{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T01:16:38Z","timestamp":1790730998286,"version":"4.1.0"},"reference-count":26,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2023,5,30]],"date-time":"2023-05-30T00:00:00Z","timestamp":1685404800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Globally, neonatal sepsis is the leading cause of neonatal mortality and morbidity, particularly in developing countries. Despite studies that revealed the prevalence of neonatal sepsis in developing countries, the outcome of the diseases, barriers for poor outcomes were inconclusive. The aim of this study was to assess the treatment outcome of neonatal sepsis and its associated factors among neonates admitted to neonatal intensive care unit in public hospitals, Addis Ababa, Ethiopia, 2021.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A cross-sectional study was carried out from February 15 to May 10, 2021 on 308 neonates admitted to neonatal intensive care units of Addis Ababa city public hospitals. Hospitals and study participants were selected by lottery and systematic random sampling techniques, respectively. Data were collected through face-to-face interviews with a structured, pretested questionnaire and by reviewing both the maternal and newborn profile cards. Epi-data version 4.6 was used to enter the collected data, which was then exported to SPSS version 26 for analysis. The 95% CI odds ratio is used to determine the direction and strength of the association between the dependent and independent variables.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among the total study 308 neonates, 75(24.4%) were died. Regarding the poor treatment outcome of neonatal sepsis, neonates whose mothers &lt;37 weeks of gestational age (AOR = 4.87, 95% CI: 1.23\u201319.22), Grunting (AOR 6.94: 1.48\u201332.54), Meconium amniotic stained (AOR = 3.03, 95% CI: 1.02\u20139.01), Duration of rupture of membrane &gt;18hours (AOR = 3.66, 95% CI: (1.20\u201311.15), Hypertensive PIH\/ Eclampsia (AOR = 3.54, 95% CI: 1.24\u201310.09), Meropenum (AOR = 4.16, 95% CI: 1.22\u201314.21) and CRP positive result (AOR = 5.87, 95% CI: 1.53\u201322.56) were significantly associated with poor treatment outcome of neonatal sepsis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusion and recommendation<\/jats:title>\n                    <jats:p>The treatment outcomes of neonates were 75.6% recovered and 24.4% died. In this setting, empirical treatment was the cornerstone for managing neonatal sepsis. Professionals who are working in labor and delivery ward screened for mothers preeclampsia and duration of rupture of membrane &gt;18hrs \/PROM\/ treated with antihypertensive drug and antibiotics for the prevention of neonatal sepsis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0284983","type":"journal-article","created":{"date-parts":[[2023,5,30]],"date-time":"2023-05-30T13:28:25Z","timestamp":1685453305000},"page":"e0284983","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":10,"title":["Treatment outcome of neonatal sepsis and associated factors among neonates admitted to neonatal intensive care unit in public hospitals, Addis Ababa, Ethiopia, 2021. Multi-center cross-sectional study"],"prefix":"10.1371","volume":"18","author":[{"given":"Asalef","family":"Endazanaw","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tefera","family":"Mulugeta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fikertemariam","family":"Abebe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yohannes","family":"Godie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yitayal","family":"Guadie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dires","family":"Birhanu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4751-6023","authenticated-orcid":true,"given":"Esmelealem","family":"Mihretu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2023,5,30]]},"reference":[{"issue":"1","key":"pone.0284983.ref001","article-title":"International pediatric sepsis consensus conference: definitions for sepsis and organ dysfunction in pediatrics","volume":"6","author":"B Goldstein","year":"2017","journal-title":"Pediatric critical caremedicne. journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies"},{"issue":"1","key":"pone.0284983.ref002","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1128\/CMR.00031-13","article-title":"Early-onset of neonatal sepsis","volume":"27","author":"KA Simonsen","year":"2014","journal-title":"Clinical Microbiol Rev"},{"issue":"2","key":"pone.0284983.ref003","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2019\/9369051","article-title":"Risk Factors Associated with Neonatal Sepsis: A Case Study at a Specialist Hospital in Ghana","volume":"3","author":"Peter Adatara","year":"2019","journal-title":"The Scientific World Journal"},{"issue":"3","key":"pone.0284983.ref004","article-title":"Determinants of neonatal sepsis among neonates admitted in a neonatal intensive care unit at jinka general hospital, southern ethiopia","volume":"11","author":"Erkihun Ketema","year":"2019","journal-title":"International Journal of Nursing and Midwifery"},{"key":"pone.0284983.ref005","unstructured":"WHO, World health Statistics. Monitoring health for the SDGs, sustainable development goals. WHO Library Cataloguing-in-Publication Data 2016."},{"issue":"2","key":"pone.0284983.ref006","article-title":"Treatment Outcomes and Associated Factors of Preterm Birth of Neonates Admitted in Intensive Care Unit of Dessie Referral Hospital, North Central Ethiopia","volume":"8","author":"Moges Workneh Ayele","year":"2019","journal-title":"Journal of Nursing and Care"},{"key":"pone.0284983.ref007","unstructured":"Rockville, Maryland, USA. Mini Demographic and Health Survey Ethiopian Public Health Institute. 2019."},{"key":"pone.0284983.ref008","unstructured":"UNICEF. Committing to Child Survival: A Promise Renewed World Health Organ Tech Rep Ser. 2014."},{"key":"pone.0284983.ref009","unstructured":"World Population projections. Ethiopia Demographics Profile. CIA World. 2019."},{"key":"pone.0284983.ref010","unstructured":"Addis Ababa Health Service Information. General Hospital. Addis Ababa health Bureau 2019\/20 (Unpublished)"},{"issue":"4","key":"pone.0284983.ref011","article-title":"Neonatal sepsis in Addis Ababa, Ethiopia: A Review of 151 Bacteremic Neonates","volume":"35","author":"B. Ghiorgis","year":"2014","journal-title":"Ethiop Med journal"},{"issue":"10","key":"pone.0284983.ref012","article-title":"Clinical outcome and risk factors of neonatal sepsis among neonates in Felege Hiwot referral Hospital, Bahir Dar, Amhara Regional State, North West Ethiopia","volume":"265","author":"Tilahun Tewabe","year":"2017","journal-title":"BMC Res Notes"},{"issue":"23","key":"pone.0284983.ref013","article-title":"Background paper neonatal conditions","volume":"6","author":"C Setiawan","year":"2015","journal-title":"Priority Medicines for Europe and the World \"A Public Health Approach to Innovation\""},{"issue":"4,","key":"pone.0284983.ref014","doi-asserted-by":"crossref","first-page":"127","DOI":"10.4102\/sajid.v32i4.37","article-title":"\u201cNeonatal sepsis in a Nigerian tertiary hospital: clinical features, clinical outcome, aetiology and antibiotic susceptibility pattern","volume":"32","author":"A. Arowosegbe","year":"2017","journal-title":"Southern African Journal of Infectious Diseases"},{"issue":"1","key":"pone.0284983.ref015","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1186\/s12887-017-0892-y","article-title":"Bacterial etiologic agents causing neonatal sepsis and associated risk factors in Gondar, Northwest Ethiopia","volume":"17","author":"T MF eyesus","year":"2017","journal-title":"BMC pediatrics"},{"key":"pone.0284983.ref016","article-title":"The global epidemiology of 15 million preterm births","volume":"10","author":"B Hannah","year":"2015","journal-title":"Reproductive Health"},{"key":"pone.0284983.ref017","first-page":"68","article-title":"Survial of preterm infants admitted to Tikur Anbessa Hospital NICU, Addis Ababa","volume":"1","author":"M WB Temesgen","year":"2016","journal-title":"Ethiopian J Pediatrics Child Health"},{"key":"pone.0284983.ref018","first-page":"881","article-title":"Prevalence and perinatal mortality associated with preterm births in a tertiary medical center in south east Nigeria","volume":"6","author":"AL Chukwuemeka","year":"2016","journal-title":"Int J Womens Health"},{"issue":"192","key":"pone.0284983.ref019","article-title":"Neonatal sepsis as a major cause of morbidity in a tericiary center in kathmandu","volume":"52","author":"B Thapa","year":"2016","journal-title":"Nepal Med Assoc"},{"issue":"48","key":"pone.0284983.ref020","article-title":"Risk factors and prognosis for neonatal sepsis in southeastern Mexico: analysis of a four-year historic cohort follow-up","volume":"12","author":"YA Leal","year":"2015","journal-title":"BMC pregnancy and childbirth"},{"issue":"1","key":"pone.0284983.ref021","article-title":"Neonatal sepsis an old problem with new insights USA","volume":"5","author":"BA Shah","year":"2014","journal-title":"Landes Biosci"},{"issue":"21","key":"pone.0284983.ref022","volume":"2","author":"W. Joseph","year":"2021","journal-title":"Nelson textbook of pediatricsInternational, twenty one edition"},{"issue":"1","key":"pone.0284983.ref023","first-page":"120","article-title":"Aetiology risk factors and immediate outcome of bacteriologically confirmed neonatal septicaemia in Mulago Hospital, Uganda","volume":"6","author":"J Mugalu","year":"2016","journal-title":"J Afr Health Sci"},{"issue":"3","key":"pone.0284983.ref024","doi-asserted-by":"crossref","first-page":"415","DOI":"10.32677\/IJCH.2017.v04.i03.033","article-title":"Mortality profile and incidence of deaths due to neonatal sepsis in an urban tertiary care center in South India: a retrospective study","volume":"4","author":"S. Kumar","year":"2017","journal-title":"Indian J Child Health"},{"issue":"6","key":"pone.0284983.ref025","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1038\/sj.jp.7210774","article-title":"The effect of meconium staining of amniotic fluid on the growth of Escherichia coli and group B streptococcus","volume":"22","author":"AI Eidelman","year":"2015","journal-title":"Journal of perinatology official journal of the California Perinatal Association"},{"key":"pone.0284983.ref026","unstructured":"Khair k. Prevalence and outcome in a tertiary neonatal unit in Sudan. 2014."}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0284983","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,30]],"date-time":"2023-05-30T13:28:43Z","timestamp":1685453323000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0284983"}},"subtitle":[],"editor":[{"given":"Sanjoy Kumer","family":"Dey","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2023,5,30]]},"references-count":26,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2023,5,30]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0284983","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,30]]}}}