{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T12:08:54Z","timestamp":1794226134594,"version":"4.8.0"},"reference-count":35,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2023,5,2]],"date-time":"2023-05-02T00:00:00Z","timestamp":1682985600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\"><jats:title>Objective<\/jats:title><jats:p>To compare the rerupture rate after conservative treatment, open repair, and minimally invasive surgery management of acute Achilles tendon ruptures.<\/jats:p><\/jats:sec><jats:sec id=\"sec002\"><jats:title>Design<\/jats:title><jats:p>Systematic review and network meta-analysis.<\/jats:p><\/jats:sec><jats:sec id=\"sec003\"><jats:title>Data sources<\/jats:title><jats:p>We searched Medline, Embase, and the Cochrane Central Register of Controlled Trials from inception to August 2022.<\/jats:p><\/jats:sec><jats:sec id=\"sec004\"><jats:title>Methods<\/jats:title><jats:p>Randomised controlled trials involving different treatments for Achilles tendon rupture were included. The primary outcome was rerupture. Bayesian network meta-analysis with random effects was used to assess pooled relative risks (RRs) and 95% confidence intervals. We evaluated the heterogeneity and publication bias.<\/jats:p><\/jats:sec><jats:sec id=\"sec005\"><jats:title>Results<\/jats:title><jats:p>Thirteen trials with 1465 patients were included. In direct comparison, there was no difference between open repair and minimally invasive surgery for rerupture rate (RR, 0.72, 95% CI 0.10\u20134.4; I<jats:sup>2<\/jats:sup>= 0%; Table 2). Compared to the conservative treatment, the RR was 0.27 (95% CI 0.10\u20130.62, I<jats:sup>2<\/jats:sup>= 0%) for open repair and 0.14 (95% CI 0.01\u20130.88, I<jats:sup>2<\/jats:sup>= 0%) for minimally invasive surgery. The network meta-analysis had obtained the similar results as the direct comparison.<\/jats:p><\/jats:sec><jats:sec id=\"sec006\"><jats:title>Conclusion<\/jats:title><jats:p>Both open repair and minimally invasive surgery were associated with a significant reduction in rerupture rate compared with conservative management, but no difference in rerupture rate was found comparing open repair and minimally invasive surgery.<\/jats:p><\/jats:sec>","DOI":"10.1371\/journal.pone.0285046","type":"journal-article","created":{"date-parts":[[2023,5,2]],"date-time":"2023-05-02T17:30:43Z","timestamp":1683048643000},"page":"e0285046","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":20,"title":["Rerupture outcome of conservative versus open repair versus minimally invasive repair of acute Achilles tendon ruptures: A systematic review and meta-analysis"],"prefix":"10.1371","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5827-8847","authenticated-orcid":true,"given":"Haidong","family":"Deng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jialing","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixin","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiangui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangchun","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuning","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weelic","family":"Chong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Hai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4571-7171","authenticated-orcid":true,"given":"Yu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2023,5,2]]},"reference":[{"issue":"1","key":"pone.0285046.ref001","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1007\/s12178-017-9386-7","article-title":"Achilles 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