{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T03:16:29Z","timestamp":1783480589347,"version":"3.55.0"},"reference-count":65,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2023,5,25]],"date-time":"2023-05-25T00:00:00Z","timestamp":1684972800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>The joint work of the stomach and the small intestine plays a fundamental role in human digestion. In the stomach, food is turned into a semi-fluid mixture that is slowly released into the small intestine, where most enzymatic reactions occur, and nutrients are absorbed as they become available. This whole process is closely related to glucose homeostasis, mainly because of the appearance of glucose in the portal system and the energetic expenditure of the process itself. The current phenomenological-based model describes such effects of the digestive process on blood glucose concentration. It considers enzymatic and mechanical transformations, energetic expenditure, and the impact of macro-nutrients, fiber, and water on overall digestion and glucose absorption. The model estimates the rate of glucose appearance in the portal vein and is intended to be further integrated into existing models for other human organs and used in model-based systems such as an artificial pancreas with automated insulin delivery.<\/jats:p>","DOI":"10.1371\/journal.pone.0285849","type":"journal-article","created":{"date-parts":[[2023,5,25]],"date-time":"2023-05-25T17:24:13Z","timestamp":1685035453000},"page":"e0285849","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":4,"title":["Estimation of glucose rate of appearance in portal vein circulation using a phenomenological-based model"],"prefix":"10.1371","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6745-3571","authenticated-orcid":true,"given":"Laura","family":"Lema-Perez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Herr\u00f3n-Bedoya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Paredes-\u00c1ngel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Hern\u00e1ndez-Arango","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2418-6159","authenticated-orcid":true,"given":"Carlos E.","family":"Builes-Monta\u00f1o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hernan","family":"Alvarez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2023,5,25]]},"reference":[{"issue":"3","key":"pone.0285849.ref001","doi-asserted-by":"crossref","first-page":"E214","DOI":"10.1152\/ajpendo.1979.237.3.E214","article-title":"Glucose clamp technique: a method for quantifying insulin secretion and resistance","volume":"237","author":"Ralph A DeFronzo","year":"1979","journal-title":"American Journal of Physiology-Endocrinology And Metabolism"},{"issue":"6","key":"pone.0285849.ref002","doi-asserted-by":"crossref","first-page":"E667","DOI":"10.1152\/ajpendo.1979.236.6.E667","article-title":"Quantitative estimation of insulin sensitivity","volume":"236","author":"Richard N Bergman","year":"1979","journal-title":"American Journal of Physiology-Endocrinology And Metabolism"},{"issue":"2","key":"pone.0285849.ref003","doi-asserted-by":"crossref","first-page":"94","DOI":"10.2337\/diab.22.2.94","article-title":"Modeling blood glucose and insulin kinetics in normal, diabetic and obese subjects","volume":"22","author":"G Segre","year":"1973","journal-title":"Diabetes"},{"issue":"3","key":"pone.0285849.ref004","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/0141-5425(92)90058-S","article-title":"A physiological model of glucose-insulin interaction in type 1 diabetes mellitus","volume":"14","author":"ED Lehmann","year":"1992","journal-title":"Journal of biomedical engineering"},{"issue":"2","key":"pone.0285849.ref005","first-page":"292","article-title":"Relationships between gastric emptying of solid and caloric liquid meals and alcohol absorption","volume":"257","author":"M. Horowitz","year":"1989","journal-title":"Am J Physiol"},{"issue":"12","key":"pone.0285849.ref006","doi-asserted-by":"crossref","first-page":"2472","DOI":"10.1109\/TBME.2006.883792","article-title":"A system model of oral glucose absorption: validation on gold standard data","volume":"53","author":"Chiara Dalla Man","year":"2006","journal-title":"IEEE Transactions on Biomedical Engineering"},{"issue":"10","key":"pone.0285849.ref007","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.1109\/TBME.2007.893506","article-title":"Meal simulation model of the glucose-insulin system","volume":"54","author":"Chiara Dalla Man","year":"2007","journal-title":"IEEE Transactions on biomedical engineering"},{"issue":"36029","key":"pone.0285849.ref008","volume":"6","author":"Luca Marchetti","year":"2016","journal-title":"A Novel Insulin\/Glucose Model after a Mixed-Meal Test in Patients with Type 1 Diabetes on Insulin Pump Therapy"},{"issue":"2","key":"pone.0285849.ref009","article-title":"A closed-loop multi-level model of glucose homeostasis","volume":"13","author":"Cansu Uluseker","year":"2018","journal-title":"PloS one"},{"key":"pone.0285849.ref010","article-title":"Modelo Matem\u00e1tico de un Paciente con Diabetes Tipo 1 en Lazo Cerrado","author":"Juliana Manrique Cordoba","year":"2020","journal-title":"Revista Iberoamericana de Autom\u00e1tica e Inform\u00e1tica industrial"},{"key":"pone.0285849.ref011","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.jtbi.2018.10.024","article-title":"Phenomenological-Based model of human stomach and its role in glucose metabolism","volume":"460","author":"Laura Lema-Perez","year":"2019","journal-title":"Journal of theoretical biology"},{"key":"pone.0285849.ref012","doi-asserted-by":"crossref","unstructured":"Bland\u00f3n, Laura Alzate and Gallego, Maria Salom\u00e9i Cardona and Patino, Sara Isabel Ospina and P\u00e9rez, Laura Lema. A Phenomenological-Based Model for the Small Intestine Role in Human Glucose Homeostasis. IEEE 4th Colombian Conference on Automatic Control (CCAC). 2019; p:1\u20136","DOI":"10.1109\/CCAC.2019.8920843"},{"key":"pone.0285849.ref013","doi-asserted-by":"crossref","first-page":"100158","DOI":"10.1016\/j.imu.2019.02.002","article-title":"On parameter interpretability of phenomenological-based semiphysical models in biology","volume":"15","author":"Laura Lema-Perez","year":"2019","journal-title":"Informatics in Medicine Unlocked"},{"issue":"3","key":"pone.0285849.ref014","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/S1697-7912(09)70262-6","article-title":"Dise\u00f1o simult\u00e1neo de proceso y control de una torre sulfitadora de jugo de cana de az\u00facar","volume":"6","author":"Rosalba Lamanna","year":"2009","journal-title":"Revista Iberoamericana de Autom\u00e1tica e Inform\u00e1tica Industrial RIAI"},{"key":"pone.0285849.ref015","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.matdes.2016.09.009","article-title":"A phenomenologically based material flow model for friction stir welding","volume":"111","author":"E. Hoyos","year":"2016","journal-title":"Materials and Design"},{"key":"pone.0285849.ref016","article-title":"An Introduction to Nutrition","author":"Maureen Zimmerman","year":"2012","journal-title":"Creative Commons"},{"issue":"6","key":"pone.0285849.ref017","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1136\/gut.32.6.615","article-title":"Role of the proximal and distal stomach in mixed solid and liquid meal emptying","volume":"32","author":"P. J. Collins","year":"1991","journal-title":"Gut"},{"issue":"6","key":"pone.0285849.ref018","doi-asserted-by":"crossref","first-page":"2062","DOI":"10.1210\/jc.2005-2644","article-title":"Effects of fat on gastric emptying of and the glycemic, insulin, and incretin responses to a carbohydrate meal in type 2 diabetes","volume":"91","author":"Diana Gentilcore","year":"2006","journal-title":"The Journal of Clinical Endocrinology & Metabolism"},{"key":"pone.0285849.ref019","first-page":"959","article-title":"Physiology of the Gastrointestinal Tract","volume":"1","author":"Christopher K. Rayner","year":"2012","journal-title":"Physiology of the Antral Pump and Gastric Emptying"},{"issue":"6","key":"pone.0285849.ref020","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1093\/bjaceaccp\/mkp033","article-title":"Practical gastric physiology","volume":"9","author":"Diana M. Jolliffe","year":"2009","journal-title":"Continuing Education in Anaesthesia, Critical Care & Pain"},{"issue":"6","key":"pone.0285849.ref021","doi-asserted-by":"crossref","first-page":"884","DOI":"10.2337\/dc16-0351","article-title":"Roles of the gut in glucose homeostasis","volume":"39","author":"Jens Juul Holst","year":"2016","journal-title":"Diabetes Care"},{"issue":"2","key":"pone.0285849.ref022","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0016-5085(76)80010-8","article-title":"Measurement of gastric functions during digestion of ordinary solid meals in man","volume":"70","author":"Juan-R Malagelada","year":"1976","journal-title":"Gastroenterology"},{"issue":"3","key":"pone.0285849.ref023","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/S1369-7021(11)70059-1","article-title":"Characterizing the elastic properties of tissues","volume":"14","author":"Riaz Akhtar","year":"2011","journal-title":"Materials Today"},{"key":"pone.0285849.ref024","volume-title":"Human Anatomy and Physiology","author":"B. Cummings","year":"2001"},{"issue":"1","key":"pone.0285849.ref025","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s10409-018-0809-5","article-title":"Effect of local longitudinal shortening on the transport of luminal contents through small intestine","volume":"35","author":"Ravi Kant Avvari","year":"2019","journal-title":"Acta Mechanica Sinica\/Lixue Xuebao"},{"issue":"2","key":"pone.0285849.ref026","doi-asserted-by":"crossref","first-page":"1931","DOI":"10.1053\/gast.2002.37062","article-title":"The high metabolic cost of a functional gut","volume":"123","author":"Sophie R.D. Van der Schoor","year":"2002","journal-title":"Gastroenterology"},{"key":"pone.0285849.ref027","unstructured":"Green, D W and Perry, R H Professional, McGraw Hill McGraw-Hill Education McGraw Hill professional Perry\u2019s Chemical Engineers\u2019 Handbook, Eighth Edition 2007"},{"key":"pone.0285849.ref028","unstructured":"Hangos, K. M. and Cameron, I. T. 0-12-156931-4 Academic Press Process Modelling and Model Analysis 2001"},{"issue":"8","key":"pone.0285849.ref029","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1016\/j.jmbbm.2011.05.030","article-title":"Biaxial mechanical modeling of the small intestine","volume":"4","author":"Chiara Bellini","year":"2011","journal-title":"Journal of the Mechanical Behavior of Biomedical Materials"},{"key":"pone.0285849.ref030","first-page":"3","article-title":"Biomechanics of Living Organs: Hyperelastic Constitutive Laws for Finite Element Modeling","author":"Gr\u00e9gory Chagnon","year":"2017","journal-title":"Hyperelasticity Modeling for Incompressible Passive Biological Tissues"},{"issue":"44","key":"pone.0285849.ref031","doi-asserted-by":"crossref","first-page":"11144","DOI":"10.1073\/pnas.1814392115","article-title":"Relation between blood pressure and pulse wave velocity for human arteries","volume":"115","author":"Yinji Ma","year":"2018","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"2","key":"pone.0285849.ref032","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.ejrad.2009.04.066","article-title":"Normal small bowel wall characteristics on MR enterography","volume":"75","author":"Carmel G. Cronin","year":"2009","journal-title":"European Journal of Radiology"},{"issue":"7","key":"pone.0285849.ref033","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1002\/ca.22238","article-title":"Intraoperative small bowel length measurements and analysis of demographic predictors of increased length","volume":"26","author":"Ezra N. Teitelbaum","year":"2013","journal-title":"Clinical Anatomy"},{"issue":"1","key":"pone.0285849.ref034","doi-asserted-by":"crossref","first-page":"39","DOI":"10.3109\/00365529709025061","article-title":"Large-scale ambulatory study of postprandial jejunal motility in irritable bowel syndrome","volume":"32","author":"P. K. Small","year":"1997","journal-title":"Scandinavian Journal of Gastroenterology"},{"issue":"8","key":"pone.0285849.ref035","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1016\/j.cellsig.2009.02.011","article-title":"The effects of mechanical forces on intestinal physiology and pathology","volume":"21","author":"Christopher P. Gayer","year":"2009","journal-title":"Cellular Signalling"},{"key":"pone.0285849.ref036","volume-title":"Biomedical Engineering","author":"Joseph J. Feher","year":"2017","edition":"2"},{"issue":"2","key":"pone.0285849.ref037","doi-asserted-by":"crossref","DOI":"10.1159\/000201097","article-title":"Fate of Pancreatic Enzymes in the Human Intestinal Lumen in Health and Pancreatic Insufficiency","volume":"54","author":"P. Layer","year":"1993","journal-title":"Digestion"},{"issue":"2","key":"pone.0285849.ref038","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/1550-2783-1-2-27","article-title":"The Role of Dietary Protein Intake and Resistance Training on Myosin Heavy Chain Expression","volume":"1","author":"Colin D Wilborn","year":"2004","journal-title":"Journal of the International Society of Sports Nutrition"},{"issue":"22","key":"pone.0285849.ref039","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1021\/ja01515a026","article-title":"The Molecular Weight, Size and Shape of the Myosin Molecule","volume":"81","author":"Alfred Holtzer","year":"1959","journal-title":"Journal of the American Chemical Society"},{"issue":"9","key":"pone.0285849.ref040","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1007\/s00424-020-02439-5","article-title":"Glucose transporters in the small intestine in health and disease","volume":"472","author":"Hermann Koepsell","year":"2020","journal-title":"Pflugers Archiv European Journal of Physiology"},{"issue":"1","key":"pone.0285849.ref041","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1042\/bj3500155","article-title":"The diffusive component of intestinal glucose absorption is mediated by the glucose-induced recruitment of GLUT2 to the brush-border membrane","volume":"350","author":"G. L. Kellett","year":"2000","journal-title":"Biochemical Journal"},{"issue":"3","key":"pone.0285849.ref042","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1111\/j.1469-7793.2001.0585h.x","article-title":"The facilitated component of intestinal glucose absorption","volume":"531","author":"G. L Kellett","year":"2001","journal-title":"Journal of Physiology"},{"issue":"2","key":"pone.0285849.ref043","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1159\/000199581","article-title":"The kinetics of monosaccharide absorption by human jejunal biopsies: Evidence for active and passive processes","volume":"38","author":"D. J. Dawson","year":"1987","journal-title":"Digestion"},{"issue":"10","key":"pone.0285849.ref044","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/j.tibs.2018.05.003","article-title":"Amino acid transporters revisited: New views in health and disease","volume":"43","author":"Palanivel Kandasamy","year":"2018","journal-title":"Trends in Biochemical Sciences"},{"issue":"9","key":"pone.0285849.ref045","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1172\/JCI105451","article-title":"Absorption of glycine and L-alanine by the human jejunum","volume":"45","author":"B. Fleshler","year":"1966","journal-title":"The Journal of Clinical Investigation"},{"issue":"3","key":"pone.0285849.ref046","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1111\/eci.12161","article-title":"New insights into the molecular mechanism of intestinal fatty acid absorption","volume":"43","author":"Tony Y Wang","year":"2013","journal-title":"European Journal of Clinical Investigation"},{"issue":"1","key":"pone.0285849.ref047","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0022-5193(70)90126-8","article-title":"Formal kinetics of water and solute absorption with regard to intestinal blood flow","volume":"27","author":"D. Winne","year":"1970","journal-title":"Journal of Theoretical Biology"},{"issue":"5","key":"pone.0285849.ref048","doi-asserted-by":"crossref","first-page":"2142","DOI":"10.1152\/jappl.1992.73.5.2142","article-title":"Intestinal water absorption from select carbohydrate solutions in humans","volume":"73","author":"C. V. Gisolfi","year":"1992","journal-title":"Journal of Applied Physiology"},{"issue":"6","key":"pone.0285849.ref049","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.mpsur.2009.03.003","article-title":"Digestion and absorption","volume":"27","author":"Anthony D. Jackson","year":"2009","journal-title":"Surgery (Oxford)"},{"issue":"6","key":"pone.0285849.ref050","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1136\/gut.2005.065946","article-title":"Human pancreatic exocrine response to nutrients in health and disease","volume":"54","author":"J. Keller","year":"2005","journal-title":"Gut"},{"issue":"1","key":"pone.0285849.ref051","first-page":"1","article-title":"Modelamiento de Sistemas de Inferencia Borrosa Tipo Takagi\u2014Sugeno","author":"Hern\u00e1n Alvarez","year":"2004","journal-title":"Avances en Sistemas e Informatica"},{"issue":"1","key":"pone.0285849.ref052","first-page":"1","article-title":"Colloquium Series on Integrated Systems Physiology: From Molecule to Function","volume":"1","author":"Stephen J Pandol","year":"2011","journal-title":"The Exocrine Pancreas"},{"issue":"11","key":"pone.0285849.ref053","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1136\/gut.32.11.1406","article-title":"Gall bladder emptying patterns in response to a normal meal in healthy subjects and patients with gall stones: Ultrasound study","volume":"32","author":"P. J Howard","year":"1991","journal-title":"Gut"},{"issue":"8","key":"pone.0285849.ref054","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1016\/j.medengphy.2011.12.006","article-title":"Computational analysis of the flow of bile in human cystic duct","volume":"34","author":"Mushtak Al-Atabi","year":"2012","journal-title":"Medical Engineering and Physics"},{"issue":"1","key":"pone.0285849.ref055","doi-asserted-by":"crossref","first-page":"74","DOI":"10.3109\/00365528909092242","article-title":"Fat and pancreatic secretion","volume":"24","author":"O. Olsen","year":"1989","journal-title":"Scandinavian Journal of Gastroenterology"},{"issue":"3","key":"pone.0285849.ref056","doi-asserted-by":"crossref","first-page":"E483","DOI":"10.1152\/ajpendo.00133.2019","article-title":"A novel natural tracer method to measure complex carbohydrate metabolism","volume":"317","author":"Rita Basu","year":"2019","journal-title":"American Journal of Physiology\u2014Endocrinology and Metabolism"},{"issue":"4","key":"pone.0285849.ref057","doi-asserted-by":"crossref","first-page":"E637","DOI":"10.1152\/ajpendo.00319.2003","article-title":"Minimal model estimation of glucose absorption and insulin sensitivity from oral test: validation with a tracer method","volume":"287","author":"Chiara Dalla Man","year":"2004","journal-title":"American Journal of Physiology-Endocrinology and Metabolism"},{"issue":"6","key":"pone.0285849.ref058","doi-asserted-by":"crossref","first-page":"580","DOI":"10.2337\/diab.34.6.580","article-title":"The disposal of an oral glucose load in healthy subjects. A quantitative study","volume":"34","author":"E. Ferrannini","year":"1985","journal-title":"Diabetes"},{"issue":"7","key":"pone.0285849.ref059","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.cupe.2004.08.004","article-title":"Digestion and absorption","volume":"14","author":"A. Hinsberger","year":"2004","journal-title":"Current Paediatrics"},{"issue":"6","key":"pone.0285849.ref060","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1016\/0016-5085(79)90410-4","article-title":"Protein digestion and absorption in human small intestine","volume":"76","author":"Yoon Chul Chung","year":"1979","journal-title":"Gastroenterology"},{"issue":"2","key":"pone.0285849.ref061","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1177\/0884533611436116","article-title":"Effects of gut microbes on nutrient absorption and energy regulation","volume":"27","author":"Rosa Krajmalnik-Brown","year":"2012","journal-title":"Nutrition in Clinical Practice"},{"issue":"1","key":"pone.0285849.ref062","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1080\/00365521.1975.12096920","article-title":"Studies of gastrointestinal interactions. VII. Characteristics of the absorption pattern of sugar, fat and protein from composite meals in man. A quantitative study","volume":"10","author":"C Johansson","year":"1975","journal-title":"Scandinavian Journal of Gastroenterology"},{"issue":"5","key":"pone.0285849.ref063","doi-asserted-by":"crossref","first-page":"R67","DOI":"10.1111\/j.1750-3841.2008.00766.x","article-title":"Disintegration of Solid Foods in Human Stomach","volume":"73","author":"F. Kong","year":"2008","journal-title":"Journal of Food Science"},{"issue":"4","key":"pone.0285849.ref064","article-title":"STUDIA: An application to support carbohydrate counting by simulating glucose dynamics","volume":"9","author":"Carlos E. Builes-Monta\u00f1o","year":"2022","journal-title":"Revista colombiana de Endocrinolog\u00eda, Diabetes Metabolismo"},{"key":"pone.0285849.ref065","doi-asserted-by":"crossref","first-page":"105232","DOI":"10.1016\/j.compbiomed.2022.105232","article-title":"Main glucose hepatic fluxes in healthy subjects predicted from a phenomenological-based model","volume":"142","author":"Carlos E. Builes-Monta\u00f1o","year":"2022","journal-title":"Computers in Biology and Medicine"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0285849","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,14]],"date-time":"2023-12-14T01:55:36Z","timestamp":1702518936000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0285849"}},"subtitle":[],"editor":[{"given":"Juan J","family":"Loor","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2023,5,25]]},"references-count":65,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2023,5,25]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0285849","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,25]]}}}