{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:35:55Z","timestamp":1789518955862,"version":"build-2803163510"},"reference-count":38,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T00:00:00Z","timestamp":1692230400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>Schistosomiasis is a parasitic infection that causes significant public health problems in tropical countries. <jats:italic>Schistosoma haematobium<\/jats:italic> species are blamable for causing urinary schistosomiasis. The infected person, specifically children, may be carrying the disease. This systematic review aimed to identify the current knowledge of urinary Schistosmiasis in children or USC on its epidemiology, risk factors, and challenges to spread the understanding of controlling the disease and reducing the complications.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Method<\/jats:title>\n<jats:p>In November 2021, a systematic computer-aided literature review was conducted using PubMed, SCOPUS and Web of Science, following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) criteria. The results were updated in February 2022. We only used papers that have at least the abstract available in English. Relevant articles were screened, duplicates were deleted, eligibility criteria were applied, and studies that met the criteria were reviewed. The keywords Human Schistosoma infections, prevalence, risk factors and challenges were included. The protocol for the review was registered with PROSPERO (registration number CRD42022311609). Pooled prevalence rates were calculated using the programme R version 4.2.1. Heterogeneity was assessed using the I2 statistic and p-value. A narrative approach was used to describe risk factors and challenges. Studies were selected and finalised based on the review question to prioritise. The quality of the included studies was assessed using the Mixed-Method Appraisal Tool (MMAT).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>A total of 248 publications met the requirements for inclusion. Fifteen articles were included in this review, with the result showing high heterogeneity. The pooled prevalence of urinary schistosomiasis in children is 4% (95% confidence interval (CI)). Age, poor socioeconomic status, education, exposure to river water, and poor sanitation are the risk factors identified in this review. Challenges are faced due to limitations of clean water, lack of water resources, and poor hygiene.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>Modifiable risk factors such as poor knowledge and practices must be addressed immediately. Healthcare providers and schools could accomplish engaging in practical promotional activities. Communicating the intended messages to raise community awareness of urinary schistosomiasis is critical.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0285533","type":"journal-article","created":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T17:46:10Z","timestamp":1692294370000},"page":"e0285533","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":8,"title":["Systematic review with meta-analysis: Prevalence, risk factors, and challenges for urinary schistosomiasis in children (USC)"],"prefix":"10.1371","volume":"18","author":[{"given":"Noor Azreen","family":"Masdor","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thinakaran","family":"Kandayah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norizzati","family":"Amsah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahayu","family":"Othman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4658-6532","authenticated-orcid":true,"given":"Mohd Rohaizat","family":"Hassan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9090-2563","authenticated-orcid":true,"given":"Syed Sharizman Syed Abdul","family":"Rahim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Saffree","family":"Jeffree","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khamisah","family":"Awang Lukman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1524-541X","authenticated-orcid":true,"given":"Aizuddin","family":"Hidrus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2023,8,17]]},"reference":[{"issue":"26","key":"pone.0285533.ref001","doi-asserted-by":"crossref","first-page":"2519","DOI":"10.1056\/NEJMoa1812165","article-title":"Schistosomiasis\u2014Assessing Progress toward the 2020 and 2025 Global Goals.","volume":"381","author":"AK Deol","year":"2019","journal-title":"N Engl J Med [Internet]."},{"key":"pone.0285533.ref002","author":"World Health Organization","year":"2021","journal-title":"Schistosomiasis and soil-transmitted helminthiases: progress report, 2020 [Internet]."},{"key":"pone.0285533.ref003","article-title":"Schistosomiasis\u2014Infectious Diseases\u2014MSD Manual Professional Edition [Internet].","author":"M Chelsea","year":"2021","journal-title":"Merck Sharp & Dohme Corp"},{"key":"pone.0285533.ref004","article-title":"Schistosomiasis [Internet].","author":"CDC","year":"2019","journal-title":"Division of Parasitic Diseases and Malaria CDC"},{"key":"pone.0285533.ref005","volume-title":"Schistosomiasis [Internet].","author":"WHO","year":"2021"},{"issue":"1","key":"pone.0285533.ref006","first-page":"1","article-title":"Urogenital schistosomiasis and risk factors of infection in mothers and preschool children in an endemic district in Zimbabwe.","volume":"12","author":"MJ Mutsaka-Makuvaza","year":"2019","journal-title":"Parasites and Vectors [Internet]."},{"issue":"1","key":"pone.0285533.ref007","first-page":"1","article-title":"Role of a schistosoma haematobium specific microRNA as a predictive and prognostic tool for bilharzial bladder cancer in Egypt","volume":"10","author":"DA Gaber","year":"2020","journal-title":"Sci Reports 2020 101 [Internet]."},{"issue":"1","key":"pone.0285533.ref008","first-page":"1","article-title":"Prevalence and risk factors of schistosomiasis and soil-transmitted helminthiases among preschool aged children (1\u20135 years) in rural KwaZulu-Natal, South Africa: A cross-sectional study.","volume":"8","author":"H Sacolo-Gwebu","year":"2019","journal-title":"Infect Dis Poverty [Internet]."},{"issue":"1","key":"pone.0285533.ref009","article-title":"Asian Schistosomiasis: Current Status and Prospects for Control Leading to Elimination","volume":"4","author":"CA Gordon","year":"2019","journal-title":"Trop Med Infect Dis [Internet]."},{"issue":"2","key":"pone.0285533.ref010","article-title":"Paediatric schistosomiasis: What we know and what we need to know.","volume":"12","author":"DNM Osakunor","year":"2018","journal-title":"PLoS Negl Trop Dis [Internet]."},{"key":"pone.0285533.ref011","doi-asserted-by":"crossref","first-page":"e00208","DOI":"10.1016\/j.parepi.2021.e00208","article-title":"Adherence to diagnosis followed by selective treatment of schistosomiasis mansoni and related knowledge among schoolchildren in an endemic area of Minas Gerais, Brazil, prior to and after the implementation of educational actions.","volume":"13","author":"TC Favre","year":"2021","journal-title":"Parasite Epidemiol Control."},{"issue":"1","key":"pone.0285533.ref012","doi-asserted-by":"crossref","first-page":"10","DOI":"10.4314\/mmj.v28i1.3","article-title":"Urinary schistosomiasis among preschool children in Malengachanzi, Nkhotakota District, Malawi: Prevalence and risk factors.","volume":"28","author":"VB Moyo","year":"2016","journal-title":"Malawi Med J."},{"issue":"9","key":"pone.0285533.ref013","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pntd.0005872","article-title":"Spatial distribution and risk factors of Schistosoma haematobium and hookworm infections among schoolchildren in Kwale, Kenya.","volume":"11","author":"EA Chadeka","year":"2017","journal-title":"PLoS Negl Trop Dis"},{"issue":"1","key":"pone.0285533.ref014","first-page":"1","article-title":"Schistosomiasis vaccine development: Update on human clinical trials","volume":"27","author":"AJ Molehin","year":"2020","journal-title":"J Biomed Sci [Internet]."},{"issue":"3","key":"pone.0285533.ref015","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1097\/XEB.0000000000000054","article-title":"Methodological guidance for systematic reviews of observational epidemiological studies reporting prevalence and cumulative incidence data.","volume":"13","author":"Z Munn","year":"2015","journal-title":"Int J Evid Based Healthc [Internet]."},{"issue":"2","key":"pone.0285533.ref016","first-page":"284","article-title":"Epidemiology of urinary schistosomiasis among school children in the alsaial Alsagair village, River nile state, Sudan.","volume":"12","author":"Y Sulieman","year":"2017","journal-title":"Iran J Parasitol"},{"issue":"6","key":"pone.0285533.ref017","first-page":"1395","article-title":"of Kidney Diseases and Transplantation Renal Data from Asia\u2013Africa Urinary Schistosomiasis in Boko Haram-related Internally Displaced Nigerian Children.","volume":"29","author":"SM Yauba","year":"2018"},{"key":"pone.0285533.ref018","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.ijid.2018.04.002","article-title":"Infection status and risk factors associated with urinary schistosomiasis among school-going children in the Ndumo area of uMkhanyakude District in KwaZulu-Natal, South Africa two years post-treatment","volume":"71","author":"M Kabuyaya","year":"2018","journal-title":"Int J Infect Dis [Internet]."},{"issue":"1","key":"pone.0285533.ref019","first-page":"1","article-title":"Confounding influences of malnutrition and Plasmodium falciparum and Schistosoma haematobium infections on haematological parameters in school children in Muyuka, Cameroon.","volume":"21","author":"IUN Sumbele","year":"2021","journal-title":"BMC Infect Dis"},{"issue":"1","key":"pone.0285533.ref020","first-page":"1","article-title":"Prevalence of schistosomiasis and associated risk factors among school children in Um-Asher Area, Khartoum, Sudan.","volume":"11","author":"K Hajissa","year":"2018","journal-title":"BMC Res Notes [Internet]."},{"issue":"5","key":"pone.0285533.ref021","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pntd.0009380","article-title":"Prevalence and risk factors of schistosomiasis among primary school children in four selected regions of the gambia.","volume":"15","author":"E Joof","year":"2021","journal-title":"PLoS Negl Trop Dis"},{"key":"pone.0285533.ref022","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/6913918","article-title":"Urogenital Schistosomiasis among Schoolchildren and the Associated Risk Factors in Selected Rural Communities of Kwara State, Nigeria.","volume":"2018","author":"BO Abdulkareem","year":"2018","journal-title":"J Trop Med"},{"issue":"1","key":"pone.0285533.ref023","first-page":"1","article-title":"Prevalence and seasonal transmission of Schistosoma haematobium infection among school-aged children in Kaedi town, southern Mauritania.","volume":"10","author":"NGC Gbal\u00e9gba","year":"2017","journal-title":"Parasites and Vectors"},{"key":"pone.0285533.ref024","author":"EK Angora","year":"2019","journal-title":"Prevalence and Risk Factors for Schistosomiasis among Schoolchildren in two Settings of C \u00f4 te d \u2018 Ivoire"},{"issue":"3\u20134","key":"pone.0285533.ref025","first-page":"2","article-title":"Co-infection with Schistosoma haematobium and soil-transmitted helminths in rural South Africa","volume":"113","author":"M Molvik","year":"2017","journal-title":"S Afr J Sci"},{"issue":"5","key":"pone.0285533.ref026","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1179\/136485910X12743554760469","article-title":"Factors associated with urinary schistosomiasis in two peri-urban communities in south-western Nigeria","volume":"104","author":"US Ugbomoiko","year":"2010","journal-title":"Ann Trop Med Parasitol"},{"issue":"1","key":"pone.0285533.ref027","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s40249-017-0257-7","article-title":"Assessing the prevalence of urogenital schistosomaisis and transmission risk factors amongst school-aged children around Map\u00e9 dam ecological suburbs in Malantouen district, Cameroon.","volume":"6","author":"AP Mewabo","year":"2017","journal-title":"Infect Dis Poverty"},{"issue":"1","key":"pone.0285533.ref028","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/S1995-7645(13)60188-1","article-title":"Prevalence, intensity of infection and risk factors of urinary schistosomiasis in pre-school and school aged children in Guma Local Government Area, Nigeria.","volume":"7","author":"EU Amuta","year":"2014","journal-title":"Asian Pac J Trop Med"},{"issue":"1","key":"pone.0285533.ref029","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13071-015-0822-5","article-title":"Prevalence of urinary schistosomiasis and associated risk factors among Abobo Primary School children in Gambella Regional State, southwestern Ethiopia: A cross sectional study.","volume":"8","author":"S Geleta","year":"2015","journal-title":"Parasites and Vectors."},{"issue":"1","key":"pone.0285533.ref030","doi-asserted-by":"crossref","DOI":"10.1186\/1756-3305-7-5","article-title":"Prevalence and intensity of urinary schistosomiasis among school children in the district of Niakhar, region of Fatick, Senegal.","volume":"7","author":"B Senghor","year":"2014","journal-title":"Parasites and Vectors."},{"issue":"1","key":"pone.0285533.ref031","first-page":"1","article-title":"Malaria, helminths and malnutrition: A cross-sectional survey of school children in the South-Tongu district of Ghana.","volume":"9","author":"PF Ayeh-Kumi","year":"2016","journal-title":"BMC Res Notes"},{"issue":"November","key":"pone.0285533.ref032","first-page":"1","article-title":"Schistosomiasis and climate change","volume":"371","author":"GA De Leo","year":"2020","journal-title":"BMJ"},{"key":"pone.0285533.ref033","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/9831265","article-title":"Urinary schistosomiasis among children in Murbai and Surbai communities of Ardo-Kola Local Government Area, Taraba State, Nigeria.","volume":"2016","author":"RS Houmsou","year":"2016","journal-title":"J Trop Med"},{"issue":"6","key":"pone.0285533.ref034","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.4103\/1319-2442.248286","article-title":"Renal Data from Asia-Africa Urinary Schistosomiasis in Boko Haram-related Internally Displaced Nigerian Children.","volume":"29","author":"S Mohammed Yauba","year":"2018","journal-title":"Saudi J Kidney Dis Transpl [Internet]."},{"issue":"2","key":"pone.0285533.ref035","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.parepi.2018.02.003","article-title":"Epidemiology of intestinal parasite infections in three departments of south-central C\u00f4te d\u2019Ivoire before the implementation of a cluster-randomised trial.","volume":"3","author":"G Coulibaly","year":"2018","journal-title":"Parasite Epidemiol Control"},{"issue":"2","key":"pone.0285533.ref036","first-page":"67","article-title":"Schistosomiasis risk factors based on the infection status among school-going children in the Ndumo area, uMkhanyakude district, South Africa","volume":"32","author":"M Kabuyaya","year":"2017","journal-title":"South African J Infect Dis [Internet]."},{"key":"pone.0285533.ref037","first-page":"1","article-title":"Knowledge, attitudes and practices pertaining to urogenital schistosomiasis in Lambar\u00e9n\u00e9 and surrounding areas, Gabon.","author":"J Claude","year":"2021","journal-title":"Parasit Vectors."},{"key":"pone.0285533.ref038","doi-asserted-by":"crossref","first-page":"141881","DOI":"10.1016\/j.scitotenv.2020.141881","article-title":"Science of the Total Environment Faeces\u2013Urine separation via settling and displacement: Prototype tests for a novel non-sewered sanitation system","volume":"753","author":"J Hennigs","year":"2021","journal-title":"Sci Total Environ"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0285533","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T17:46:44Z","timestamp":1692294404000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0285533"}},"subtitle":[],"editor":[{"given":"Clement Ameh","family":"Yaro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2023,8,17]]},"references-count":38,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2023,8,17]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0285533","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,17]]}}}