{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T16:36:01Z","timestamp":1792427761882,"version":"4.5.0"},"reference-count":50,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2023,4,13]],"date-time":"2023-04-13T00:00:00Z","timestamp":1681344000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>Chronic atrophic gastritis is a significant premalignant lesion of gastric carcinoma. There is a great need to prevent the progression to gastric carcinoma through early intervention and treatment for chronic atrophic gastritis. Weifuchun, a famous Chinese patent drug, has been widely used for chronic atrophic gastritis in China. However, it remains unclear whether Weifuchun is effective for atrophic gastritis.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Objective<\/jats:title>\n<jats:p>To determine the effectiveness and safety of Weifuchun for chronic atrophic gastritis.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Methods<\/jats:title>\n<jats:p>We systematically retrieved seven databases (Cochrane Library, EMBASE, PubMed, China National Knowledge Infrastructure, Wanfang database, Chinese Scientific Journals Database, and Chinese Biological Medical Database) from their inception to October 5, 2022. Methodological quality was examined using the Cochrane Risk of bias tool. We also used RevMan 5.4 software for statistical analysis to examine the effectiveness and safety of Weifuchun.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Results<\/jats:title>\n<jats:p>Fifteen studies with 1,488 patients were enrolled in this meta-analysis. The study indicated that Weifuchun was more effective (RR 1.52; 95% CI 1.41, 1.63; p&lt;0.00001) than Western medicine and other Chinese patent medicine. In addition, Weifuchun was more effective in improving gastric mucosal under gastroscopy, improving histopathologic changes of gastric mucosal, and inhibiting Helicobacter pylori. However, no significant difference in safety was examined between Weifuchun and the control group (RR 2.83; 95% CI 0.85, 9.38; P = 0.09).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec005\">\n<jats:title>Conclusions<\/jats:title>\n<jats:p>The meta-analysis revealed a significant statistical difference with Weifuchun in effectiveness compared to the control group. However, there was no significant difference in safety. Thus, more high-quality clinical studies are needed in the future.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec006\">\n<jats:title>Trial registration<\/jats:title>\n<jats:p>Registration number <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.crd.york.ac.uk\/prospero\/display_record.php?ID=CRD42022365703\" xlink:type=\"simple\">CRD42022365703<\/jats:ext-link>.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0284411","type":"journal-article","created":{"date-parts":[[2023,4,13]],"date-time":"2023-04-13T18:14:44Z","timestamp":1681409684000},"page":"e0284411","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":20,"title":["Efficacy and safety of Weifuchun tablet for chronic atrophic gastritis: A systematic review and meta-analysis"],"prefix":"10.1371","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5200-6303","authenticated-orcid":true,"given":"Longhua","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuwen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuying","family":"Ru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fenglei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2023,4,13]]},"reference":[{"issue":"3","key":"pone.0284411.ref001","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries.","volume":"71","author":"H Sung","year":"2021","journal-title":"CA Cancer J Clin."},{"issue":"6","key":"pone.0284411.ref002","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1007\/s10120-022-01317-6","article-title":"A retrospective 5-year survival analysis of surgically resected gastric cancer cases from the Japanese Gastric Cancer Association nationwide registry (2001\u20132013).","volume":"25","author":"Y Kakeji","year":"2022","journal-title":"Gastric Cancer."},{"issue":"1","key":"pone.0284411.ref003","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1097\/00008469-200102000-00013","article-title":"Current thoughts on the histopathogenesis of gastric cancer","volume":"10","author":"F Carneiro","year":"2001","journal-title":"Eur J Cancer Prev"},{"issue":"24","key":"pone.0284411.ref004","first-page":"6735","article-title":"Human gastric carcinogenesis: a multistep and multifactorial process\u2014First American Cancer Society Award Lecture on Cancer Epidemiology and Prevention","volume":"52","author":"P. Correa","year":"1992","journal-title":"Cancer Res"},{"issue":"5 Suppl","key":"pone.0284411.ref005","doi-asserted-by":"crossref","first-page":"S29","DOI":"10.1097\/00004836-200305001-00006","article-title":"Gastric atrophy, metaplasia, and dysplasia: a clinical perspective.","volume":"36","author":"CR Kapadia","year":"2003","journal-title":"J Clin Gastroenterol"},{"issue":"1","key":"pone.0284411.ref006","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1055\/s-0031-1291491","article-title":"Management of precancerous conditions and lesions in the stomach (MAPS): guideline from the European Society of Gastrointestinal Endoscopy (ESGE), European Helicobacter Study Group (EHSG), European Society of Pathology (ESP), and the Sociedade Portuguesa de Endoscopia Digestiva (SPED).","volume":"44","author":"M 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Pimentel-Nunes","year":"2019","journal-title":"Endoscopy."},{"issue":"8","key":"pone.0284411.ref012","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1136\/gut.2009.192757","article-title":"Helicobacter pylori treatment in the era of increasing antibiotic resistance","volume":"59","author":"DY Graham","year":"2010","journal-title":"Gut"},{"issue":"19","key":"pone.0284411.ref013","doi-asserted-by":"crossref","first-page":"5903","DOI":"10.3748\/wjg.v20.i19.5903","article-title":"Histological changes of gastric mucosa after Helicobacter pylori eradication: a systematic review and meta-analysis","volume":"20","author":"YJ Kong","year":"2014","journal-title":"World J Gastroenterol"},{"issue":"35","key":"pone.0284411.ref014","doi-asserted-by":"crossref","first-page":"e17003","DOI":"10.1097\/MD.0000000000017003","article-title":"Efficacy and safety of acupuncture therapy for chronic atrophic gastritis: A meta-analysis and trial sequential analysis protocol.","volume":"98","author":"Y Li","year":"2019","journal-title":"Medicine (Baltimore)."},{"issue":"7","key":"pone.0284411.ref015","doi-asserted-by":"crossref","first-page":"e0181906","DOI":"10.1371\/journal.pone.0181906","article-title":"The efficacy of Jianpi Yiqi therapy for chronic atrophic gastritis: A systematic review and meta-analysis.","volume":"12","author":"YK Dai","year":"2017","journal-title":"PLoS One"},{"issue":"09","key":"pone.0284411.ref016","first-page":"77","article-title":"Clinical application and modern research progress of Weifuchun","volume":"47","author":"X Chen","year":"2016","journal-title":"Jiangxi J Tradi Chin Med"},{"issue":"33","key":"pone.0284411.ref017","doi-asserted-by":"crossref","first-page":"5389","DOI":"10.3748\/wjg.v12.i33.5389","article-title":"Treatment of gastric precancerous lesions with Weiansan","volume":"12","author":"HZ Li","year":"2006","journal-title":"World J 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of Weifuchun tablets for chronic atrophic gastritis.","volume":"13","author":"HM Wu","year":"2000","journal-title":"Chin J Factory and Mining Med"},{"issue":"11","key":"pone.0284411.ref022","first-page":"686","article-title":"Weifuchun tablets for treating 50 cases of chronic atrophic gastritis.","volume":"20","author":"NG Zhu","year":"2001","journal-title":"J Her Med"},{"issue":"04","key":"pone.0284411.ref023","first-page":"31","article-title":"Weifuchun for treating 40 cases of chronic atrophic gastritis.","volume":"34","author":"F. Wang","year":"2003","journal-title":"Fujian J Tradi Chin Med"},{"issue":"32","key":"pone.0284411.ref024","first-page":"15","article-title":"Weifuchun tablets for treating 58 cases of chronic atrophic gastritis.","volume":"43","author":"JY Zhao","year":"2003","journal-title":"Shangdong J Med"},{"issue":"02","key":"pone.0284411.ref025","first-page":"95","article-title":"Clinical observation of Weifuchun for dysplasia of gastric mucosal and its regulatory effect of expression in p21ras and p53 protein.","volume":"12","author":"YG Zhang","year":"2004","journal-title":"Chin J Integr Trad West Med Dig"},{"issue":"08","key":"pone.0284411.ref026","first-page":"70","article-title":"Weifuchun for treating 144 cases of precancerous lesions of chronic atrophic gastritis.","volume":"13","author":"H Zhao","year":"2004","journal-title":"Chin J Clin Pharm"},{"issue":"01","key":"pone.0284411.ref027","first-page":"13","article-title":"Effect on histopathological changes of gastric mucosa of Weifuchun for atrophic gastritis.","volume":"24","author":"LL Yang","year":"2006","journal-title":"Xinjiang J Tradi Chin Med"},{"issue":"8","key":"pone.0284411.ref028","first-page":"39","article-title":"Weifuchun tablets for treating 152 cases of chronic atrophic gastritis.","volume":"23","author":"YQ Lei","year":"2010","journal-title":"Gansu J Tradi Chin Med"},{"issue":"6","key":"pone.0284411.ref029","first-page":"286","article-title":"Clinical observation of Weifuchun for precancerous lesions of chronic atrophic gastritis.","volume":"20","author":"H. 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Gu","year":"2016","journal-title":"Chin J Psychological Doctor"},{"issue":"11","key":"pone.0284411.ref031","first-page":"49","article-title":"Study of the correlation between the course treatment with the effectiveness of Weifuchun for chronic atrophic gastritis.","volume":"36","author":"LL Yuan","year":"2016","journal-title":"J Clin Med."},{"issue":"25","key":"pone.0284411.ref032","first-page":"33","article-title":"Clinical observation of Weifuchun for precancerous lesions of chronic atrophic gastritis.","volume":"24","author":"SL Kong","year":"2018","journal-title":"Chin J Psychological Doctor"},{"issue":"8","key":"pone.0284411.ref033","first-page":"38","article-title":"Clinical observation of Weifuchun for chronic atrophic gastritis with intestinal metaplasia.","volume":"11","author":"XF Xu","year":"2018","journal-title":"Chin J Clin Rational Drug Use"},{"issue":"1","key":"pone.0284411.ref034","article-title":"A correlational study of Weifuchun and its clinical effect on intestinal flora in precancerous lesions of gastric cancer","volume":"16","author":"Y Bian","year":"2021","journal-title":"Chinese medicine (united kingdom)."},{"issue":"11","key":"pone.0284411.ref035","first-page":"1983","article-title":"Clinical observation of Weifuchun capsule for atrophic gastritis with intestinal metaplasia.","volume":"37","author":"HR Wang","year":"2022","journal-title":"J Guangming Chin Med"},{"issue":"5","key":"pone.0284411.ref036","first-page":"617","article-title":"Efficacy of Weifuchun combined with Teprenone for chronic atrophic gastritis.","volume":"36","author":"LJ Cao","year":"2008","journal-title":"J Nanhua Uni (Med Sci)."},{"issue":"01","key":"pone.0284411.ref037","first-page":"11","article-title":"Treatment of Weifuchun for chronic atrophic gastritis: A meta-analysis.","volume":"42","author":"WL Liao","year":"2015","journal-title":"Liaoning J Tradi Chin Med"},{"issue":"2","key":"pone.0284411.ref038","first-page":"86","article-title":"Effectiveness of Weifuchun for precancerous lesions of gastric cancer","volume":"28","author":"L Lu","year":"2010","journal-title":"J Henan Univ Sci Tech"},{"issue":"02","key":"pone.0284411.ref039","first-page":"90","article-title":"Efficacy of Weifuchun combined with Retinoic acid for gastric precancerous lesions and its effect on expression of Rb Gene and C-erb B-2 Gene.","volume":"33","author":"XL Su","year":"2015","journal-title":"J Henan Univ Sci Tech (Med Sci)."},{"issue":"11","key":"pone.0284411.ref040","first-page":"768","article-title":"Prognosis of gastric precancerous lesions treated by Weifuchun combined with folic acid after eradication of Helicobacter pylori","volume":"23","author":"YQ Zhang","year":"2015","journal-title":"Chin J Integr Trad West Med Dig"},{"issue":"01","key":"pone.0284411.ref041","first-page":"81","article-title":"Weifuchun for chronic atrophic gastritis: A systematic review.","volume":"9","author":"LL Zhu","year":"2009","journal-title":"Chin J Evid-based 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expression in chronic gastritis with mucosal dysplasia.","volume":"31","author":"SJ Cui","year":"2013","journal-title":"J Henan Univ Sci Tech (Med Sci)."},{"issue":"02","key":"pone.0284411.ref046","first-page":"123","article-title":"Gene reversal mechanism of Weifuchun combined with colloidal bismuth pectin on patients with precancerous lesion of gastric carcinoma","volume":"32","author":"B Zheng","year":"2016","journal-title":"Chin J Clin Pharmacal"},{"issue":"04","key":"pone.0284411.ref047","first-page":"450","article-title":"Effect of Weifuchun on inhibiting inflammation of helicobacter pylori-infected GES-1 cells and NF-kappaB signaling pathway.","volume":"34","author":"X Huang","year":"2014","journal-title":"Chin J Integr Med."},{"issue":"07","key":"pone.0284411.ref048","first-page":"907","article-title":"Experimental study on the inhibitory effect of Weifuchun Tablets for Helicobacter pylori","volume":"10","author":"Y Chen","year":"2008","journal-title":"Zhejiang Clin Med"},{"issue":"02","key":"pone.0284411.ref049","first-page":"44","article-title":"Clinical observation and mechanism of Weifuchun in treating gastric intestinal metaplasia.","volume":"51","author":"XY Liu","year":"2017","journal-title":"Shanghai J Tradi Chin Med."},{"issue":"10","key":"pone.0284411.ref050","first-page":"1959","article-title":"Mechanism of Weifuchun tablets in treating chronic atrophic gastritis based on network pharmacology and molecular docking and in vitro cell experiment verification","volume":"45","author":"XQ Jiang","year":"2022","journal-title":"Drug Evaluation Research"}],"container-title":["PLOS 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