{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T09:49:39Z","timestamp":1780480179740,"version":"3.54.1"},"reference-count":55,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2023,6,28]],"date-time":"2023-06-28T00:00:00Z","timestamp":1687910400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010414","name":"Health Research Board","doi-asserted-by":"publisher","award":["13F492"],"award-info":[{"award-number":["13F492"]}],"id":[{"id":"10.13039\/100010414","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>Research studies have observed associations of vitamin D with inflammation but data in representative older adult studies is lacking. We aimed to investigate the association of C-reactive protein (CRP) with vitamin D status in a representative sample of the older Irish population. The concentrations of 25-hydroxyvitamin D (25(OH)D) and CRP was measured in 5,381 community dwelling Irish adults aged \u226550 years from the Irish Longitudinal Study on Ageing (TILDA). Demographic, health and lifestyle variables were assessed by questionnaire and categorical proportions of CRP were generated by vitamin D status and age. Multi-nominal logistic regression was used to investigate the association of 25(OH)D and CRP status. The prevalence (mean; 95% confidence interval (95% CI)) of normal CRP status (0\u20135 mg\/dL) was 83.9% (82.6\u201385.0%), elevated status (5\u201310 mg\/dL) 11.0% (9.9\u201312.0%) and high status (&gt;10 mg\/dL) was 5.1% (4.5\u20135.8%). Mean (95% CI) CRP concentrations were lower in those with normal vs. deficient 25(OH)D status (2.02 mg\/dL (1.95\u20132.08) vs. 2.60 mg\/dL (2.41\u20132.82); p&lt;0.0001). In a logistic regression analysis, those with insufficient or sufficient 25(OH)D status were less likely to have a high CRP status compared to those with deficient 25(OH)D status (insufficient: coefficient (CE) -0.732, 95% CI -1.12\u20130.33, p&lt;0.0001; sufficient: CE -0.599, 95% CI -0.95\u20130.24, p = 0.001). In conclusion older adults with deficient vitamin D status had higher levels of inflammation as measured by CRP. Given that inflammation is an important pathological driver of chronic diseases of ageing, and that emerging evidence suggests that vitamin D therapy can reduce inflammation in some disease settings, optimising vitamin D status could represent an effective low risk\/low-cost pathway to modulate inflammation in community dwelling older adults.<\/jats:p>","DOI":"10.1371\/journal.pone.0287169","type":"journal-article","created":{"date-parts":[[2023,6,28]],"date-time":"2023-06-28T17:23:01Z","timestamp":1687972981000},"page":"e0287169","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":17,"title":["Vitamin D status &amp; associations with inflammation in older adults"],"prefix":"10.1371","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4225-5223","authenticated-orcid":true,"given":"Eamon","family":"Laird","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5498-4453","authenticated-orcid":true,"given":"Aisling M.","family":"O\u2019Halloran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne M.","family":"Molloy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Healy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nollaig","family":"Bourke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rose Anne","family":"Kenny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2023,6,28]]},"reference":[{"issue":"7","key":"pone.0287169.ref001","doi-asserted-by":"crossref","first-page":"693","DOI":"10.3390\/nu2070693","article-title":"Vitamin D and bone health; Potential mechanisms","volume":"2","author":"E Laird","year":"2010","journal-title":"Nutrients"},{"issue":"10","key":"pone.0287169.ref002","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1016\/j.autrev.2013.02.004","article-title":"Vitamin D effects on musculoskeletal health, immunity, autoimmunity, cardiovascular disease, cancer, fertility, pregnancy, dementia and mortality-a review of recent evidence","volume":"12","author":"P Pludowski","year":"2013","journal-title":"Autoimmun Rev"},{"issue":"4","key":"pone.0287169.ref003","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1210\/er.2018-00126","article-title":"Skeletal and extraskeletal actions of vitamin D: current evidence and outstanding questions","volume":"40","author":"R Bouillon","year":"2019","journal-title":"Endocr Rev"},{"issue":"4","key":"pone.0287169.ref004","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.amjmed.2009.09.024","article-title":"Does vitamin D modulate asymmetric dimethylarginine and C-reactive protein concentrations","volume":"123","author":"DT Ngo","year":"2010","journal-title":"Am J Med"},{"key":"pone.0287169.ref005","unstructured":"Scientific Advisory Committee on Nutrition. Vitamin D and health. 2016."},{"key":"pone.0287169.ref006","unstructured":"Vitamin D Scientific Recommendations for Food-Based Dietary Guidelines For Older Adults In Ireland 2020. Food Safety Authority of Ireland accessed 17\/11\/22 https:\/\/www.fsai.ie\/news#:~:text=A%20daily%2015%20%C2%B5g%20vitamin,this%20vitamin%20from%20sunlight%20exposure."},{"issue":"4","key":"pone.0287169.ref007","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1093\/gerona\/glx168","article-title":"The prevalence of vitamin D deficiency and the determinants of 25 (OH) D concentration in older Irish adults: Data from The Irish Longitudinal Study on Ageing (TILDA).","volume":"73","author":"E Laird","year":"2018","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"pone.0287169.ref008","article-title":"Vitamin D deficiency in Ireland: Implications for COVID-19","author":"E Laird","year":"2020","journal-title":"Results from the Irish Longitudinal Study on Ageing"},{"issue":"2","key":"pone.0287169.ref009","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1111\/j.1365-2567.2011.03482.x","article-title":"Vitamin D3: a helpful immuno-modulator","volume":"134","author":"M 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