{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T18:13:53Z","timestamp":1793297633826,"version":"4.5.0"},"reference-count":49,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T00:00:00Z","timestamp":1684281600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Purpose<\/jats:title>\n<jats:p>To investigate the effect of change in body mass index (BMI) on intraocular pressure (IOP) in a large cohort of apparently healthy volunteers who underwent an annual comprehensive screening examinations.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>This study included individuals who were enrolled in the Tel Aviv Medical Center Inflammation Survey (TAMCIS) and had IOP and BMI measurements at their baseline and follow up visits. Relationships between BMI and IOP and the effect of change in BMI on IOP were investigated.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>A total of 7,782 individuals had at least one IOP measurement at their baseline visit, and 2,985 individuals had \u22652 visits recorded. The mean (SD) IOP (right eye) was 14.6 (2.5) mm Hg and mean (SD) BMI was 26.4 (4.1) kg\/m<jats:sup>2<\/jats:sup>. IOP positively correlated with BMI levels (r = 0.16, p&lt;0.0001). For individuals with morbid obesity (BMI\u226535 kg\/m<jats:sup>2<\/jats:sup>) and \u22652 visits, a change in BMI between the baseline and first follow-up visits correlated positively with a change in the IOP (r = 0.23, p = 0.029). Subgroup analysis of subjects who had a reduction of at least 2 BMI units showed a stronger positive correlation between change in BMI and change in IOP (r = 0.29, p&lt;0.0001). For this subgroup, a reduction of 2.86 kg\/m<jats:sup>2<\/jats:sup> of BMI was associated with a reduction of 1 mm Hg in IOP.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusions<\/jats:title>\n<jats:p>BMI loss correlated with reduction in IOP, and this correlation was more pronounced among morbidly obese individuals.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0285759","type":"journal-article","created":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T17:39:54Z","timestamp":1684345194000},"page":"e0285759","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":14,"title":["The effect of body mass index reduction on intraocular pressure in a large prospective cohort of apparently healthy individuals in Israel"],"prefix":"10.1371","volume":"18","author":[{"given":"Dan","family":"Coster","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariel","family":"Rafie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5638-1151","authenticated-orcid":true,"given":"Noam","family":"Savion-Gaiger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rony","family":"Rachmiel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shimon","family":"Kurtz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shlomo","family":"Berliner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Itzhak","family":"Shapira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Zeltser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ori","family":"Rogowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shani","family":"Shenhar-Tsarfaty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Waisbourd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2023,5,17]]},"reference":[{"issue":"9","key":"pone.0285759.ref001","doi-asserted-by":"crossref","first-page":"e888","DOI":"10.1016\/S2214-109X(17)30293-0","article-title":"Magnitude, temporal trends, and projections of the global prevalence of blindness and distance and near vision impairment: a systematic review and meta-analysis","volume":"5","author":"RRA Bourne","year":"2017","journal-title":"Lancet Glob Health"},{"issue":"11","key":"pone.0285759.ref002","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1016\/j.ophtha.2014.05.013","article-title":"Global prevalence of glaucoma and projections of glaucoma burden through 2040: a systematic review and meta-analysis","volume":"121","author":"YC Tham","year":"2014","journal-title":"Ophthalmology"},{"issue":"19","key":"pone.0285759.ref003","doi-asserted-by":"crossref","first-page":"2035","DOI":"10.1001\/jama.2013.5099","article-title":"Do Findings on Routine Examination Identify Patients at Risk for Primary Open-Angle Glaucoma?: The Rational Clinical Examination Systematic Review","volume":"309","author":"H Hollands","year":"2013","journal-title":"JAMA"},{"issue":"2","key":"pone.0285759.ref004","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1001\/jama.2020.21899","article-title":"Glaucoma in Adults-Screening, Diagnosis, and Management: A Review","volume":"325","author":"JD Stein","year":"2021","journal-title":"JAMA"},{"issue":"Suppl1","key":"pone.0285759.ref005","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/S0039-6257(03)00006-7","article-title":"Relationship between intraocular pressure and preservation of visual field in glaucoma","volume":"48","author":"I. 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