{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T13:04:52Z","timestamp":1783947892800,"version":"3.55.0"},"reference-count":24,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2023,5,16]],"date-time":"2023-05-16T00:00:00Z","timestamp":1684195200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>Esophageal atresia (EA) with or without tracheoesophageal fistula (TEF) is the most common congenital anomaly of the esophagus. This anomaly continues to cause considerable morbidity and mortality in Sub-Saharan Africa, presenting various concerns about how to treat esophageal atresia. Esophageal atresia-related neonatal mortality can be reduced by evaluating the surgical outcome and identifying associated factors.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Objective<\/jats:title>\n<jats:p>This study aimed to assess the surgical outcome and identify predictors of neonates with esophageal atresia admitted at Tikur Anbesa specialized hospital.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Methods<\/jats:title>\n<jats:p>Retrospective crossectional study design was employed on 212 neonates with esophageal atresia who were undergone surgical intervention in Tikur Anbesa specialized hospital. Data were entered into epi data 4.6 and exported to Stata version 16 software for further analysis. A logistic regression model with Adjusted odds ratio (AOR), confidence interval (CI) and p-value &lt;0.05 were used to identify predictors of poor surgical outcome of neonates with esophageal atresia.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Result<\/jats:title>\n<jats:p>In this study, 25% of newborns who underwent surgical intervention at TikurAbnbesa specialized hospital had successful surgical outcomes, compared to 75% of neonates with esophageal atresia who had poor surgical outcomes. Significant predictors of the poor surgical outcome of neonates with esophageal atresia were severe thrombocytopenia (AOR = 2.81(1.07\u20137.34)), timing of surgery (AOR = 3.7(1.34\u201310.1), aspiration pneumonia (AOR = 2.93(1.17\u20137.38)) and related abnormalities (AOR = 2.26(1.06\u20134.82)).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec005\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>The results of this study showed that, when compared to other studies, a substantial percentage of newborn children with esophageal atresia had poor surgical outcomes. Early surgical management, aspiration pneumonia and thrombocytopenia prevention and therapy play a big part in improving the surgical prognosis for newborns with esophageal atresia.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0285669","type":"journal-article","created":{"date-parts":[[2023,5,16]],"date-time":"2023-05-16T18:14:47Z","timestamp":1684260887000},"page":"e0285669","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":8,"title":["Surgical outcome and predictors of neonates with esophageal atresia admitted at Tikur Anbesa Specialized Hospital"],"prefix":"10.1371","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1274-5857","authenticated-orcid":true,"given":"Natnael","family":"Moges","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kassaye","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dires","family":"Birhanu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fekadesellasie","family":"Belege","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asrat","family":"Dimtse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gashaw","family":"Kerebeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Belayneh Dessie","family":"Kassa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kumlachew","family":"Geta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keder Essa","family":"Oumer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edgeit Abebe","family":"Zewde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anteneh Mengist","family":"Dessie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denekew Tenaw","family":"Anley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0537-7571","authenticated-orcid":true,"given":"Solomon","family":"Demis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fisha Alebel","family":"GebreEyesus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berihun","family":"Bantie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2023,5,16]]},"reference":[{"key":"pone.0285669.ref001","first-page":"12","volume-title":"Seminars in pediatric surgery: 2009","author":"AE Mortell","year":"2009"},{"issue":"28","key":"pone.0285669.ref002","doi-asserted-by":"crossref","first-page":"3662","DOI":"10.3748\/wjg.v18.i28.3662","article-title":"Current knowledge on esophageal atresia","volume":"18","author":"PFM Pinheiro","year":"2012","journal-title":"World journal of gastroenterology: WJG"},{"issue":"2","key":"pone.0285669.ref003","first-page":"100","volume":"11","author":"AJ Holland","year":"2010","journal-title":"Oesophageal atresia and tracheo-oesophageal fistula: current management strategies and complicationsPaediatric respiratory reviews"},{"issue":"3","key":"pone.0285669.ref004","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1136\/archdischild-2011-300597","article-title":"Oesophageal atresia: prevalence, prenatal diagnosis and associated anomalies in 23 European regions","volume":"97","author":"RN Pedersen","year":"2012","journal-title":"Archives of disease in childhood"},{"key":"pone.0285669.ref005","unstructured":"DA. 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