{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T17:23:55Z","timestamp":1790011435701,"version":"4.0.1"},"reference-count":22,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2023,5,8]],"date-time":"2023-05-08T00:00:00Z","timestamp":1683504000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Mojeaga International Ventures Ltd, Nigeria"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"\n Background<\/jats:title>\n \n To our knowledge, there is no prior randomized trial on the efficacy of Mojeaga remedy (a special blend of\n Alchornea cordifolia<\/jats:italic>\n ,\n Pennisetum glaucum<\/jats:italic>\n and\n Sorghum bicolor extracts<\/jats:italic>\n ) when co-administered with standard-of-care for correction of anemia in obstetrics practice. This study determined the efficacy, safety and tolerability of Mojeaga as adjunct to conventional oral iron therapy for correction of anemia in obstetric population.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n A pilot open-label randomized clinical trial. Participants with confirmed diagnosis of anemia in three tertiary hospitals in Nigeria were studied. Eligible participants were randomized 1:1 to either Mojeaga syrups 50 mls (200mg\/50mls) administered three times daily in conjunction with conventional iron therapy (Mojeaga group) for 2 weeks or conventional iron therapy alone without Mojeaga (standard-of-care group) for 2 weeks. Repeat hematocrit level were done 2 weeks post-initial therapy. Primary outcome measures were changes in hematocrit level and median hematocrit level at two weeks post therapy. Maternal adverse events and neonatal outcomes (birth anomalies, low birthweight, preterm rupture of membranes and preterm labor) were considered the safety outcome measures. Analysis was by intention-to-treat.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Ninety five participants were enrolled and randomly assigned to the Mojeaga group (n = 48) or standard-of-care group (n = 47). The baseline socio-demographic and clinical characteristics of the study participants were similar. At two weeks follow-up the median rise in hematocrit values from baseline (10.00\u00b17.00% vs 6.00\u00b14.00%;p<0.001) and median hematocrit values (31.00\u00b12.00% vs 27.00\u00b13.00%;p<0.001) were significantly higher in the Mojeaga group. There were no treatment-related serious adverse events, congenital anomalies or deaths in the Mojeaga group and incidence of other neonatal outcomes were similar (p>0.05).<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Mojeaga represents a new adjuvants for standard-of-care option for patients with anemia. Mojeaga remedy is safe for treating anemia during pregnancy and puerperium without increasing the incidence of congenital anomalies, or adverse neonatal outcomes.<\/jats:p>\n <\/jats:sec>\n \n Clinical trial registration<\/jats:title>\n \n \n www.pactr.samrc.ac.za<\/jats:bold>\n <\/jats:ext-link>\n :\n PACTR201901852059636<\/jats:ext-link>\n (\n https:\/\/pactr.samrc.ac.za\/TrialDisplay.aspx?TrialID=5822<\/jats:ext-link>\n ).\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1371\/journal.pone.0285474","type":"journal-article","created":{"date-parts":[[2023,5,8]],"date-time":"2023-05-08T14:32:49Z","timestamp":1683556369000},"page":"e0285474","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":3,"title":["Efficacy and safety of Mojeaga remedy in combination with conventional oral iron therapy for correcting anemia in obstetric population: A phase II randomized pilot clinical trial"],"prefix":"10.1371","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0390-2152","authenticated-orcid":true,"given":"George Uchenna","family":"Eleje","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ifeanyichukwu Uzoma","family":"Ezebialu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph Tochukwu","family":"Enebe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nnanyelugo Chima","family":"Ezeora","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3342-434X","authenticated-orcid":true,"given":"Emmanuel Onyebuchi","family":"Ugwu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iffiyeosuo Dennis","family":"Ake","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekeuda Uchenna","family":"Nwankwo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Perpetua Kelechi","family":"Enyinna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5772-661X","authenticated-orcid":true,"given":"Chukwuemeka Chukwubuikem","family":"Okoro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chika Prince","family":"Asuoha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte Blanche","family":"Oguejiofor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ejeatuluchukwu","family":"Obi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4458-8216","authenticated-orcid":true,"given":"Chigozie Geoffrey","family":"Okafor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela Ogechukwu","family":"Ugwu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lydia Ijeoma","family":"Eleje","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Divinefavour Echezona","family":"Malachy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chukwunonso Emmanuel","family":"Ubammadu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emeka Philip","family":"Igbodike","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chidebe Christian","family":"Anikwe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ifeoma Clara","family":"Ajuba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chinyelu Uchenna","family":"Ufoaroh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard Obinwanne","family":"Egeonu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lazarus Ugochukwu","family":"Okafor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chukwunonso Isaiah","family":"Enechukwu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sussan Ifeyinwa","family":"Nweje","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Onyedika Promise","family":"Anaedu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Odigonma Zinobia","family":"Ikpeze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boniface Chukwuneme","family":"Okpala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekene Agatha","family":"Emeka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1676-5721","authenticated-orcid":true,"given":"Chijioke Stanley","family":"Nzeukwu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ifeanyi Chibueze","family":"Aniedu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel Chidi","family":"Chukwuka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arinze Anthony","family":"Onwuegbuna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1465-7033","authenticated-orcid":true,"given":"David Chibuike","family":"Ikwuka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chisom God\u2019swill","family":"Chigbo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiemezie Mac-Kingsley","family":"Agbanu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chidinma Ifechi","family":"Onwuka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malarchy Ekwunife","family":"Nwankwo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry Chinedu","family":"Nneji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8684-8069","authenticated-orcid":true,"given":"Kosisochukwu Amarachukwu","family":"Onyeukwu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boniface Uwaezuoke","family":"Odugu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvester Onuegbunam","family":"Nweze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ifeanyi Johnson","family":"Onyekpa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6346-2905","authenticated-orcid":true,"given":"Kenneth Chukwudi","family":"Eze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shirley Nneka","family":"Chukwurah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph Odirichukwu","family":"Ugboaja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph Ifeanyichukwu","family":"Ikechebelu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2023,5,8]]},"reference":[{"issue":"11","key":"pone.0285474.ref001","doi-asserted-by":"crossref","first-page":"2156S","DOI":"10.3945\/jn.117.252429","article-title":"The Lives Saved Tool (LiST) as a Model for Prevention of Anemia in Women of Reproductive Age","volume":"147","author":"R Heidkamp","year":"2017","journal-title":"J Nutr"},{"key":"pone.0285474.ref002","doi-asserted-by":"crossref","first-page":"2475","DOI":"10.2147\/DDDT.S55499","article-title":"Optimizing iron delivery in the management of anemia: patient considerations and the role of ferric carboxymaltose","volume":"8","author":"JE Toblli","year":"2014","journal-title":"Drug Des Devel Ther"},{"key":"pone.0285474.ref003","doi-asserted-by":"crossref","first-page":"48","DOI":"10.12688\/gatesopenres.12866.2","article-title":"A novel nano-iron supplement to safely combat iron deficiency and anaemia in young children: The IHAT-GUT double-blind, randomised, placebo-controlled trial protocol","volume":"2","author":"DIA Pereira","year":"2018","journal-title":"Gates Open Res"},{"issue":"1","key":"pone.0285474.ref004","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1186\/s12884-018-1817-y","article-title":"Efficacy and safety of ferric carboxymaltose versus ferrous sulfate for iron deficiency anemiaduring pregnancy: subgroup analysis of Korean women","volume":"18","author":"JY Shim","year":"2018","journal-title":"BMC Pregnancy Childbirth"},{"issue":"4","key":"pone.0285474.ref005","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1515\/jpm-2016-0050","article-title":"Ferric carboxymaltose vs. oral iron in the treatment of pregnant women with iron deficiency anemia: an international, open-label, randomized controlled trial (FER-ASAP)","volume":"45","author":"FER-ASAP investigators","year":"2017","journal-title":"J Perinat Med"},{"issue":"4","key":"pone.0285474.ref006","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1053\/j.seminhematol.2018.04.006","article-title":"A Prospective Randomised Controlled Trial of a Single Intravenous Infusion of Ferric Carboxymaltose vs Single Intravenous Iron Polymaltose or Daily Oral Ferrous Sulphate in the Treatment of Iron Deficiency Anaemia in Pregnancy","volume":"55","author":"AA Khalafallah","year":"2018","journal-title":"Semin Hematol"},{"key":"pone.0285474.ref007","doi-asserted-by":"crossref","first-page":"608","DOI":"10.4103\/1119-3077.141427","article-title":"Determinants of compliance to iron supplementation among pregnant women in Enugu, Southeastern Nigeria","volume":"17","author":"EO Ugwu","year":"2014","journal-title":"Niger J Clin Pract"},{"issue":"8","key":"pone.0285474.ref008","doi-asserted-by":"crossref","first-page":"367","DOI":"10.5694\/mja2.50308","article-title":"Intravenous or oral iron for treating iron deficiency anaemia during pregnancy: systematic review and meta-analysis","volume":"211","author":"A Qassim","year":"2019","journal-title":"Med J Aust"},{"issue":"1","key":"pone.0285474.ref009","first-page":"01","article-title":"Successful management of severe anemia without blood transfusion in pregnancy and puerperium using Mojeaga\u00ae as adjunct therapy: A report of two cases","volume":"1","author":"GU Eleje","year":"2018","journal-title":"Hong Kong J Obst Gynae"},{"key":"pone.0285474.ref010","unstructured":"Peter. 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Assessed on 23rd December, 2018."},{"issue":"6","key":"pone.0285474.ref012","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1111\/bjh.16221","article-title":"UK guidelines on the management of iron deficiency in pregnancy","volume":"188","author":"S Pavord","year":"2020","journal-title":"Br J Haematol"},{"issue":"5","key":"pone.0285474.ref013","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1111\/j.1365-2141.2011.09012.x","article-title":"UK guidelines on the management of iron deficiency in pregnancy","volume":"156","author":"S Pavord","year":"2012","journal-title":"Br J Haematol"},{"issue":"6","key":"pone.0285474.ref014","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1111\/bjh.16220","article-title":"Guidelines for iron deficiency in pregnancy: hope abounds: Commentary to accompany: UK guidelines on the management of iron deficiency in pregnancy","volume":"188","author":"M Auerbach","year":"2020","journal-title":"Br J Haematol"},{"issue":"6","key":"pone.0285474.ref015","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajog.2021.06.069","article-title":"Addition of oral iron bisglycinate to intravenous iron sucrose for the treatment of postpartum anemia-randomized controlled trial","volume":"225","author":"E Yefet","year":"2021","journal-title":"Am J Obstet Gynecol"},{"issue":"2","key":"pone.0285474.ref016","doi-asserted-by":"crossref","first-page":"447","DOI":"10.3390\/nu12020447","article-title":"Iron Deficiency and Iron Deficiency Anemia: Implications and Impact in Pregnancy, Fetal Development, and Early Childhood Parameters","volume":"12","author":"RT Means","year":"2020","journal-title":"Nutrients"},{"key":"pone.0285474.ref017","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s43088-022-00207-1","article-title":"Phytochemical screening, antioxidant study and hematinic property of Mojeaga herbal remedy using animal model","volume":"11","author":"M Idu","year":"2022","journal-title":"Beni-Suef Univ J Basic Appl Sci"},{"issue":"2","key":"pone.0285474.ref018","first-page":"13","article-title":"Toxicological evaluation of Mojeaga herbal remedy on experimental animals","volume":"4","author":"M Idu","year":"2020","journal-title":"J Basic Pharmacol Toxicol"},{"issue":"3","key":"pone.0285474.ref019","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1590\/2176-9451.20.3.013-015.ebo","article-title":"CONSORT: when and how to use it","volume":"20","author":"SG Falci","year":"2015","journal-title":"Dental Press J Orthod"},{"issue":"7\u20138","key":"pone.0285474.ref020","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/j.gyobfe.2004.05.014","article-title":"An\u00e9mies s\u00e9v\u00e8res du post-partum imm\u00e9diat. Pratique clinique et int\u00e9r\u00eat du fer par voie intraveineuse [Acute postpartum anaemia. Clinical practice and interest of intravenous iron]","volume":"32","author":"DE Broche","year":"2004","journal-title":"Gynecol Obstet Fertil"},{"key":"pone.0285474.ref021","doi-asserted-by":"crossref","first-page":"d6068","DOI":"10.1136\/bmj.d6068","article-title":"Phases of clinical trials","volume":"343","author":"P. Sedgwick","year":"2011","journal-title":"BMJ"},{"key":"pone.0285474.ref022","doi-asserted-by":"crossref","first-page":"g3434","DOI":"10.1136\/bmj.g3434","article-title":"What is an open label trial?","volume":"348","author":"P. Sedgwick","year":"2014","journal-title":"BMJ"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0285474","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,8]],"date-time":"2023-05-08T14:33:19Z","timestamp":1683556399000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0285474"}},"subtitle":[],"editor":[{"given":"Ahmed Mohamed","family":"Maged","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2023,5,8]]},"references-count":22,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2023,5,8]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0285474","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2022.09.21.22280196","asserted-by":"object"}]},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,8]]}}}