{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T13:11:55Z","timestamp":1780060315042,"version":"3.54.0"},"reference-count":53,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2023,4,20]],"date-time":"2023-04-20T00:00:00Z","timestamp":1681948800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010724","name":"Health Systems Research Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010724","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>This study evaluated prenatal screening test performance and the prevalence of common aneuploidies at Siriraj Hospital, Thailand. We collected data from screening tests which are first-trimester test, quadruple test, and noninvasive prenatal tests (NIPT) between January 2016 and December 2020. Thirty percent (7,860\/25,736) of pregnancies received prenatal screening tests for aneuploidies disorders, and 17.8% underwent prenatal diagnosis tests without screening. The highest percentage of screening tests was first-trimester test (64.5%). The high-risk results were 4% for first-trimester test, 6.6% for quadruple test, and 1.3% for NIPT. The serum screening tests for trisomy 13 and 18 had no true positives; therefore, we could not calculate sensitivity. For the first-trimester test, the sensitivity for trisomy 21 was 71.4% (95% confidence intervals (CI) 30.3\u201394.9); specificity for trisomy 13 and 18 was 99.9% (95% CI 99.8\u201399.9); and for trisomy 21 was 96.1% (95% CI 95.6\u201396.7). For the quadruple test, the specificity for trisomy 18 was 99.6% (95% CI 98.9\u201399.8), while the sensitivity and specificity for trisomy 21 were 50% (95% CI 26.7\u201397.3) and 93.9% (95% CI 92.2\u201395.3), respectively. NIPT had 100% sensitivity and specificity for trisomy 13, 18 and 21, and there were neither false negatives nor false positives. For pregnant women &lt; 35 years, the prevalence of trisomy 13, 18, and 21 per 1,000 births was 0.28 (95% CI 0.12\u20130.67), 0.28 (95% CI 0.12\u20130.67), and 0.89 (95% CI 0.54\u20131.45), respectively. For pregnant women \u226535 years, the prevalence of trisomy 13, 18, and 21 per 1,000 births was 0.26 (95% CI 0.06\u20131.03), 2.59 (95% CI 1.67\u20134.01), and 7.25 (95% CI 5.58\u20139.41), respectively. For all pregnancies, the prevalence of trisomy 13, 18, and 21 per 1,000 births was 0.27 (95% CI 0.13\u20130.57), 0.97 (95% CI 0.66\u20131.44), 2.80 (95% CI 2.22\u20133.52), respectively.<\/jats:p>","DOI":"10.1371\/journal.pone.0284829","type":"journal-article","created":{"date-parts":[[2023,4,20]],"date-time":"2023-04-20T18:38:17Z","timestamp":1682015897000},"page":"e0284829","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":5,"title":["Prenatal screening tests and prevalence of fetal aneuploidies in a tertiary hospital in Thailand"],"prefix":"10.1371","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4660-3961","authenticated-orcid":true,"given":"Preechaya","family":"Wongkrajang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiraphun","family":"Jittikoon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sermsiri","family":"Sangroongruangsri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3668-8754","authenticated-orcid":true,"given":"Pattarawalai","family":"Talungchit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4593-9727","authenticated-orcid":true,"given":"Pornpimol","family":"Ruangvutilert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tachjaree","family":"Panchalee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9457-9823","authenticated-orcid":true,"given":"Usa","family":"Chaikledkaew","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2023,4,20]]},"reference":[{"issue":"5","key":"pone.0284829.ref001","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1177\/2211068214564595","article-title":"An 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