{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:16:38Z","timestamp":1787836598273,"version":"build-2784847793"},"reference-count":24,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2023,5,5]],"date-time":"2023-05-05T00:00:00Z","timestamp":1683244800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"crossref","award":["2021R1A2C3004532"],"award-info":[{"award-number":["2021R1A2C3004532"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Purpose<\/jats:title>\n<jats:p>To investigate the causes of bullous keratopathy (BK) in the Korean population and analyze the results of penetrating keratoplasty (PK) in BK eyes associated with the top two causes: pseudophakic bullous keratopathy (PBK) and glaucoma surgery-associated BK (GBK).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>Medical records were reviewed of patients diagnosed with BK at a tertiary referral center between 2010 and 2020. The predisposing conditions, clinical characteristics and therapeutic outcomes after PK were analyzed and compared.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>Of total 340 BK eyes, 70% (238 eyes) were associated with ocular surgery; most commonly, cataract surgery (48%, 162 eyes) and glaucoma surgery\/laser (21%, 70 eyes). The BK onset was faster following glaucoma surgery\/laser (91.7 \u00b1 94.4 months) than following cataract surgery (160.7 \u00b1 138.0 months, <jats:italic>p<\/jats:italic> &lt; 0.001). The median survival time of allografts was shorter in GBK than in PBK (24.0 vs 51.0 months, <jats:italic>p<\/jats:italic> = 0.020). Best-corrected logMAR visual acuities were lower in GBK than in PBK after PK (1.4 \u00b1 0.7 vs 0.9 \u00b1 0.6, <jats:italic>p<\/jats:italic> = 0.017 at one year; 1.8 \u00b1 0.7 vs 1.1 \u00b1 0.8, <jats:italic>p<\/jats:italic> = 0.043 at three years).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusions<\/jats:title>\n<jats:p>Intraocular surgery is the major predisposing condition of BK in Korea. GBK developed earlier and its therapeutic outcome was poorer, compared to PBK.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0285419","type":"journal-article","created":{"date-parts":[[2023,5,5]],"date-time":"2023-05-05T17:36:33Z","timestamp":1683308193000},"page":"e0285419","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":9,"title":["Etiology and outcome of penetrating keratoplasty in bullous keratopathy post-cataract surgery vs post-glaucoma surgery"],"prefix":"10.1371","volume":"18","author":[{"given":"Young-ho","family":"Jung","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyuk Jin","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mee Kum","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7899-5314","authenticated-orcid":true,"given":"Joo Youn","family":"Oh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2023,5,5]]},"reference":[{"key":"pone.0285419.ref001","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/s10792-007-9177-z","article-title":"Trends in penetrating keratoplasty in the United States 1980\u20132005.","volume":"28","author":"FR Ghosheh","year":"2008","journal-title":"Int Ophthalmol"},{"key":"pone.0285419.ref002","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1097\/TP.0000000000001281","article-title":"Changing Indications in Penetrating Keratoplasty: A Systematic Review of 34 Years of Global Reporting","volume":"101","author":"M Matthaei","year":"2017","journal-title":"Transplantation"},{"key":"pone.0285419.ref003","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1007\/s11845-020-02340-1","article-title":"Changing trends in corneal transplantation: a national review of current practices in the Republic of Ireland","volume":"190","author":"KC Iselin","year":"2021","journal-title":"Ir J Med Sci"},{"key":"pone.0285419.ref004","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1001\/jamaophthalmol.2015.4776","article-title":"Global Survey of Corneal Transplantation and Eye Banking.","volume":"134","author":"P Gain","year":"2016","journal-title":"JAMA Ophthalmology"},{"key":"pone.0285419.ref005","doi-asserted-by":"crossref","first-page":"100904","DOI":"10.1016\/j.preteyeres.2020.100904","article-title":"Corneal endothelial dysfunction: Evolving understanding and treatment options.","volume":"82","author":"MO Price","year":"2021","journal-title":"Prog Retin Eye Res."},{"key":"pone.0285419.ref006","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1097\/ICO.0b013e31802c9e19","article-title":"Japan Bullous Keratopathy Study Group. National survey on bullous keratopathy in Japan","volume":"26","author":"J Shimazaki","year":"2007","journal-title":"Cornea"},{"key":"pone.0285419.ref007","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.ajo.2012.09.020","article-title":"Five-year follow-up results of photodynamic therapy for polypoidal choroidal vasculopathy","volume":"155","author":"HM Kang","year":"2013","journal-title":"Am J Ophthalmol"},{"key":"pone.0285419.ref008","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.1016\/j.ophtha.2007.06.047","article-title":"Visual acuity as an outcome measure in clinical trials of retinal diseases","volume":"114","author":"RW Beck","year":"2007","journal-title":"Ophthalmology"},{"key":"pone.0285419.ref009","first-page":"34","article-title":"Applanation tonometry and central corneal thickness.","volume":"86","author":"N Ehlers","year":"2008","journal-title":"Acta Ophthalmol"},{"key":"pone.0285419.ref010","first-page":"149","article-title":"General relationship between corneal thickness and applanation tonometry readings: implications for glaucoma screening.","volume":"12","author":"MJ Doughty","year":"1992","journal-title":"Ophthalmic Physiol Opt"},{"key":"pone.0285419.ref011","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1007\/s00417-010-1606-4","article-title":"Analysis of causes of bullous keratopathy in East China: a 10-year retrospective study","volume":"250","author":"X Wang","year":"2012","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"pone.0285419.ref012","doi-asserted-by":"crossref","first-page":"90","DOI":"10.22336\/rjo.2017.17","article-title":"Pseudophakic bullous keratopathy.","volume":"61","author":"S Pricopie","year":"2017","journal-title":"Rom J Ophthalmol"},{"key":"pone.0285419.ref013","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1076\/soph.17.3.110.14783","article-title":"Corneal edema after cataract surgery: incidence and etiology","volume":"17","author":"DH Yi","year":"2002","journal-title":"Semin Ophthalmol"},{"key":"pone.0285419.ref014","doi-asserted-by":"crossref","first-page":"581","DOI":"10.2147\/CLEP.S310542","article-title":"Trends in Surgical Glaucoma Treatment in Germany Between 2006 and 2018.","volume":"13","author":"J Luebke","year":"2021","journal-title":"Clin Epidemiol."},{"key":"pone.0285419.ref015","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s12886-019-1027-z","article-title":"Long-term results of glaucoma drainage device surgery","volume":"19","author":"K Purtskhvanidze","year":"2019","journal-title":"BMC Ophthalmol"},{"key":"pone.0285419.ref016","doi-asserted-by":"crossref","first-page":"e0024","DOI":"10.5041\/RMMJ.10345","article-title":"Evolution of Glaucoma Surgery in the Last 25 Years.","volume":"9","author":"L Bar-David","year":"2018","journal-title":"Rambam Maimonides Med J."},{"key":"pone.0285419.ref017","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1016\/j.ophtha.2008.12.050","article-title":"Recipient risk factors for graft failure in the cornea donor study","volume":"116","author":"A Sugar","year":"2009","journal-title":"Ophthalmology"},{"key":"pone.0285419.ref018","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1016\/S0161-6420(94)31138-9","article-title":"Risk factors for corneal graft failure and rejection in the collaborative corneal transplantation studies. 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