{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T20:04:42Z","timestamp":1789761882454,"version":"4.0.1"},"reference-count":20,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T00:00:00Z","timestamp":1684281600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Aims<\/jats:title>\n<jats:p>Factors underlying clinical tolerance and hemodynamic consequences of monomorphic sustained ventricular tachycardia (VT) need to be clarified.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>Intra-arterial pressures (IAP) during VT were collected in patients admitted for VT ablation and correlated to clinical, ECG and baseline echocardiographical parameters.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>114 VTs from 58 patients were included (median 67 years old, 81% ischemic heart disease, median left ventricular ejection fraction 30%). 61 VTs were untolerated needing immediate termination (54%). VT tolerance was tightly linked to the evolution of IAPs. Faster VT rates (p&lt;0.0001), presence of resynchronization therapy (p = 0.008), previous anterior myocardial infarction (p = 0.009) and more marginally larger baseline QRS duration (p = 0.1) were independently associated with VT tolerance. Only an inferior myocardial infarction was more often present in patients with only tolerated VTs vs patients with only untolerated VTs in multivariate analysis (OR 3.7, 95% CI 1.4\u20131000, p = 0.03). In patients with both well-tolerated and untolerated VTs, a higher VT rate was the only variable independently associated with untolerated VT (p = 0.02). Two different patterns of hemodynamic profiles during VT could be observed: a regular 1:1 relationship between electrical (QRS) and mechanical (IAP) events or some dissociation between both. VT with the second pattern were more often untolerated compared to the first pattern (78% vs 29%, p&lt;0.0001).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>This study helps to explain the large variability in clinical tolerance during VT, which is clearly related to IAP. VT tolerance may be linked to resynchronization therapy, VT rate, baseline QRS duration and location of myocardial infarction.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0285802","type":"journal-article","created":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T17:34:52Z","timestamp":1684344892000},"page":"e0285802","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":6,"title":["Hemodynamical consequences and tolerance of sustained ventricular tachycardia"],"prefix":"10.1371","volume":"18","author":[{"given":"Hubert","family":"Delasnerie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Biendel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meyer","family":"Elbaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franck","family":"Mandel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9897-6807","authenticated-orcid":true,"given":"Maxime","family":"Beneyto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1244-734X","authenticated-orcid":true,"given":"Guillaume","family":"Domain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quentin","family":"Voglimacci-Stephanopoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Mondoly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clement","family":"Delmas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanina","family":"Bongard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Rollin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4800-1841","authenticated-orcid":true,"given":"Philippe","family":"Maury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2023,5,17]]},"reference":[{"key":"pone.0285802.ref001","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1152\/ajplegacy.1964.206.3.547","article-title":"Effect of atrial and ventricular tachyarrhythmias on the cardiovascular dynamics","volume":"206","author":"J. Nakano","year":"1964","journal-title":"Am J Physiol"},{"key":"pone.0285802.ref002","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/0002-8703(88)90807-1","article-title":"Hemodynamic recovery during simulated ventricular tachycardia: role of adrenergic receptor activation","volume":"115","author":"T Feldman","year":"1988","journal-title":"Am Heart J"},{"key":"pone.0285802.ref003","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1161\/01.CIR.68.5.928","article-title":"Incomplete filling and incoordinate contraction as mechanisms of hypotension during ventricular tachycardia in man","volume":"68","author":"JA Lima","year":"1983","journal-title":"Circulation"},{"key":"pone.0285802.ref004","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1136\/hrt.68.10.403","article-title":"Effects of abnormal activation on the time course of the left ventricular pressure pulse in dilated cardiomyopathy","volume":"68","author":"HB Xiao","year":"1992","journal-title":"Br Heart J"},{"key":"pone.0285802.ref005","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1111\/j.1540-8159.1999.tb06810.x","article-title":"Importance of the site of ventricular tachycardia origin on left ventricular hemodynamics in humans","volume":"22","author":"TM Kolettis","year":"1999","journal-title":"Pacing Clin Electrophysiol"},{"key":"pone.0285802.ref006","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1161\/01.CIR.100.4.381","article-title":"Baroreflex gain predicts blood pressure recovery during simulated ventricular tachycardia in humans","volume":"100","author":"MH Hamdan","year":"1999","journal-title":"Circulation"},{"key":"pone.0285802.ref007","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1016\/0002-8703(94)90095-7","article-title":"Hemodynamics during ventricular tachyarrhythmias","volume":"127","author":"KK Steinbach","year":"1994","journal-title":"Am Heart J"},{"key":"pone.0285802.ref008","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/0735-1097(91)90761-W","article-title":"Sympathetic neural responses to induced ventricular tachycardia","volume":"18","author":"ML Smith","year":"1991","journal-title":"J Am Coll Cardiol"},{"key":"pone.0285802.ref009","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1161\/01.CIR.100.6.628","article-title":"Reflex control of sympathetic activity during simulated ventricular tachycardia in humans","volume":"100","author":"ML Smith","year":"1999","journal-title":"Circulation"},{"key":"pone.0285802.ref010","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1136\/heart.89.3.306","article-title":"Haemodynamic and catecholamine response to simulated ventricular tachycardia in man: effect of baseline left ventricular function.","volume":"89","author":"TM Kolettis","year":"2003","journal-title":"Heart"},{"key":"pone.0285802.ref011","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1016\/0002-8703(84)90841-X","article-title":"Factors that predict syncope during ventricular tachycardia in patients","volume":"107","author":"AW Hamer","year":"1984","journal-title":"Am Heart J"},{"key":"pone.0285802.ref012","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1111\/j.1540-8159.1984.tb04871.x","article-title":"Two dimensional echocardiographic studies during sustained ventricular tachycardia","volume":"7","author":"M Rosenbloom","year":"1984","journal-title":"Pacing Clin Electrophysiol"},{"key":"pone.0285802.ref013","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/0002-9149(64)90033-5","article-title":"Effect of pacemaker site on cardiac output and ventricular activation in dogs with complete heart block","volume":"14","author":"JW Lister","year":"1964","journal-title":"Am J Cardiol"},{"key":"pone.0285802.ref014","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1161\/01.CIR.73.4.615","article-title":"Norepinephrine spillover to plasma in patients with congestive heart failure: evidence of increased overall and cardiorenal sympathetic nervous activity","volume":"73","author":"GJ Hasking","year":"1986","journal-title":"Circulation"},{"key":"pone.0285802.ref015","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1172\/JCI114294","article-title":"Decreased adrenergic neuronal uptake activity in experimental right heart failure. 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