{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T05:58:20Z","timestamp":1787205500927,"version":"build-2736575974"},"reference-count":24,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2023,4,20]],"date-time":"2023-04-20T00:00:00Z","timestamp":1681948800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Introduction<\/jats:title>\n<jats:p>The risk for sudden cardiac death (SCD) increases with ageing.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>We evaluated causes and characteristics of unexpected SCD in SCD victims aged \u2265 80 years in a consecutive series of 5,869 SCD victims in Northern Finland. All the victims underwent medico-legal autopsy as medico-legal autopsy is mandatory in cases of unexpected sudden death in Finland. All the non-cardiac deaths such as pulmonary embolism and cerebral hemorrhage were excluded from the study, as were unnatural deaths such as intoxications.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>Among SCD victims \u2265 80 years, 91.0% of SCDs were due to ischemic heart disease (IHD) determined in autopsy and 9.0% due to non-ischemic heart disease (NIHD), whereas among those &lt; 80 years, only 72.6% of SCDs were due to IHD and 27.4% due to NIHD (P &lt; .001). Severe fibrosis in myocardium was more common whereas heart weight and liver weight, body mass index and abdominal fat thickness, were lower among SCD victims aged \u2265 80 years than among victims aged &lt; 80 years. In those with IHD as etiology of SCD, at least 75% stenosis in one or more major coronary vessels was more common in SCD victims aged \u2265 80 years than among victims aged &lt; 80 years (P = .001). SCD victims 80 years or older were less likely to die during physical activity than those under 80 years old (5.6% vs. 15.9%, P &lt; .001). Dying in sauna was more common among those \u2265 80 years than among those &lt; 80 years (5.5% vs. 2.6%, P &lt; .001).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>In victims of unexpected SCD aged \u2265 80 years, the autopsy-based etiology of SCD was more commonly IHD than in those aged &lt; 80 years. In SCD victims aged \u2265 80 years, severe fibrosis in myocardium, representing arrhythmic substrate, was more common than in the younger ones.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0284515","type":"journal-article","created":{"date-parts":[[2023,4,20]],"date-time":"2023-04-20T18:41:37Z","timestamp":1682016097000},"page":"e0284515","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":11,"title":["Causes and characteristics of unexpected sudden cardiac death in octogenarians\/nonagenarians"],"prefix":"10.1371","volume":"18","author":[{"given":"Elisa","family":"Puolitaival","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juha","family":"V\u00e4h\u00e4talo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauri","family":"Holmstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Anette E.","family":"Haukilahti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3494-7652","authenticated-orcid":true,"given":"Lasse","family":"Pakanen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olavi H.","family":"Ukkola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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