":"1998","journal-title":"Cogn Emot."},{"issue":"1","key":"pone.0284344.ref084","first-page":"125","article-title":"Neuroplasticity in human alcoholism: Studies of extended abstinence with potential treatment implications","volume":"37","author":"G Fein","year":"2015","journal-title":"Alcohol Res"},{"issue":"8","key":"pone.0284344.ref085","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.1111\/acer.13779","article-title":"A combination of impulsivity subdomains predict alcohol intoxication frequency","volume":"42","author":"L O\u2019halloran","year":"2018","journal-title":"Alcohol Clin Exp Res"},{"issue":"8","key":"pone.0284344.ref086","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1111\/acer.13802","article-title":"Emotion recognition biases in alcohol use disorder","volume":"42","author":"CR Freeman","year":"2018","journal-title":"Alcohol Clin Exp Res"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0284344","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,5]],"date-time":"2023-05-05T17:35:53Z","timestamp":1683308153000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0284344"}},"subtitle":[],"editor":[{"given":"Meera","family":"Rastogi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2023,5,5]]},"references-count":86,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2023,5,5]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0284344","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,5]]}}}