{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T19:40:28Z","timestamp":1789501228271,"version":"build-2803163510"},"reference-count":83,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2023,11,3]],"date-time":"2023-11-03T00:00:00Z","timestamp":1698969600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100013386","name":"Virginia Mason Medical Center","doi-asserted-by":"publisher","award":["Pioneer Award"],"award-info":[{"award-number":["Pioneer Award"]}],"id":[{"id":"10.13039\/100013386","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Mucosal-Associated Invariant T (MAIT) cells are T cells with a semi-invariant T cell receptor (TCR), recognizing riboflavin precursors presented by a non-polymorphic MR1 molecule. As these precursors are produced by the gut microbiome, we characterized the frequency, phenotype and clonality of MAIT cells in human colons with and without Crohn\u2019s disease (CD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The transcriptome of MAIT cells sorted from blood and intestinal lamina propria cells from colectomy recipients were compared with other CD8\n                      <jats:sup>+<\/jats:sup>\n                      T cells. Colon biopsies from an additional ten CD patients and ten healthy controls (HC) were analyzed by flow cytometry. TCR genes were sequenced from individual MAIT cells from these biopsies and compared with those of MAIT cells from autologous blood.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>MAIT cells in the blood and colon showed a transcriptome distinct from other CD8 T cells, with more expression of the IL-23 receptor. MAIT cells were enriched in the colons of CD patients, with less NKG2D in inflamed versus uninflamed segments. Regardless of disease, most MAIT cells expressed integrin \u03b14\u03b27 in the colon but not in the blood, where they were enriched for \u03b14\u03b27 expression. TCR sequencing revealed heterogeneity in the colon and blood, with few public sequences associated with cohorts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>MAIT cells are enriched in the colons of CD patients and disproportionately express molecules (IL-23R, integrin \u03b14\u03b27) targeted by CD therapeutics, to suggest a pathogenic role for them in CD. Public TCR sequences were neither common nor sufficiently restricted to a cohort to suggest protective or pathogenic antigen-specificities.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0285918","type":"journal-article","created":{"date-parts":[[2023,11,3]],"date-time":"2023-11-03T13:26:20Z","timestamp":1699017980000},"page":"e0285918","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":3,"title":["Colonic mucosal associated invariant T cells in Crohn\u2019s disease have a diverse and non-public T cell receptor beta chain repertoire"],"prefix":"10.1371","volume":"18","author":[{"given":"Andrew J.","family":"Konecny","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donna M.","family":"Shows","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8961-3660","authenticated-orcid":true,"given":"James D.","family":"Lord","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2023,11,3]]},"reference":[{"issue":"7","key":"pone.0285918.ref001","doi-asserted-by":"crossref","first-page":"3006","DOI":"10.1073\/pnas.0914839107","article-title":"Analysis of CD161 expression on human CD8+ T cells defines a distinct functional subset with tissue-homing properties","volume":"107","author":"E Billerbeck","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5","key":"pone.0285918.ref002","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1111\/imcb.12021","article-title":"Human blood MAIT cell subsets defined using MR1 tetramers","volume":"96","author":"NA Gherardin","year":"2018","journal-title":"Immunol Cell Biol"},{"issue":"12","key":"pone.0285918.ref003","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1084\/jem.189.12.1907","article-title":"An invariant T cell receptor alpha chain defines a novel TAP-independent major histocompatibility complex class Ib-restricted alpha\/beta T cell subpopulation in mammals","volume":"189","author":"F Tilloy","year":"1999","journal-title":"J Exp Med"},{"issue":"1","key":"pone.0285918.ref004","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1084\/jem.178.1.1","article-title":"Analysis of T cell antigen receptor (TCR) expression by human peripheral blood CD4-8- alpha\/beta T cells demonstrates preferential use of several V beta genes and an invariant TCR alpha chain.","volume":"178","author":"S Porcelli","year":"1993","journal-title":"J Exp 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Treiner","year":"2003","journal-title":"Nature"},{"issue":"4","key":"pone.0285918.ref008","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1182\/blood-2010-08-303339","article-title":"Human MAIT cells are xenobiotic-resistant, tissue-targeted, CD161hi IL-17-secreting T cells","volume":"117","author":"M Dusseaux","year":"2011","journal-title":"Blood"},{"key":"pone.0285918.ref009","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.3389\/fimmu.2017.01252","article-title":"IL-17 Production from T Helper 17, Mucosal-Associated Invariant T, and gammadelta Cells in Tuberculosis Infection and Disease.","volume":"8","author":"F Coulter","year":"2017","journal-title":"Front Immunol"},{"issue":"6","key":"pone.0285918.ref010","doi-asserted-by":"crossref","first-page":"e1000407","DOI":"10.1371\/journal.pbio.1000407","article-title":"Human mucosal associated invariant T cells detect bacterially infected cells","volume":"8","author":"MC Gold","year":"2010","journal-title":"PLoS 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Immunol"},{"issue":"5","key":"pone.0285918.ref016","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1053\/j.gastro.2017.07.043","article-title":"Intra-Hepatic Depletion of Mucosal-Associated Invariant T Cells in Hepatitis C Virus-Induced Liver Inflammation","volume":"153","author":"O Bolte FJ","year":"2017","journal-title":"Gastroenterology"},{"issue":"2","key":"pone.0285918.ref017","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1007\/s00134-013-3163-x","article-title":"Specific MAIT cell behaviour among innate-like T lymphocytes in critically ill patients with severe infections","volume":"40","author":"D Grimaldi","year":"2014","journal-title":"Intensive Care Med"},{"issue":"2","key":"pone.0285918.ref018","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1111\/cei.13377","article-title":"Mucosal-associated invariant T cells and Vdelta2(+) gammadelta T cells in community acquired pneumonia: association of abundance in sputum with clinical severity and outcome.","volume":"199","author":"RF Hannaway","year":"2020","journal-title":"Clin Exp Immunol"},{"issue":"9","key":"pone.0285918.ref019","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1093\/intimm\/dxr047","article-title":"Mucosal-associated invariant T cells regulate Th1 response in multiple sclerosis","volume":"23","author":"Y Miyazaki","year":"2011","journal-title":"Int Immunol"},{"issue":"8","key":"pone.0285918.ref020","doi-asserted-by":"crossref","first-page":"e105375","DOI":"10.1371\/journal.pone.0105375","article-title":"In situ characterization of intrahepatic non-parenchymal cells in PSC reveals phenotypic patterns associated with disease severity.","volume":"9","author":"L Berglin","year":"2014","journal-title":"PLoS One."},{"issue":"10","key":"pone.0285918.ref021","doi-asserted-by":"crossref","first-page":"2444","DOI":"10.1002\/eji.201646300","article-title":"Mucosal-associated invariant T cells are reduced and functionally immature in the peripheral blood of primary Sjogren\u2019s syndrome patients","volume":"46","author":"JJ Wang","year":"2016","journal-title":"Eur J Immunol"},{"issue":"5","key":"pone.0285918.ref022","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.cytogfr.2010.08.002","article-title":"Interleukin-22: a cytokine produced by T, NK and NKT cell subsets, with importance in the innate immune defense and tissue protection","volume":"21","author":"E Witte","year":"2010","journal-title":"Cytokine Growth Factor Rev"},{"issue":"4","key":"pone.0285918.ref023","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1172\/JCI78941","article-title":"Mucosal-associated invariant T cell alterations in obese and type 2 diabetic patients","volume":"125","author":"I Magalhaes","year":"2015","journal-title":"J Clin Invest"},{"issue":"12","key":"pone.0285918.ref024","doi-asserted-by":"crossref","first-page":"5775","DOI":"10.4049\/jimmunol.1402945","article-title":"Altered distribution and increased IL-17 production by mucosal-associated invariant T cells in adult and childhood obesity","volume":"194","author":"E Carolan","year":"2015","journal-title":"J Immunol"},{"issue":"10","key":"pone.0285918.ref025","doi-asserted-by":"crossref","first-page":"e76008","DOI":"10.1371\/journal.pone.0076008","article-title":"Persistent changes in circulating and intestinal gammadelta T cell subsets, invariant natural killer T cells and mucosal-associated invariant T cells in children and adults with coeliac disease.","volume":"8","author":"MR Dunne","year":"2013","journal-title":"PLoS One."},{"issue":"7","key":"pone.0285918.ref026","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1097\/MIB.0000000000000397","article-title":"Reduced Numbers and Proapoptotic Features of Mucosal-associated Invariant T Cells as a Characteristic Finding in Patients with Inflammatory Bowel Disease.","volume":"21","author":"E Hiejima","year":"2015","journal-title":"Inflamm Bowel Dis."},{"issue":"5","key":"pone.0285918.ref027","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1111\/jgh.13242","article-title":"MAIT cells are activated and accumulated in the inflamed mucosa of ulcerative colitis","volume":"31","author":"K Haga","year":"2016","journal-title":"J Gastroenterol Hepatol"},{"issue":"2","key":"pone.0285918.ref028","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1111\/cei.12277","article-title":"Innate mucosal-associated invariant T (MAIT) cells are activated in inflammatory bowel diseases.","volume":"176","author":"NE Serriari","year":"2014","journal-title":"Clin Exp Immunol"},{"issue":"2","key":"pone.0285918.ref029","doi-asserted-by":"crossref","first-page":"111","DOI":"10.2220\/biomedres.38.111","article-title":"Possible involvement of mucosal-associated invariant T cells in the progression of inflammatory bowel diseases","volume":"38","author":"K Tominaga","year":"2017","journal-title":"Biomed Res"},{"issue":"10","key":"pone.0285918.ref030","doi-asserted-by":"crossref","first-page":"3119","DOI":"10.1002\/eji.201344160","article-title":"CD8(+) MAIT cells infiltrate into the CNS and alterations in their blood frequencies correlate with IL-18 serum levels in multiple sclerosis.","volume":"44","author":"A Willing","year":"2014","journal-title":"Eur J Immunol"},{"key":"pone.0285918.ref031","first-page":"166","article-title":"Neuropathologic, phenotypic and functional analyses of Mucosal Associated Invariant T cells in Multiple Sclerosis","author":"M Salou","year":"2016","journal-title":"Clin Immunol"},{"issue":"Pt 2","key":"pone.0285918.ref032","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1093\/brain\/awq354","article-title":"CD161(high)CD8+T cells bear pathogenetic potential in multiple sclerosis.","volume":"134","author":"V Annibali","year":"2011","journal-title":"Brain"},{"issue":"Pt 9","key":"pone.0285918.ref033","doi-asserted-by":"crossref","first-page":"2888","DOI":"10.1093\/brain\/awt182","article-title":"Non-myeloablative autologous haematopoietic stem cell transplantation expands regulatory cells and depletes IL-17 producing mucosal-associated invariant T cells in multiple sclerosis","volume":"136","author":"SV Abrahamsson","year":"2013","journal-title":"Brain"},{"issue":"1","key":"pone.0285918.ref034","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S0046-8177(75)80107-9","article-title":"Inflammatory bowel disease: the surgical pathology of Crohn\u2019s disease and ulcerative colitis.","volume":"6","author":"AB Price","year":"1975","journal-title":"Hum Pathol"},{"key":"pone.0285918.ref035","first-page":"35","article-title":"Why does tumor necrosis factor targeted therapy reactivate tuberculosis?","volume":"74","author":"S. Ehlers","year":"2005","journal-title":"J Rheumatol Suppl"},{"issue":"2","key":"pone.0285918.ref036","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1007\/s10620-020-06653-0","article-title":"Putting Crohn\u2019s on the MAP: Five Common Questions on the Contribution of Mycobacterium avium subspecies paratuberculosis to the Pathophysiology of Crohn\u2019s Disease.","volume":"66","author":"G Agrawal","year":"2021","journal-title":"Dig Dis Sci"},{"issue":"7422","key":"pone.0285918.ref037","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/nature11582","article-title":"Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease","volume":"491","author":"L Jostins","year":"2012","journal-title":"Nature"},{"issue":"8","key":"pone.0285918.ref038","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1136\/gut.2008.163667","article-title":"Crohn\u2019s disease: Th1, Th17 or both? The change of a paradigm: new immunological and genetic insights implicate Th17 cells in the pathogenesis of Crohn\u2019s disease","volume":"58","author":"S. Brand","year":"2009","journal-title":"Gut"},{"key":"pone.0285918.ref039","doi-asserted-by":"crossref","first-page":"928461","DOI":"10.1155\/2014\/928461","article-title":"Role of Th17 Cells in the Pathogenesis of Human IBD","volume":"2014","author":"J. Galvez","year":"2014","journal-title":"ISRN Inflamm."},{"issue":"3","key":"pone.0285918.ref040","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/s00281-019-00733-8","article-title":"The pathogenicity of Th17 cells in autoimmune diseases.","volume":"41","author":"K Yasuda","year":"2019","journal-title":"Semin Immunopathol"},{"issue":"1","key":"pone.0285918.ref041","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1007\/s11684-015-0388-9","article-title":"Th17 cells in autoimmune diseases.","volume":"9","author":"L Han","year":"2015","journal-title":"Front Med"},{"issue":"1","key":"pone.0285918.ref042","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.ajpath.2012.03.044","article-title":"Th17 cells: biology, pathogenesis of autoimmune and inflammatory diseases, and therapeutic strategies","volume":"181","author":"MS Maddur","year":"2012","journal-title":"Am J Pathol"},{"issue":"20","key":"pone.0285918.ref043","doi-asserted-by":"crossref","first-page":"8290","DOI":"10.1073\/pnas.0903196106","article-title":"MR1 antigen presentation to mucosal-associated invariant T cells was highly conserved in evolution","volume":"106","author":"S Huang","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"11","key":"pone.0285918.ref044","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1038\/ni.3565","article-title":"A three-stage intrathymic development pathway for the mucosal-associated invariant T cell lineage","volume":"17","author":"HF Koay","year":"2016","journal-title":"Nat Immunol"},{"issue":"11","key":"pone.0285918.ref045","doi-asserted-by":"crossref","first-page":"5438","DOI":"10.4049\/jimmunol.1103801","article-title":"Human Th17 cells express high levels of enzymatically active dipeptidylpeptidase IV (CD26).","volume":"188","author":"B Bengsch","year":"2012","journal-title":"J Immunol"},{"issue":"4","key":"pone.0285918.ref046","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1111\/sji.12467","article-title":"Analysis of the Phenotype and Function of the Subpopulations of Mucosal-Associated Invariant T Cells","volume":"84","author":"J Brozova","year":"2016","journal-title":"Scand J Immunol"},{"issue":"1","key":"pone.0285918.ref047","doi-asserted-by":"crossref","first-page":"107","DOI":"10.4049\/jimmunol.1601989","article-title":"Controlled Human Malaria Infection Leads to Long-Lasting Changes in Innate and Innate-like Lymphocyte Populations","volume":"199","author":"M Mpina","year":"2017","journal-title":"J Immunol"},{"key":"pone.0285918.ref048","doi-asserted-by":"crossref","first-page":"3143","DOI":"10.1038\/ncomms4143","article-title":"Acquisition of innate-like microbial reactivity in mucosal tissues during human fetal MAIT-cell development","volume":"5","author":"E Leeansyah","year":"2014","journal-title":"Nat Commun"},{"issue":"19","key":"pone.0285918.ref049","doi-asserted-by":"crossref","first-page":"3167","DOI":"10.1200\/JCO.2009.26.7609","article-title":"Phase I study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: safety, clinical activity, pharmacodynamics, and immunologic correlates.","volume":"28","author":"JR Brahmer","year":"2010","journal-title":"J Clin Oncol"},{"issue":"8","key":"pone.0285918.ref050","doi-asserted-by":"crossref","first-page":"e1005072","DOI":"10.1371\/journal.ppat.1005072","article-title":"Arming of MAIT Cell Cytolytic Antimicrobial Activity Is Induced by IL-7 and Defective in HIV-1 Infection.","volume":"11","author":"E Leeansyah","year":"2015","journal-title":"PLoS Pathog."},{"issue":"7","key":"pone.0285918.ref051","doi-asserted-by":"crossref","first-page":"3142","DOI":"10.4049\/jimmunol.1203218","article-title":"IL-7 licenses activation of human liver intrasinusoidal mucosal-associated invariant T cells","volume":"190","author":"XZ Tang","year":"2013","journal-title":"J Immunol"},{"issue":"1","key":"pone.0285918.ref052","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1002\/eji.201343509","article-title":"CD161++ CD8+ T cells, including the MAIT cell subset, are specifically activated by IL-12+IL-18 in a TCR-independent manner","volume":"44","author":"JE Ussher","year":"2014","journal-title":"Eur J Immunol"},{"issue":"8","key":"pone.0285918.ref053","doi-asserted-by":"crossref","first-page":"2286","DOI":"10.1002\/eji.201445313","article-title":"IL-15 dependent induction of IL-18 secretion as a feedback mechanism controlling human MAIT-cell effector functions","volume":"45","author":"A Sattler","year":"2015","journal-title":"Eur J Immunol"},{"issue":"9","key":"pone.0285918.ref054","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1038\/ni1488","article-title":"IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways.","volume":"8","author":"L Zhou","year":"2007","journal-title":"Nat Immunol"},{"issue":"6","key":"pone.0285918.ref055","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.smim.2007.10.012","article-title":"The link between IL-23 and Th17 cell-mediated immune pathologies.","volume":"19","author":"MJ McGeachy","year":"2007","journal-title":"Semin Immunol."},{"issue":"5804","key":"pone.0285918.ref056","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1126\/science.1135245","article-title":"A genome-wide association study identifies IL23R as an inflammatory bowel disease gene","volume":"314","author":"RH Duerr","year":"2006","journal-title":"Science"},{"issue":"5","key":"pone.0285918.ref057","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1002\/ibd.20126","article-title":"IL-23 receptor (IL-23R) gene protects against pediatric Crohn\u2019s disease.","volume":"13","author":"MC Dubinsky","year":"2007","journal-title":"Inflamm Bowel Dis."},{"issue":"16","key":"pone.0285918.ref058","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1056\/NEJMoa1203572","article-title":"Ustekinumab induction and maintenance therapy in refractory Crohn\u2019s disease","volume":"367","author":"WJ Sandborn","year":"2012","journal-title":"N Engl J Med"},{"issue":"10080","key":"pone.0285918.ref059","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1016\/S0140-6736(17)30570-6","article-title":"Induction therapy with the selective interleukin-23 inhibitor risankizumab in patients with moderate-to-severe Crohn\u2019s disease: a randomised, double-blind, placebo-controlled phase 2 study","volume":"389","author":"BG Feagan","year":"2017","journal-title":"Lancet"},{"issue":"1","key":"pone.0285918.ref060","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1053\/j.gastro.2017.03.049","article-title":"Efficacy and Safety of MEDI2070, an Antibody Against Interleukin 23, in Patients With Moderate to Severe Crohn\u2019s Disease: A Phase 2a Study.","volume":"153","author":"BE Sands","year":"2017","journal-title":"Gastroenterology"},{"issue":"6","key":"pone.0285918.ref061","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1007\/s40259-020-00451-w","article-title":"Clinical Trials of IL-12\/IL-23 Inhibitors in Inflammatory Bowel Disease.","volume":"34","author":"A Almradi","year":"2020","journal-title":"Biodrugs."},{"issue":"12","key":"pone.0285918.ref062","doi-asserted-by":"crossref","first-page":"e51819","DOI":"10.1371\/journal.pone.0051819","article-title":"Ustekinumab improves psoriasis without altering T cell cytokine production, differentiation, and T cell receptor repertoire diversity.","volume":"7","author":"K Tsuda","year":"2012","journal-title":"PLoS One."},{"issue":"1","key":"pone.0285918.ref063","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/bjd.15029","article-title":"Persistence of interleukin (IL)-17A+ T lymphocytes and IL-17A expression in treatment-resistant psoriatic plaques despite ustekinumab therapy.","volume":"177","author":"C Jack","year":"2017","journal-title":"Br J Dermatol"},{"issue":"9625","key":"pone.0285918.ref064","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1016\/S0140-6736(08)60725-4","article-title":"Efficacy and safety of ustekinumab, a human interleukin-12\/23 monoclonal antibody, in patients with psoriasis: 76-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 1).","volume":"371","author":"CL Leonardi","year":"2008","journal-title":"Lancet"},{"issue":"9625","key":"pone.0285918.ref065","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1016\/S0140-6736(08)60726-6","article-title":"Efficacy and safety of ustekinumab, a human interleukin-12\/23 monoclonal antibody, in patients with psoriasis: 52-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 2).","volume":"371","author":"KA Papp","year":"2008","journal-title":"Lancet"},{"issue":"1","key":"pone.0285918.ref066","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1002\/art.33314","article-title":"Mucosal-associated invariant T cells promote inflammation and exacerbate disease in murine models of arthritis","volume":"64","author":"A Chiba","year":"2012","journal-title":"Arthritis Rheum"},{"issue":"11","key":"pone.0285918.ref067","doi-asserted-by":"crossref","first-page":"2002","DOI":"10.1002\/eji.201747140","article-title":"IL-17 polarization of MAIT cells is derived from the activation of two different pathways","volume":"47","author":"G Guggino","year":"2017","journal-title":"Eur J Immunol"},{"issue":"41","key":"pone.0285918.ref068","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.aaw0402","article-title":"IL-23 costimulates antigen-specific MAIT cell activation and enables vaccination against bacterial infection","volume":"4","author":"H Wang","year":"2019","journal-title":"Sci Immunol"},{"issue":"1","key":"pone.0285918.ref069","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1097\/MIB.0000000000000242","article-title":"T-cell receptor sequencing reveals the clonal diversity and overlap of colonic effector and FOXP3+ T cells in ulcerative colitis.","volume":"21","author":"J Lord","year":"2015","journal-title":"Inflamm Bowel Dis."},{"key":"pone.0285918.ref070","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/978-1-4939-2963-4_15","article-title":"Single-Cell Analysis of T-Cell Receptor alphabeta Repertoire","volume":"1343","author":"P Dash","year":"2015","journal-title":"Methods Mol Biol"},{"issue":"18","key":"pone.0285918.ref071","doi-asserted-by":"crossref","first-page":"3240","DOI":"10.3748\/wjg.v23.i18.3240","article-title":"Thiopurine use associated with reduced B and natural killer cells in inflammatory bowel disease","volume":"23","author":"JD Lord","year":"2017","journal-title":"World J Gastroenterol"},{"issue":"11","key":"pone.0285918.ref072","doi-asserted-by":"crossref","first-page":"2305","DOI":"10.1084\/jem.20130958","article-title":"Antigen-loaded MR1 tetramers define T cell receptor heterogeneity in mucosal-associated invariant T cells","volume":"210","author":"R Reantragoon","year":"2013","journal-title":"J Exp Med"},{"key":"pone.0285918.ref073","doi-asserted-by":"crossref","first-page":"3866","DOI":"10.1038\/ncomms4866","article-title":"Parallel T-cell cloning and deep sequencing of human MAIT cells reveal stable oligoclonal TCRbeta repertoire.","volume":"5","author":"M Lepore","year":"2014","journal-title":"Nat Commun."},{"issue":"1","key":"pone.0285918.ref074","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.immuni.2017.11.025","article-title":"Innate-like Cytotoxic Function of Bystander-Activated CD8(+) T Cells Is Associated with Liver Injury in Acute Hepatitis A.","volume":"48","author":"J Kim","year":"2018","journal-title":"Immunity"},{"issue":"11","key":"pone.0285918.ref075","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.1136\/gutjnl-2016-311824","article-title":"Anti-NKG2D monoclonal antibody (NNC0142-0002) in active Crohn\u2019s disease: a randomised controlled trial.","volume":"66","author":"M Allez","year":"2017","journal-title":"Gut"},{"issue":"6502","key":"pone.0285918.ref076","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1038\/372190a0","article-title":"Adhesion between epithelial cells and T lymphocytes mediated by E-cadherin and the alpha E beta 7 integrin","volume":"372","author":"KL Cepek","year":"1994","journal-title":"Nature"},{"issue":"9","key":"pone.0285918.ref077","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1097\/MIB.0000000000001204","article-title":"CD103+ Dendritic Cell Function Is Altered in the Colons of Patients with Ulcerative Colitis.","volume":"23","author":"H Matsuno","year":"2017","journal-title":"Inflamm Bowel Dis"},{"issue":"9","key":"pone.0285918.ref078","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1093\/ibd\/izz049","article-title":"Intestinal CD103+CD4+ and CD103+CD8+ T-Cell Subsets in the Gut of Inflammatory Bowel Disease Patients at Diagnosis and During Follow-up.","volume":"25","author":"B Roosenboom","year":"2019","journal-title":"Inflamm Bowel Dis"},{"issue":"6663","key":"pone.0285918.ref079","doi-asserted-by":"crossref","first-page":"eadh0301","DOI":"10.1126\/science.adh0301","article-title":"Conserved gammadelta T cell selection by BTNL proteins limits progression of human inflammatory bowel disease","volume":"381","author":"RJ Dart","year":"2023","journal-title":"Science"},{"issue":"8","key":"pone.0285918.ref080","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1084\/jem.20140507","article-title":"MR1-restricted MAIT cells display ligand discrimination and pathogen selectivity through distinct T cell receptor usage","volume":"211","author":"MC Gold","year":"2014","journal-title":"J Exp Med"},{"issue":"6","key":"pone.0285918.ref081","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1053\/j.gastro.2006.02.009","article-title":"Candida albicans is an immunogen for anti-Saccharomyces cerevisiae antibody markers of Crohn\u2019s disease","volume":"130","author":"A Standaert-Vitse","year":"2006","journal-title":"Gastroenterology"},{"issue":"5","key":"pone.0285918.ref082","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1136\/gut.31.5.536","article-title":"Antibody to selected strains of Saccharomyces cerevisiae (baker\u2019s and brewer\u2019s yeast) and Candida albicans in Crohn\u2019s disease.","volume":"31","author":"H McKenzie","year":"1990","journal-title":"Gut"},{"issue":"8","key":"pone.0285918.ref083","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1136\/gut.2003.030734","article-title":"Anti-Saccharomyces cerevisiae antibody (ASCA) positivity is associated with increased risk for early surgery in Crohn\u2019s disease.","volume":"53","author":"DG Forcione","year":"2004","journal-title":"Gut"}],"container-title":["PLOS 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