{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T08:35:36Z","timestamp":1789720536081,"version":"4.0.1"},"reference-count":40,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T00:00:00Z","timestamp":1692921600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>\n                    Anterior chamber depth (ACD) is a quantitative trait associated with primary angle closure glaucoma (PACG). Although ACD is highly heritable, known genetic variations explain a small fraction of the phenotypic variability. The purpose of this study was to identify additional ACD-influencing loci using strains of mice. Cohorts of 86 N2 and 111 F2 mice were generated from crosses between recombinant inbred BXD24\/TyJ and wild-derived CAST\/EiJ mice. Using anterior chamber optical coherence tomography, mice were phenotyped at 10\u201312 weeks of age, genotyped based on 93 genome-wide SNPs, and subjected to quantitative trait locus (QTL) analysis. In an analysis of ACD among all mice, six loci passed the significance threshold of\n                    <jats:italic>p<\/jats:italic>\n                    = 0.05 and persisted after multiple regression analysis. These were on chromosomes 6, 7, 11, 12, 15 and 17 (named\n                    <jats:italic>Acdq6<\/jats:italic>\n                    ,\n                    <jats:italic>Acdq7<\/jats:italic>\n                    ,\n                    <jats:italic>Acdq11<\/jats:italic>\n                    ,\n                    <jats:italic>Acdq12<\/jats:italic>\n                    ,\n                    <jats:italic>Acdq15<\/jats:italic>\n                    , and\n                    <jats:italic>Acdq17<\/jats:italic>\n                    , respectively). Our findings demonstrate a quantitative multi-genic pattern of ACD inheritance in mice and identify six previously unrecognized ACD-influencing loci. We have taken a unique approach to studying the anterior chamber depth phenotype by using mice as genetic tool to examine this continuously distributed trait.\n                  <\/jats:p>","DOI":"10.1371\/journal.pone.0286897","type":"journal-article","created":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T13:25:00Z","timestamp":1692969900000},"page":"e0286897","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":2,"title":["Anterior chamber depth in mice is controlled by several quantitative trait loci"],"prefix":"10.1371","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7286-3855","authenticated-orcid":true,"given":"Demelza R.","family":"Larson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allysa J.","family":"Kimber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kacie J.","family":"Meyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael G.","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2023,8,25]]},"reference":[{"issue":"11","key":"pone.0286897.ref001","doi-asserted-by":"crossref","first-page":"4790","DOI":"10.1167\/iovs.08-2130","article-title":"Shared genetic determinant of axial length, anterior chamber depth, and angle opening distance: the Guangzhou Twin Eye Study","volume":"49","author":"M He","year":"2008","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"1","key":"pone.0286897.ref002","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1167\/iovs.07-1052","article-title":"Heritability of anterior chamber depth as an intermediate phenotype of angle-closure in Chinese: the Guangzhou Twin Eye Study","volume":"49","author":"M He","year":"2008","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"5","key":"pone.0286897.ref003","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1001\/archophthalmol.2009.61","article-title":"Heritability analysis of spherical equivalent, axial length, corneal curvature, and anterior chamber depth in the Beaver Dam Eye Study","volume":"127","author":"AP Klein","year":"2009","journal-title":"Arch Ophthalmol"},{"issue":"12","key":"pone.0286897.ref004","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1136\/bjo.85.12.1470","article-title":"The importance of genes and environment for ocular refraction and its determiners: a population based study among 20\u201345 year old twins","volume":"85","author":"N Lyhne","year":"2001","journal-title":"Br J Ophthalmol"},{"issue":"3","key":"pone.0286897.ref005","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1136\/bjo.54.3.161","article-title":"Aetiology of the anatomical basis for primary angle-closure glaucoma. 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