{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T04:18:43Z","timestamp":1747196323284,"version":"3.40.5"},"reference-count":27,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2023,6,2]],"date-time":"2023-06-02T00:00:00Z","timestamp":1685664000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>Hypertensive disorders of pregnancy are reported as the second leading root of maternal morbidity and mortality in Zanzibar. Evidence shows that the majority of pregnant women in Zanzibar are referred late from lower-level healthcare facilities, and majority develop complications of eclampsia. This study\u2019s goal is to determine if all public healthcare facilities in Zanzibar are prepared to manage pre-eclampsia cases and if lower-levels public healthcare facilities are ready to refer pre-eclampsia cases. This will be a descriptive cross-sectional study that will involve a total of 54 healthcare facilities and 176 health care providers working in antenatal clinics. All public health care facilities will be stratified into tertiary, secondary, and primary strata. A simple random sampling will be used to select 46 healthcare facilities in the primary stratum while all healthcare facilities within the tertiary and secondary strata will be selected. In each healthcare facility, a physical observation will be performed to assess the availability of equipment and supplies, medications, and lab tests, while a self-administered questionnaire will be used to assess the knowledge level and skills of healthcare providers for the management of pre-eclampsia and eclampsia. Patient\u2019s case files in the tertiary and secondary strata will be reviewed to assess the quality of management of pre-eclampsia while the service records of the primary stratum will be assessed for compliance status with referral guidelines. Data will be analyzed using SPSS version 25. Descriptive statistics will be used to describe the frequency distribution of the study variables, and results will be presented in terms of frequency and percentage. The Chi-square test will be used to describe the relationship between variables, and a p-value of &lt; 0.05 will be regarded as a statistically significant difference.<\/jats:p>","DOI":"10.1371\/journal.pone.0286498","type":"journal-article","created":{"date-parts":[[2023,6,2]],"date-time":"2023-06-02T17:31:37Z","timestamp":1685727097000},"page":"e0286498","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Auditing the readiness of healthcare facilities for referral and management of pre-eclampsia cases in Zanzibar- a study protocol"],"prefix":"10.1371","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9763-3813","authenticated-orcid":true,"given":"Salma A.","family":"Rashid","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saada A.","family":"Seif","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2023,6,2]]},"reference":[{"issue":"1","key":"pone.0286498.ref001","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0029-7844(01)01747-1","article-title":"Practice bulletin #33: diagnosis and management of preeclampsia and eclampsia","volume":"99","author":"ACOG Committee on Obstetric Practice","year":"2002","journal-title":"Obstet. Gynecol."},{"key":"pone.0286498.ref002","first-page":"3183","author":"J. M. Roberts","year":"2014","journal-title":"Contemporary Concepts of the Pathogenesis and Management of Preeclampsia"},{"issue":"3","key":"pone.0286498.ref003","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0091198","article-title":"Risk factors of pre-eclampsia\/eclampsia and its adverse outcomes in low- and middle-income countries: A WHO secondary analysis","volume":"9","author":"V. L. Bilano","year":"2014","journal-title":"PLoS One"},{"issue":"10","key":"pone.0286498.ref004","first-page":"415","article-title":"Risk factors for severe pre-eclampsia and eclampsia in Mulago Hospital, Kampala, Uganda","volume":"87","author":"J. Wandabwa","year":"2010","journal-title":"East Afr. Med. J."},{"key":"pone.0286498.ref005","first-page":"1","article-title":"Delivery Hospitalizations Involving Preeclampsia and Eclampsia, 2005\u20132014: Statistical Brief #222","author":"K. R. Fingar","year":"2006","journal-title":"Healthc. Cost Util. Proj. Stat. Briefs"},{"journal-title":"Factors Contibuting To Adverse Outcomes Of Pre-Eclampsia Among Pregnant Women Attending Antenatal Clinics In Kibera Slums, Nairobi","year":"2012","author":"A. N. Otieno","key":"pone.0286498.ref006"},{"key":"pone.0286498.ref007","first-page":"1","author":"A. S. Belay","year":"2019","journal-title":"Prevalence and associated factors of pre- eclampsia among pregnant women attending anti-natal care at Mettu Karl referal hospital, Ethiopia: cross-sectional study"},{"issue":"2","key":"pone.0286498.ref008","doi-asserted-by":"crossref","first-page":"78","DOI":"10.5897\/JPHE2019.1143","article-title":"Prevalence and risk factors for pre-eclampsia\/eclampsia in Northern Tanzania","volume":"12","author":"I. O. Frank","year":"2020","journal-title":"J. Public Heal. 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