{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T07:28:38Z","timestamp":1777447718838,"version":"3.51.4"},"reference-count":9,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2023,4,21]],"date-time":"2023-04-21T00:00:00Z","timestamp":1682035200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Collaborative research in Japan Organization of Occupational Health and Safety"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>Eight workers involved in packing cross-linked water-soluble acrylic acid polymer, an organic substance, developed pulmonary fibrosis, and the upper lobe was the most affected. The dust concentration in the polymer packing workstation was measured. Chest computed tomography (CT) was obtained for 82 individuals, including the 8 workers mentioned above. Three workers were histopathologically examined. In six of these eight workers, central pulmonary fibrosis and secondary bulla formation caused pneumothorax. Histopathologically, multiple centrilobular fibrotic foci were observed. Chest CT revealed centrilobular nodular opacity and interlobular septal thickening, suggesting early lesions in the workers because the dust concentration was remarkably high. Although the pathogenesis of the disease is unclear, we reported the occurrence of pulmonary fibrosis caused by the exposure to cross-linked water-soluble acrylic acid polymers in humans as it has not been reported earlier.<\/jats:p>","DOI":"10.1371\/journal.pone.0284837","type":"journal-article","created":{"date-parts":[[2023,4,21]],"date-time":"2023-04-21T17:52:59Z","timestamp":1682099579000},"page":"e0284837","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":14,"title":["Respiratory disease in workers handling cross-linked water-soluble acrylic acid polymer"],"prefix":"10.1371","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2718-1713","authenticated-orcid":true,"given":"Takumi","family":"Kishimoto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenzo","family":"Okamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeki","family":"Koda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariko","family":"Ono","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yumi","family":"Umeda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3611-622X","authenticated-orcid":true,"given":"Shotaro","family":"Yamano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoki","family":"Takeda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kammei","family":"Rai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsuya","family":"Kato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasumitsu","family":"Nishimura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoichiro","family":"Kobashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuji","family":"Kawamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2023,4,21]]},"reference":[{"key":"pone.0284837.ref001","first-page":"1","volume-title":"Occupational toxicants: critical data evaluation for MAK values and classification of carcinogens","author":"DFG (Deutsche Forschungsgemeinschaft)","year":"1999"},{"key":"pone.0284837.ref002","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1093\/oxfordjournals.aje.a115710","article-title":"Longitudinal and cross-sectional estimates of pulmonary function decline in never-smoking adults","volume":"132","author":"JH Ware","year":"1990","journal-title":"Am J Epidemiol"},{"key":"pone.0284837.ref003","doi-asserted-by":"crossref","unstructured":"Acrylic acid polymer, neutralized, cross-linked [MAK Value Documentation, 2001]. 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Ministry of Health, Labour, and Welfare. [Cited 13 July 2021]. Available from: https:\/\/www.mhlw.go.jp\/stf\/shingi\/other-roudou_128880_00004.html"},{"key":"pone.0284837.ref009","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.3390\/jcm9041081","article-title":"Sarcoidosis: cause, diagnosis, clinical features, and treatments.","volume":"9","author":"R Jain","year":"2020","journal-title":"J Clin Med"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0284837","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,21]],"date-time":"2023-04-21T17:53:18Z","timestamp":1682099598000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0284837"}},"subtitle":[],"editor":[{"given":"Shama","family":"Ahmad","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2023,4,21]]},"references-count":9,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2023,4,21]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0284837","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,21]]}}}